1. Gene
  2. Erbb3 - erb-b2 receptor tyrosine kinase 3 Gene

Erbb3 - erb-b2 receptor tyrosine kinase 3 Gene

Rattus norvegicus

Also known as nuc-ErbB3

Gene ID: 29496 | Gene type: protein coding

About Erbb3

Primary_assembly 7: 996,225-1,015,525 reverse strand.mRatBN7.2:CM026980.1

This gene has 5 transcripts (splice variants), 280 orthologues, 54 paralogues and is associated with 44 phenotypes. Biased expression in Kidney (RPKM 239.), Liver (RPKM 25.8) and 7 other tissues.

Summary

Enables neuregulin binding activity and neuregulin receptor activity. Involved in several processes, including animal organ development; cellular response to Insulin stimulus; and positive regulation of glucose import. Located in nucleus and postsynaptic membrane. Biomarker of chronic obstructive pulmonary disease and median neuropathy. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Erbb3 Products(1)

mRNA Protein Name
NM_017218.3 NP_058914.2 receptor tyrosine-protein kinase erbB-3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables neuregulin binding IMP
IMP: Inferred from mutant phenotype
14711829 RGD
enables neuregulin receptor activity IMP
IMP: Inferred from mutant phenotype
14711829 RGD
Biological Process GO Annotation Evidence Reference Source
involved in axonogenesis IEP
IEP: Inferred from expression pattern
9030624 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
9389501 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
30813222 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
12454858 RGD
involved in epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14711829 RGD
involved in mammary gland involution IEP
IEP: Inferred from expression pattern
10653587 RGD
involved in positive regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
14711829 RGD
involved in positive regulation of membrane permeability IMP
IMP: Inferred from mutant phenotype
30813222 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18184445 RGD
involved in skeletal muscle tissue development IEP
IEP: Inferred from expression pattern
8846777 RGD
involved in tongue development IEP
IEP: Inferred from expression pattern
10908606 RGD
Cellular Component GO Annotation Evidence Reference Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
16859650 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
7589796 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Erbb3 Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (55 - 166)

Furin-like

Furin-like: pfam00757 (181 - 328)

Recep_L_domain

Recep_L_domain: pfam01030 (352 - 473)

GF_recep_IV

GF_recep_IV: pfam14843 (498 - 629)

TM_ErbB3

TM_ErbB3: cd12095 (637 - 673)

PKc_like

PKc_like: cl21453 (698 - 976)

  • 0
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  • 1200
  • 1339 a.a.
Protein Preferred Names Protein Names

receptor tyrosine-protein kinase erbB-3

avian erythroblastosis oncogene B 3

c-erbB-3

c-erbB3

proto-oncogene-like protein c-ErbB-3

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

Recombinant Erbb3 Proteins

Cat. No. Product Name Accession Purity
HY-P74892 HER3 Protein, Rat (HEK293, Fc) G3V6N1 (S20-H641) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Erbb3 NCBI NCBI:2065
Mus musculus Erbb3 NCBI NCBI:13867
Macaca mulatta Erbb3 NCBI NCBI:711407