LAPTM5 - lysosomal protein transmembrane 5 Gene

Homo sapiens

Also known as CLAST6

Gene ID: 7805 | Gene type: protein coding

About LAPTM5

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:30,732,469-30,757,774 (from NCBI)

This gene has 3 transcripts (splice variants), 115 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 488.0), lymph node (RPKM 349.3) and 15 other tissues.

Summary

This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]

LAPTM5 Products(1)

mRNA	Protein	Name
NM_006762.3	NP_006753.1	lysosomal-associated transmembrane protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17116753	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	17116753	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	28464033	GOA
involved in defense response to tumor cell	IDA IDA: Inferred from direct assay	19787053	GOA
involved in induction of programmed cell death	IDA IDA: Inferred from direct assay	19787053	GOA
involved in negative regulation of autophagic cell death	IDA IDA: Inferred from direct assay	19787053	GOA
involved in positive regulation of lysosomal membrane permeability	IDA IDA: Inferred from direct assay	19787053	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	22009753	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	17116753	GOA
located in lysosome	IDA IDA: Inferred from direct assay	8661146	GOA
located in perinuclear region of cytoplasm	IMP IMP: Inferred from mutant phenotype	28464033	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8661146	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	17116753	GOA
located in transport vesicle	IDA IDA: Inferred from direct assay	19787053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAPTM5 Protein Structure

Mtp

0
100
200
262 a.a.

Protein Preferred Names

Protein Names

lysosomal-associated transmembrane protein 5

CD40-ligand-activated specific transcripts

LAPTM5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LAPTM5	Q13571	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	25416956
Intra	LAPTM5	Q13571	DISP1	Homo sapiens	Q96F81	Y2H Prey Pooling	25416956
Intra	LAPTM5	Q13571	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
Intra	LAPTM5	Q13571	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	LAPTM5	Q13571	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	LAPTM5	Q13571	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	LAPTM5	Q13571	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	LAPTM5	Q13571	KIR3DL3	Homo sapiens	Q8N743	Validated Y2H	32296183
Intra	LAPTM5	Q13571	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
Intra	LAPTM5	Q13571	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
Intra	LAPTM5	Q13571	MRPL18	Homo sapiens	Q9H0U6	Validated Y2H	32296183
Intra	LAPTM5	Q13571	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	LAPTM5	Q13571	UBE2J1	Homo sapiens	Q9Y385	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pigmented Villonodular Synovitis

Diffuse Giant Cell Tumor Of Tenosynovium	Villous Tenosynovitis
Diffuse Pigmented Villonodular Synovitis	Diffuse-Type Gct
Diffuse-Type Giant Cell Tumor	Localized Pigmented Villonodular Synovitis
Tgct	Tsgct
Tenosynovial Giant Cell Tumor	Tenosynovial Giant Cell Tumors
Synovitis Pigmented Villonodular	Synovitis, Pigmented Villonodular
Fibrous Histiocytoma Of Tendon Sheath	Testicular Germ Cell Tumor
Chronic Haemorrhagic Villous Synovitis	Pvns - [Pigmented Villonodular Synovitis]
Villonodular Synovitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07523	LAPTM5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LAPTM5	RGD	RGD:621838
Bos taurus	LAPTM5	VGNC	VGNC:30788
Canis familiaris	LAPTM5	VGNC	VGNC:42584
Macaca mulatta	LAPTM5	VGNC	VGNC:74162
Felis catus	LAPTM5	VGNC	VGNC:63190
Mus musculus	LAPTM5	MGD	MGI:108046

Name
Email *

	Sorry, but the email address you supplied was invalid.