Erbb3 - erb-b2 receptor tyrosine kinase 3 Gene

Rattus norvegicus

Also known as nuc-ErbB3

Gene ID: 29496 | Gene type: protein coding

About Erbb3

Primary_assembly 7: 996,225-1,015,525 reverse strand.mRatBN7.2:CM026980.1

This gene has 5 transcripts (splice variants), 280 orthologues, 54 paralogues and is associated with 44 phenotypes. Biased expression in Kidney (RPKM 239.), Liver (RPKM 25.8) and 7 other tissues.

Summary

Enables neuregulin binding activity and neuregulin receptor activity. Involved in several processes, including animal organ development; cellular response to Insulin stimulus; and positive regulation of glucose import. Located in nucleus and postsynaptic membrane. Biomarker of chronic obstructive pulmonary disease and median neuropathy. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Erbb3 Products(1)

mRNA	Protein	Name
NM_017218.3	NP_058914.2	receptor tyrosine-protein kinase erbB-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neuregulin binding	IMP IMP: Inferred from mutant phenotype	14711829	RGD
enables neuregulin receptor activity	IMP IMP: Inferred from mutant phenotype	14711829	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonogenesis	IEP IEP: Inferred from expression pattern	9030624	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	9389501	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	30813222	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	12454858	RGD
involved in epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14711829	RGD
involved in mammary gland involution	IEP IEP: Inferred from expression pattern	10653587	RGD
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	14711829	RGD
involved in positive regulation of membrane permeability	IMP IMP: Inferred from mutant phenotype	30813222	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18184445	RGD
involved in skeletal muscle tissue development	IEP IEP: Inferred from expression pattern	8846777	RGD
involved in tongue development	IEP IEP: Inferred from expression pattern	10908606	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuronal cell body	IDA IDA: Inferred from direct assay	16859650	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	7589796	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Erbb3 Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

GF_recep_IV

TM_ErbB3

PKc_like

0
300
600
900
1200
1339 a.a.

Protein Preferred Names

Protein Names

receptor tyrosine-protein kinase erbB-3

avian erythroblastosis oncogene B 3	c-erbB-3
c-erbB3	proto-oncogene-like protein c-ErbB-3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

Recombinant Erbb3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74892	HER3 Protein, Rat (HEK293, Fc)	G3V6N1 (S20-H641)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-118998	TX2-121-1	Inhibitor	/	Phase 3
HY-13050	Sapitinib	Inhibitor	99.93%	Phase 2

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99275	Patritumab	Inhibitor	98.95%	Phase 3
HY-P99268	Seribantumab		≥95.0%	Phase 2
HY-P99866	Duligotuzumab		97.93%	Phase 2
HY-P99672	Istiratumab	Inhibitor	/	Phase 2
HY-P99304	Lumretuzumab	Inhibitor	≥99.0%	Phase 1
HY-P99461	Barecetamab	Inhibitor	97.96%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100848	TX1-85-1	Inhibitor	98.04%	Unkown
HY-18609	PD158780	Inhibitor	99.56%	Unkown
HY-W006886	Fmoc-(R)-2-(7-octenyl)Ala-OH		98.85%	Unkown
HY-13050A	Sapitinib fumarate	Inhibitor	/	Unkown
HY-RS04469	ERBB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04470	Erbb3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04471	Erbb3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-164548	WK88-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Erbb3	NCBI	NCBI:2065
Mus musculus	Erbb3	NCBI	NCBI:13867
Macaca mulatta	Erbb3	NCBI	NCBI:711407

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