S100a1 - S100 calcium binding protein A1 Gene

Rattus norvegicus

Gene ID: 295214 | Gene type: protein coding

About S100a1

Summary

Enables calcium ion binding activity; calcium-dependent protein binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of voltage-gated Calcium Channel activity. Located in M band; Z disc; and neuron projection. Orthologous to human S100A1 (S100 calcium binding protein A1). [provided by Alliance of Genome Resources, Apr 2022]

S100a1 Products(1)

mRNA	Protein	Name
NM_001007636.3	NP_001007637.1	protein S100-A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	16169012	RGD
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	10567243	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16169012	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14638689	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12619862	RGD
involved in positive regulation of voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	19657060	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in A band	IDA IDA: Inferred from direct assay	11156445	RGD
located in I band	IDA IDA: Inferred from direct assay	11156445	RGD
located in M band	IDA IDA: Inferred from direct assay	11156445	RGD
located in Z disc	IDA IDA: Inferred from direct assay	11156445	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein S100-A1

S-100 protein alpha chain

S-100 protein subunit alpha

S100a1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	S100a1	P35467	FKBP4	Homo sapiens	Q02790	Anti Bait CoIP	14638689
Cross	S100a1	P35467	FKBP4	Homo sapiens	Q02790	SPR	14638689
Cross	S100a1	P35467	HSP90AA1	Homo sapiens	P07900	SPR	14638689
Cross	S100a1	P35467	HSP90AA1	Homo sapiens	P07900	Anti Bait CoIP	14638689
Cross	S100a1	P35467	HSP90AA1	Homo sapiens	P07900	Pull Down	14638689
Cross	S100a1	P35467	HSPA1A	Homo sapiens	P08107	SPR	14638689
Cross	S100a1	P35467	PPID	Bos taurus	P26882	Anti Bait CoIP	14638689
Cross	S100a1	P35467	PPID	Bos taurus	P26882	Pull Down	14638689

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146695	S100P-IN-1	Inhibitor	99.74%	Unkown
HY-103636	PROTAC Sirt2 Degrader-1	Inhibitor	98.71%	Unkown
HY-16918A	Heptamidine dimethanesulfonate	Inhibitor	99.82%	Unkown
HY-16918	Heptamidine	Inhibitor	/	Unkown
HY-RS12371	S100A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S100a1	NCBI	NCBI:6271
Mus musculus	S100a1	NCBI	NCBI:20193

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