BRD7 - bromodomain containing 7 Gene

Homo sapiens

Also known as BP75; NAG4; CELTIX1; SMARCI1

Gene ID: 29117 | Gene type: protein coding

About BRD7

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,315,957-50,368,988 (from NCBI)

This gene has 7 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 21.8), spleen (RPKM 16.7) and 25 other tissues.

Summary

This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

BRD7 Products(12)

mRNA	Protein	Name
NM_013263.5	NP_037395.2	bromodomain-containing protein 7 isoform 2
XM_017023180.2	XP_016878669.1	bromodomain-containing protein 7 isoform X6
NM_001173984.3	NP_001167455.1	bromodomain-containing protein 7 isoform 1
XM_011523046.4	XP_011521348.1	bromodomain-containing protein 7 isoform X1
XM_011523048.3	XP_011521350.1	bromodomain-containing protein 7 isoform X3
XM_047434006.1	XP_047289962.1	bromodomain-containing protein 7 isoform X7
XM_011523047.3	XP_011521349.1	bromodomain-containing protein 7 isoform X2
XM_047434007.1	XP_047289963.1	bromodomain-containing protein 7 isoform X8
XM_011523050.4	XP_011521352.1	bromodomain-containing protein 7 isoform X10
XM_047434008.1	XP_047289964.1	bromodomain-containing protein 7 isoform X9
XM_017023179.2	XP_016878668.1	bromodomain-containing protein 7 isoform X5
XM_011523049.3	XP_011521351.1	bromodomain-containing protein 7 isoform X4

BRD7 Protein Structure

Bromodomain

DUF3512

0
100
200
300
400
500
600
651 a.a.

Protein Preferred Names

Protein Names

bromodomain-containing protein 7

75 kDa bromodomain protein

protein CELTIX-1

Related Diseases

Diseases

Alias

Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium	Adenosquamous Carcinoma Of The Endometrium
Endometrial Adenosquamous Cancer	Endometrial Adenosquamous Cell Carcinoma

Neurilemmomatosis

Schwannomatosis	Neurofibromatosis Type 3
Nf3	Neurilemmomatosis Congenital Cutaneous
Neurinomatosis	Congenital Cutaneous Neurilemmomatosis
Multiple Neurilemmomas	Multiple Schwannomas
Neurilemmomatosis, Congenital Cutaneous	Schwannomatosis 1
Neurofibromatosis 3	Mixed Central And Peripheral Neurofibromatosis
Nf3 - [Neurofibromatosis Type 3]

Granular Cell Carcinoma

Granular Cell Cancer

Granular Cell Adenocarcinoma

Malignant Granular Cell Myoblastoma

Malignant Granular Cell Tumor	Granular Cell Tumor, Malignant
Malignant Granular Cell Neoplasm

Rhabdoid Cancer

Rhabdoid Tumor	Malignant Rhabdoid Tumor
Malignant Rhabdoid Tumour	Rhabdoid Sarcoma
Rhabdoid Tumor Predisposition Syndrome 1	Rhabdoid Tumor Predisposition Syndrome 2
Atypical Teratoid Rhabdoid Tumor	Brain Tumor, Posterior Fossa, Of Infancy, Familial
Atypical Teratoid/Rhabdoid Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114322	VZ185	Inhibitor	98.00%	Unkown
HY-100352	BI-9564	Inhibitor	98.73%	Unkown
HY-110374	NVS-CECR2-1	Inhibitor	99.40%	Unkown
HY-100517	TP-472	Inhibitor	99.52%	Unkown
HY-101121	NI-42	Inhibitor	99.53%	Unkown
HY-149806	Bromodomain IN-2	Inhibitor	/	Unkown
HY-116227	(2S,3R)-LP99	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BRD7	RGD	RGD:1309891
Felis catus	BRD7	VGNC	VGNC:60169
Bos taurus	BRD7	VGNC	VGNC:26560
Mus musculus	BRD7	MGD	MGI:1349766
Canis familiaris	BRD7	VGNC	VGNC:38521
Macaca mulatta	BRD7	VGNC	VGNC:103794

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