KS106

Name: KS106
Brand: MedChemExpress
SKU: HY-146683
Rating: 4.5 (1 reviews)

Cat. No.: HY-146683 Purity: 99.31%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

KS106 is a potent ALDH inhibitor with IC₅₀s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase.

For research use only. We do not sell to patients.

KS106 Chemical Structure

CAS No. : 2408477-50-7

Size	Price	Stock	Quantity
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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View All Aldehyde Dehydrogenase (ALDH) Isoform Specific Products:

View All Isoforms

ALDH1 ALDH2 ALDH3

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

ALDH2

2137 nM (IC₅₀)

ALDH1A1

334 nM (IC₅₀)

ALDH3A1

360 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	5.7 μM Compound: 3h; KS106	Antiproliferative activity against human HCT116 cells measured after 72 hrs by MTS assay Antiproliferative activity against human HCT116 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
HT-29	IC₅₀	4.9 μM Compound: 3h; KS106	Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTS assay Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
MM1.S	IC₅₀	2.2 μM Compound: 3h; KS106	Antiproliferative activity against human MM.1S cells measured after 72 hrs by MTS assay Antiproliferative activity against human MM.1S cells measured after 72 hrs by MTS assay	[PMID: 31887569]
NCI-H929	IC₅₀	1.5 μM Compound: 3h; KS106	Antiproliferative activity against human NCIH929 cells measured after 72 hrs by MTS assay Antiproliferative activity against human NCIH929 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
RPMI-8226	IC₅₀	1.6 μM Compound: 3h; KS106	Antiproliferative activity against human RPMI8226 cells measured after 72 hrs by MTS assay Antiproliferative activity against human RPMI8226 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
U-266	IC₅₀	2.6 μM Compound: 3h; KS106	Antiproliferative activity against human U266 cells measured after 72 hrs by MTS assay Antiproliferative activity against human U266 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
UACC-903	IC₅₀	5.7 μM Compound: 3h; KS106	Antiproliferative activity against human UACC 903 cells measured after 72 hrs by MTS assay Antiproliferative activity against human UACC 903 cells measured after 72 hrs by MTS assay	[PMID: 31887569]

In Vitro

KS106 (compound 3h) (0-100 µM; 72 h) shows anti-proliferative activity with IC₅₀s of 5.7, 5.7, 5.7, 4.9, 1.5, 2.6, 1.6, 1.7, 2.2, 20.7 µM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively^[1].
KS106 (5 µM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	HCT116, HT29 cells
Concentration:	5 µM
Incubation Time:	24 h
Result:	Induced cell apoptosis.

Cell Cycle Analysis^[1]

Cell Line:	HCT116 cells
Concentration:	5 µM
Incubation Time:	24 h
Result:	Induced cell cycle arrest at G2/M phase.

Molecular Weight

474.29

Formula

C₁₈H₁₅BrF₃N₃O₂S

CAS No.

2408477-50-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

N=C(SCC1=CC=C(C=C1)CN2C(C(C3=CC(C(F)(F)F)=CC=C32)=O)=O)N.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (210.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1084 mL	10.5421 mL	21.0841 mL
5 mM	0.4217 mL	2.1084 mL	4.2168 mL
10 mM	0.2108 mL	1.0542 mL	2.1084 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.31%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (249 KB) HNMR (221 KB) CNMR (226 KB) RP-HPLC (254 KB) MS (75 KB)

Handling Instructions (2659 KB)

References

[1]. Dinavahi SS, et al. Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents. Eur J Med Chem. 2020 Feb 1;187:111962. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1084 mL	10.5421 mL	21.0841 mL	52.7104 mL
	5 mM	0.4217 mL	2.1084 mL	4.2168 mL	10.5421 mL
	10 mM	0.2108 mL	1.0542 mL	2.1084 mL	5.2710 mL
	15 mM	0.1406 mL	0.7028 mL	1.4056 mL	3.5140 mL
	20 mM	0.1054 mL	0.5271 mL	1.0542 mL	2.6355 mL
	25 mM	0.0843 mL	0.4217 mL	0.8434 mL	2.1084 mL
	30 mM	0.0703 mL	0.3514 mL	0.7028 mL	1.7570 mL
	40 mM	0.0527 mL	0.2636 mL	0.5271 mL	1.3178 mL
	50 mM	0.0422 mL	0.2108 mL	0.4217 mL	1.0542 mL
	60 mM	0.0351 mL	0.1757 mL	0.3514 mL	0.8785 mL
	80 mM	0.0264 mL	0.1318 mL	0.2636 mL	0.6589 mL
	100 mM	0.0211 mL	0.1054 mL	0.2108 mL	0.5271 mL

KS106 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KS1062408477-50-7KS 106KS-106Aldehyde Dehydrogenase (ALDH)Apoptosislow toxicantiproliferativeanticancerROS activitylipid peroxidationtoxic aldehyde accumulationapoptosisG2/M phaseHCT116 cellsInhibitorinhibitorinhibit

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KS106

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KS106 Related Antibodies

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KS106 Related Antibodies

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Complete Stock Solution Preparation Table

KS106 Related Classifications

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