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  3. UBE2T - ubiquitin conjugating enzyme E2 T Gene

UBE2T - ubiquitin conjugating enzyme E2 T Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FANCT; PIG50; HSPC150

Gene ID: 29089 | Gene type: protein coding

About UBE2T

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,331,657-202,341,936 (from NCBI)

This gene has 12 transcripts (splice variants), 196 orthologues, 24 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 10.4), bone marrow (RPKM 10.2) and 22 other tissues.

Summary

The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

UBE2T Products(2)

mRNA Protein Name
NM_001310326.2 NP_001297255.1 ubiquitin-conjugating enzyme E2 T isoform 2
NM_014176.4 NP_054895.1 ubiquitin-conjugating enzyme E2 T isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
17938197 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24389026 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: Inferred from direct assay
19589784 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
16916645 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
16916645 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
16916645 GOA
involved in DNA repair IMP
IMP: Inferred from mutant phenotype
16916645 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K27-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K29-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K6-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
16916645 GOA
involved in protein monoubiquitination IDA
IDA: Inferred from direct assay
16916645 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2T Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (6 - 146)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 T

E2 ubiquitin-conjugating enzyme T

UBE2T Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UBE2T Q9NPD8 FANCL Homo sapiens Q9NW38-1
Comig Non-Denat Gel
24389026
Intra
UBE2T Q9NPD8 FANCL Homo sapiens Q9NW38-1
GMS
24389026
Intra
UBE2T Q9NPD8 GNB2 Homo sapiens P62879
Validated Y2H
32814053
Intra
UBE2T Q9NPD8 GNB2 Homo sapiens P62879
Y2H Array
32814053
Intra
UBE2T Q9NPD8 GNB2 Homo sapiens P62879
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2T Proteins

Cat. No. Product Name Accession Purity
HY-P71409 UBE2T Protein, Human (His) Q9NPD8 (M1-V197) ≥95%

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group T

Fanconi Anemia Complementation Group T

FANCT
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Fanconi Anemia, Complementation Group R

Fanconi Anemia Complementation Group R

FANCR
Fanconi Anemia, Complementation Group Q

Fanconi Anemia Complementation Group Q

FANCQ
Fanconi Anemia, Complementation Group I

Fanconi Anemia Complementation Group I

FANCI
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Fanconi Anemia, Complementation Group D2

Fanconi Anemia Complementation Group D2

FANCD2

Fad2

Fa4

Fancd

Fanconi Pancytopenia Type 4

Fanconi Anemia, Complementation Group D

Fanconi Pancytopenia, Type 4

Facd

Fanconi Anemia Complementation Group D
Aplastic Anemia

Aplastic Anemia, Susceptibility To

Anemia Aplastic

Idiopathic Aplastic Anemia

Secondary Aplastic Anemia

Idiopathic Bone Marrow Failure

Aplastic Anemia Idiopathic

AA

Anemia, Aplastic

Aplastic Anemia, Idiopathic

Erythroid Aplasia

Aa - [Aplastic Anaemia]

Haematopoietic Aplasia

Aleukia Haemorrhagica

Anaemia Due To Decreased Red Cell Production

Aplasia Bone Marrow

Aplastic Bone Marrow

Hypoplastic Anaemia Nos

Myeloid Bone Marrow Aplasia

Pancytopenia

Panhaematopenia

Hypoproliferative Anaemia

Medullary Hypoplasia

Red Blood Cells Hypoplastic Anaemia

Panmyelophthisis

Panhemocytopenia

Refractive Hypoproliferative Anaemia

Toxic Anaemia

Toxic Aplastic Anaemia

Aplastic Anaemia Due To Toxic Cause

Idiopathic Aplastic Anaemia Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141891 M435-1279 Inhibitor 98.43% Unkown
HY-126539 UBE2T/FANCL-IN-1 99.83% Unkown
HY-RS15362 UBE2T Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UBE2T VGNC VGNC:36596
Macaca mulatta UBE2T VGNC VGNC:79467
Felis catus UBE2T VGNC VGNC:66765
Mus musculus UBE2T MGD MGI:1914446
Canis familiaris UBE2T VGNC VGNC:48066
Rattus norvegicus UBE2T RGD RGD:1310816
Others UBE2T NCBI