Erbb3 - erb-b2 receptor tyrosine kinase 3 Gene

Mus musculus

Also known as Her3; Erbb-3; Erbb3r

Gene ID: 13867 | Gene type: protein coding

About Erbb3

Chromosome 10: 128,403,392-128,425,521 reverse strand.GRCm39:CM001003.3

This gene has 1 transcript (splice variant), 280 orthologues, 53 paralogues and is associated with 81 phenotypes. Biased expression in colon adult (RPKM 49.8), large intestine adult (RPKM 38.8) and 13 other tissues.

Summary

Predicted to enable several functions, including ErbB-3 class receptor binding activity; neuregulin binding activity; and transmembrane signaling receptor activity. Acts upstream of or within several processes, including nervous system development; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cardiac muscle tissue development. Located in apical plasma membrane and lateral plasma membrane. Is expressed in several structures, including alimentary system; heart; nervous system; reproductive system; and sensory organ epithelium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Erbb3 Products(1)

mRNA	Protein	Name
NM_010153.2	NP_034283.1	receptor tyrosine-protein kinase erbB-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neuregulin receptor activity	IMP IMP: Inferred from mutant phenotype	18760695	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11276227	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	8702723	MGI
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	9742126	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERBB2-ERBB3 signaling pathway	IDA IDA: Inferred from direct assay	8702723	MGI
involved in ERBB2-ERBB3 signaling pathway	IMP IMP: Inferred from mutant phenotype	18760695	MGI
involved in Schwann cell development	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within Schwann cell differentiation	IMP IMP: Inferred from mutant phenotype	9338783	MGI
acts upstream of or within cranial nerve development	IMP IMP: Inferred from mutant phenotype	9338783	MGI
acts upstream of or within endocardial cushion development	IMP IMP: Inferred from mutant phenotype	9362461	MGI
acts upstream of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9338783	MGI
involved in myelination	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within negative regulation of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9338783	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9338783	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9338783	MGI
acts upstream of or within peripheral nervous system development	IMP IMP: Inferred from mutant phenotype	9362461	MGI
acts upstream of or within positive regulation of calcineurin-NFAT signaling cascade	IGI IGI: Inferred from genetic interaction	19179536	MGI
acts upstream of or within positive regulation of cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	24364879	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24364879	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15306553	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	15306553	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	8702723	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Erbb3 Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

GF_recep_IV

TM_ErbB3

PKc_like

0
300
600
900
1200
1339 a.a.

Protein Preferred Names

Protein Names

receptor tyrosine-protein kinase erbB-3

avian erythroblastosis oncogene B 3 receptor	c-erbB-3
glial growth factor receptor	proto-oncogene-like protein c-ErbB-3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

Erbb3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Erbb3	Q61526	Erbb2	Mus musculus	P70424	Anti Bait CoIP	20639901

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Erbb3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70857	HER3 Protein, Mouse (HEK293, His)	Q61526 (S20-H641)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-118998	TX2-121-1	Inhibitor	/	Phase 3
HY-13050	Sapitinib	Inhibitor	99.93%	Phase 2

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99275	Patritumab	Inhibitor	98.95%	Phase 3
HY-P99268	Seribantumab		≥95.0%	Phase 2
HY-P99866	Duligotuzumab		97.93%	Phase 2
HY-P99672	Istiratumab	Inhibitor	/	Phase 2
HY-P99304	Lumretuzumab	Inhibitor	≥99.0%	Phase 1
HY-P99461	Barecetamab	Inhibitor	97.96%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100848	TX1-85-1	Inhibitor	98.04%	Unkown
HY-18609	PD158780	Inhibitor	99.56%	Unkown
HY-W006886	Fmoc-(R)-2-(7-octenyl)Ala-OH		98.85%	Unkown
HY-13050A	Sapitinib fumarate	Inhibitor	/	Unkown
HY-RS04469	ERBB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04470	Erbb3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04471	Erbb3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-164548	WK88-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Erbb3	NCBI	NCBI:2065
Rattus norvegicus	Erbb3	NCBI	NCBI:29496
Macaca mulatta	Erbb3	NCBI	NCBI:711407

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