FHOD1 - formin homology 2 domain containing 1 Gene

Homo sapiens

Also known as FHOS

Gene ID: 29109 | Gene type: protein coding

About FHOD1

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,229,389-67,247,481 (from NCBI)

This gene has 10 transcripts (splice variants), 223 orthologues and 18 paralogues. Broad expression in spleen (RPKM 38.0), lung (RPKM 13.5) and 20 other tissues.

Summary

This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

FHOD1 Products(2)

mRNA	Protein	Name
NM_001318202.2	NP_001305131.1	FH1/FH2 domain-containing protein 1 isoform 1
NM_013241.3	NP_037373.2	FH1/FH2 domain-containing protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18239683	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15095401	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	15095401	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15095401	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16361249	GOA
involved in regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	16361249	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15095401	GOA
colocalizes with stress fiber	IDA IDA: Inferred from direct assay	15095401	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FHOD1 Protein Structure

FH2

0
200
400
600
800
1000
1164 a.a.

Protein Preferred Names

Protein Names

FH1/FH2 domain-containing protein 1

formin homolog overexpressed in spleen 1

FHOD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	FHOD1	Q9Y613	Syne2	Mus musculus	Q6ZWQ0-1	Anti Tag CoIP	24880667
Cross	FHOD1	Q9Y613	Syne2	Mus musculus	Q6ZWQ0-1	Y2H	24880667
Intra	FHOD1	Q9Y613	SYNE2	Homo sapiens	Q8WXH0	Anti Bait CoIP	24880667
Intra	FHOD1	Q9Y613	SYNE2	Homo sapiens	Q8WXH0	Pull Down	24880667
Intra	FHOD1	Q9Y613	SYNE2	Homo sapiens	Q8WXH0	Y2H	24880667
Intra	FHOD1	Q9Y613	FHOD1	Homo sapiens	Q9Y613	Pull Down	18239683
Intra	FHOD1	Q9Y613	TRIM21	Homo sapiens	P19474	Y2H Prey Pooling	32296183
Intra	FHOD1	Q9Y613	FHOD1	Homo sapiens	Q9Y613	Anti Tag CoIP	15642356
Intra	FHOD1	Q9Y613	TRIM21	Homo sapiens	P19474	Y2H Array	32296183
Intra	FHOD1	Q9Y613	FHOD1	Homo sapiens	Q9Y613	GMS	18786395
Intra	FHOD1	Q9Y613	FHOD1	Homo sapiens	Q9Y613	Y2H	15642356

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cerebral Amyloid Angiopathy, Itm2b-Related, 2

Dementia, Familial Danish	Fdd
Familial Danish Dementia	Heredopathia Ophthalmootoencephalica
Hooe	Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis
Adan Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy 2
Itm2b Amyloidosis	Familial Cerebral Amyloid Angiopathy
Itm2b-Related Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy
Familial Dementia, Danish Type	Cerebral Amyloid Angiopathy, Itm2b-Related 2
CAA-ITM2B2	Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis
Dementia, Familial, Danish

Mandibular Cancer

Mandibular Neoplasms	Malignant Neoplasm Of Inferior Maxilla
Malignant Neoplasm Of Lower Jaw Bone	Malignant Neoplasm Of Mandible
Mandible Cancer	Mandibular Neoplasm
Neoplasm Of Mandible

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04938	FHOD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FHOD1	VGNC	VGNC:72523
Felis catus	FHOD1	VGNC	VGNC:82340
Rattus norvegicus	FHOD1	RGD	RGD:1589776
Bos taurus	FHOD1	VGNC	VGNC:29003
Mus musculus	FHOD1	MGD	MGI:2679008
Canis familiaris	FHOD1	VGNC	VGNC:40875

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