Nod2 - nucleotide-binding oligomerization domain containing 2 Gene

Rattus norvegicus

Also known as Card15

Gene ID: 291912 | Gene type: protein coding

About Nod2

Primary_assembly 19: 18,382,439-18,417,177 reverse strand.mRatBN7.2:CM026992.1

This gene has 2 transcripts (splice variants), 167 orthologues, 21 paralogues and is associated with 62 phenotypes. Biased expression in Spleen (RPKM 4.7), Adrenal (RPKM 4.1) and 7 other tissues.

Summary

Enables muramyl dipeptide binding activity. Involved in several processes, including cellular response to peptidoglycan; positive regulation of dendritic cell cytokine production; and response to muramyl dipeptide. Located in cytoplasm. Biomarker of colitis; middle cerebral artery infarction; and pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Nod2 Products(1)

mRNA	Protein	Name
NM_001106172.2	NP_001099642.1	nucleotide-binding oligomerization domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables muramyl dipeptide binding	IDA IDA: Inferred from direct assay	16973131	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20863826	RGD
involved in cellular response to peptidoglycan	IEP IEP: Inferred from expression pattern	24169446	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16254493	RGD
involved in positive regulation of dendritic cell cytokine production	IDA IDA: Inferred from direct assay	16818757	RGD
involved in response to muramyl dipeptide	IDA IDA: Inferred from direct assay	16973131	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	21057821	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nod2 Protein Structure

NACHT

NOD2_WH

NLRC4_HD2

PPP1R42

LRR_RI

0
200
400
600
800
1012 a.a.

Protein Preferred Names

Protein Names

nucleotide-binding oligomerization domain-containing protein 2

caspase recruitment domain family, member 15

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-13682	Mifamurtide	≥99.0%	Unkown
HY-13682B	Mifamurtide sodium	98.19%	Unkown
HY-13682C	Mifamurtide TFA	≥98.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100691	NOD-IN-1	Inhibitor	99.56%	Unkown
HY-147506	NOD2 antagonist 1	Antagonist	99.57%	Unkown
HY-168159	TLR7 agonist 27	Agonist	/	Unkown
HY-168010	RC529-MDP	Activator	/	Unkown
HY-146034	NOD1/2 antagonist-1	Antagonist	/	Unkown
HY-163274	NOD1 antagonist-1	Antagonist	/	Unkown
HY-168024	NOD1/2-IN-1	Inhibitor	/	Unkown
HY-168158	NOD2 agonist 3	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nod2	NCBI	NCBI:64127

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