Jag1 - jagged canonical Notch ligand 1 Gene

Rattus norvegicus

Gene ID: 29146 | Gene type: protein coding

About Jag1

Summary

Enables Notch binding activity and receptor ligand activity. Involved in several processes, including animal organ regeneration; inner ear auditory receptor cell differentiation; and positive regulation of cardiac epithelial to mesenchymal transition. Located in plasma membrane. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Jag1 Products(1)

mRNA	Protein	Name
NM_019147.2	NP_062020.2	protein jagged-1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables Notch binding	IPI IPI: Inferred from physical interaction	28089369	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20145246	RGD
enables receptor ligand activity	IDA IDA: Inferred from direct assay	7697721	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Notch signaling pathway	IDA IDA: Inferred from direct assay	7697721	RGD
involved in Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	15057910	RGD
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	15057910	RGD
involved in inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	10887092	RGD
involved in negative regulation of cell differentiation	IDA IDA: Inferred from direct assay	7697721	RGD
involved in positive regulation of cardiac epithelial to mesenchymal transition	IGI IGI: Inferred from genetic interaction	20951801	RGD
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	20951801	RGD
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15057910	RGD
involved in wound healing	IEP IEP: Inferred from expression pattern	11549580	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein jagged-1

jagged 1

Jag1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Jag1	Q63722	LRP1	Homo sapiens	Q07954	Anti Tag CoIP	20472562
Cross	Jag1	Q63722	Thbs2	Mus musculus	Q03350	Anti Tag CoIP	20472562

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1846A	Jagged-1 (188-204) (TFA)	Agonist	99.89%	Unkown
HY-P1846	Jagged-1 (188-204)	Agonist	/	Unkown
HY-RS07012	JAG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Jag1	NCBI	NCBI:182
Mus musculus	Jag1	NCBI	NCBI:16449

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