S1pr2 - sphingosine-1-phosphate receptor 2 Gene

Rattus norvegicus

Also known as Edg5; H218; GPCR18; Gpcr13; snGPCR18

Gene ID: 29415 | Gene type: protein coding

About S1pr2

Primary_assembly 8: 19,502,627-19,523,574 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 192 orthologues, 18 paralogues and is associated with 6 phenotypes. Biased expression in Lung (RPKM 99.8), Heart (RPKM 92.4) and 9 other tissues.

Summary

Enables G protein-coupled peptide receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway; negative regulation of smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

S1pr2 Products(1)

mRNA	Protein	Name
NM_017192.2	NP_058888.1	sphingosine 1-phosphate receptor 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled peptide receptor activity	IDA IDA: Inferred from direct assay	29453251	RGD
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	9409733	RGD

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	29453251	RGD
acts upstream of or within negative regulation of smooth muscle cell migration	IGI IGI: Inferred from genetic interaction	29453251	RGD
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	29453251	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr2 Protein Structure

7tmA_S1PR2_Edg5

0
100
200
300
352 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 2

AGR16	G-protein coupled receptor 13
G-protein coupled receptor H218	S1P receptor 2
S1P receptor Edg-5	S1P2
endothelial differentiation G-protein coupled receptor 5	endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
sphingosine 1-phosphate receptor Edg-5

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	99.95%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139310	GLPG2938	Antagonist	99.93%	Unkown
HY-111253	CYM-5478	Agonist	99.90%	Unkown
HY-113934	L-threo Lysosphingomyelin (d18:1)	Agonist	≥98.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S1pr2	NCBI	NCBI:9294

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