Aldh2 - aldehyde dehydrogenase 2 family member Gene

Rattus norvegicus

Gene ID: 29539 | Gene type: protein coding

About Aldh2

Primary_assembly 12: 34,901,219-34,982,521 forward strand.mRatBN7.2:CM026985.1

This gene has 7 transcripts (splice variants), 224 orthologues and 20 paralogues. Biased expression in Liver (RPKM 1581.), Adrenal (RPKM 143.4) and 9 other tissues.

Summary

Enables NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Involved in several processes, including behavioral response to ethanol; cellular response to resveratrol; and response to ischemia. Located in mitochondrial matrix. Biomarker of heart disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Apr 2022]

Aldh2 Products(1)

mRNA	Protein	Name
NM_032416.2	NP_115792.2	aldehyde dehydrogenase, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NADH binding	IDA IDA: Inferred from direct assay	21276780	RGD
enables aldehyde dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	4149764	RGD
enables aldehyde dehydrogenase (NAD+) activity	IMP IMP: Inferred from mutant phenotype	18787169	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	1898068	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	23403928	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acetaldehyde metabolic process	IMP IMP: Inferred from mutant phenotype	11535626	RGD
involved in apoptotic mitochondrial changes	IEP IEP: Inferred from expression pattern	30131474	RGD
involved in behavioral response to ethanol	IMP IMP: Inferred from mutant phenotype	11535626	RGD
involved in cellular detoxification of aldehyde	IMP IMP: Inferred from mutant phenotype	29589772	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	11463352	RGD
involved in cellular response to hormone stimulus	IEP IEP: Inferred from expression pattern	8749803	RGD
involved in cellular response to resveratrol	IEP IEP: Inferred from expression pattern	28688179	RGD
involved in ethanol metabolic process	IEP IEP: Inferred from expression pattern	28688179	RGD
involved in intrinsic apoptotic signaling pathway in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	29589772	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	16291827	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21123025	RGD
involved in regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	29589772	RGD
involved in regulation of response to oxidative stress	IEP IEP: Inferred from expression pattern	30131474	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	16339744	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	28688179	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	16782756	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	30131474	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	11578593	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	12359213	RGD
involved in response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	29589772	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	8749803	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	8749803	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	29491208	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aldh2 Protein Structure

ALDH_F1AB_F2_RALDH1

0
100
200
300
400
519 a.a.

Protein Preferred Names

Protein Names

aldehyde dehydrogenase, mitochondrial

ALDH class 2	ALDH-E2
ALDH1	aldehyde dehydrogenase 2 family (mitochondrial)
aldehyde dehydrogenase 2, mitochondrial	mitochondrial aldehyde dehydrogenase

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0364A	Dyclonine hydrochloride	Inhibitor	99.86%	Unkown

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113466	4-Hydroxynonenal	Inhibitor	99.35%	Unkown
HY-18936	Alda-1	Agonist	99.99%	Unkown
HY-19801	CVT-10216	Inhibitor	99.87%	Unkown
HY-146683	KS106	Inhibitor	99.31%	Unkown
HY-76006	3-Hydroxybenzaldehyde		99.85%	Unkown
HY-113466S	4-Hydroxynonenal-d3	Inhibitor	≥99.0%	Unkown
HY-126241	RV01	Inhibitor	98.0%	Unkown
HY-148617	ALDH2 modulator 1	Modulator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aldh2	NCBI	NCBI:217

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