2. Gene
  3. BRD7 - bromodomain containing 7 Gene

BRD7 - bromodomain containing 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BP75; NAG4; CELTIX1; SMARCI1

Gene ID: 29117 | Gene type: protein coding

About BRD7

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,315,957-50,368,988 (from NCBI)

This gene has 7 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 21.8), spleen (RPKM 16.7) and 25 other tissues.

Summary

This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

BRD7 Products(12)

mRNA Protein Name
NM_013263.5 NP_037395.2 bromodomain-containing protein 7 isoform 2
XM_017023180.2 XP_016878669.1 bromodomain-containing protein 7 isoform X6
NM_001173984.3 NP_001167455.1 bromodomain-containing protein 7 isoform 1
XM_011523046.4 XP_011521348.1 bromodomain-containing protein 7 isoform X1
XM_011523048.3 XP_011521350.1 bromodomain-containing protein 7 isoform X3
XM_047434006.1 XP_047289962.1 bromodomain-containing protein 7 isoform X7
XM_011523047.3 XP_011521349.1 bromodomain-containing protein 7 isoform X2
XM_047434007.1 XP_047289963.1 bromodomain-containing protein 7 isoform X8
XM_011523050.4 XP_011521352.1 bromodomain-containing protein 7 isoform X10
XM_047434008.1 XP_047289964.1 bromodomain-containing protein 7 isoform X9
XM_017023179.2 XP_016878668.1 bromodomain-containing protein 7 isoform X5
XM_011523049.3 XP_011521351.1 bromodomain-containing protein 7 isoform X4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables histone binding IDA
IDA: Inferred from direct assay
12489984 GOA
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
16265664 GOA
enables p53 binding IPI
IPI: Inferred from physical interaction
20228809 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12489984 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
20228809 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
20228809 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
16265664 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16265664 GOA
involved in negative regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
16265664 GOA
involved in regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
20228809 GOA
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12489984 GOA
involved in transcription initiation-coupled chromatin remodeling IMP
IMP: Inferred from mutant phenotype
20228809 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
11025449 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRD7 Protein Structure

Bromodomain

Bromodomain: Bromodomain (141 - 223)

DUF3512

DUF3512: Domain of unknown function (DUF3512) (287 - 534)

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  • 651 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 7

75 kDa bromodomain protein

protein CELTIX-1

BRD7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BRD7 Q9NPI1 TP53 Homo sapiens P04637
Anti Bait CoIP
20228809
Intra
BRD7 Q9NPI1 TP53 Homo sapiens P04637
Y2H
20228809
Intra
BRD7 Q9NPI1 TP53 Homo sapiens P04637
Pull Down
20228809
Intra
BRD7 Q9NPI1 EP300 Homo sapiens Q09472
Pull Down
20228809
Intra
BRD7 Q9NPI1 EP300 Homo sapiens Q09472
Anti Bait CoIP
20228809
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium

Adenosquamous Carcinoma Of The Endometrium

Endometrial Adenosquamous Cancer

Endometrial Adenosquamous Cell Carcinoma
Neurilemmomatosis

Schwannomatosis

Neurofibromatosis Type 3

Nf3

Neurilemmomatosis Congenital Cutaneous

Neurinomatosis

Congenital Cutaneous Neurilemmomatosis

Multiple Neurilemmomas

Multiple Schwannomas

Neurilemmomatosis, Congenital Cutaneous

Schwannomatosis 1

Neurofibromatosis 3

Mixed Central And Peripheral Neurofibromatosis

Nf3 - [Neurofibromatosis Type 3]
Granular Cell Carcinoma

Granular Cell Cancer

Granular Cell Adenocarcinoma
Malignant Granular Cell Myoblastoma

Malignant Granular Cell Tumor

Granular Cell Tumor, Malignant

Malignant Granular Cell Neoplasm
Rhabdoid Cancer

Rhabdoid Tumor

Malignant Rhabdoid Tumor

Malignant Rhabdoid Tumour

Rhabdoid Sarcoma

Rhabdoid Tumor Predisposition Syndrome 1

Rhabdoid Tumor Predisposition Syndrome 2

Atypical Teratoid Rhabdoid Tumor

Brain Tumor, Posterior Fossa, Of Infancy, Familial

Atypical Teratoid/Rhabdoid Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114322 VZ185 Inhibitor 98.00% Unkown
HY-100352 BI-9564 Inhibitor 98.73% Unkown
HY-110374 NVS-CECR2-1 Inhibitor 99.40% Unkown
HY-100517 TP-472 Inhibitor 99.52% Unkown
HY-101121 NI-42 Inhibitor 99.53% Unkown
HY-149806 Bromodomain IN-2 Inhibitor / Unkown
HY-116227 (2S,3R)-LP99 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BRD7 RGD RGD:1309891
Felis catus BRD7 VGNC VGNC:60169
Bos taurus BRD7 VGNC VGNC:26560
Mus musculus BRD7 MGD MGI:1349766
Canis familiaris BRD7 VGNC VGNC:38521
Macaca mulatta BRD7 VGNC VGNC:103794