2. Gene
  3. MRPL18 - mitochondrial ribosomal protein L18 Gene

MRPL18 - mitochondrial ribosomal protein L18 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as L18mt; HSPC071; MRP-L18

Gene ID: 29074 | Gene type: protein coding

About MRPL18

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:159,789,812-159,798,429 (from NCBI)

This gene has 4 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 18.5), colon (RPKM 17.9) and 25 other tissues.

Summary

This nuclear gene encodes a protein component of the larger 39S subunit of mitochondrial ribosome. This protein may also aid in the import of nuclear-encoded 5S rRNA into mitochondria. Alternative splicing results in multiple transcript variants, most of which are not predicted to encode a protein. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Jan 2016]

MRPL18 Products(2)

mRNA Protein Name
NM_001318817.2 NP_001305746.1 39S ribosomal protein L18, mitochondrial isoform 2
NM_014161.5 NP_054880.2 39S ribosomal protein L18, mitochondrial isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 5S rRNA binding IDA
IDA: Inferred from direct assay
21685364 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Reference Source
involved in rRNA import into mitochondrion IDA
IDA: Inferred from direct assay
21685364 GOA
Cellular Component GO Annotation Evidence Reference Source
part of mitochondrial large ribosomal subunit IDA
IDA: Inferred from direct assay
25278503 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
28892042 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPL18 Protein Structure

Ribosomal_L18p

Ribosomal_L18p: Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast (79 - 146)

  • 0
  • 100
  • 180 a.a.
Protein Preferred Names Protein Names

39S ribosomal protein L18, mitochondrial

mitochondrial large ribosomal subunit protein uL18m

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08665 MRPL18 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MRPL18 VGNC VGNC:31621
Mus musculus MRPL18 MGD MGI:1914931
Canis familiaris MRPL18 VGNC VGNC:43382
Felis catus MRPL18 VGNC VGNC:63596
Rattus norvegicus MRPL18 RGD RGD:1306387