2. Metabolic Enzyme/Protease Apoptosis
  3. Aldehyde Dehydrogenase (ALDH) Apoptosis
  4. KS106

KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase.

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KS106 Chemical Structure

KS106 Chemical Structure

CAS No. : 2408477-50-7

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5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

KS106 Related Antibodies

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ALDH1 ALDH2 ALDH3

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Description

KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase[1].

IC50 & Target

ALDH2

2137 nM (IC50)

ALDH1A1

334 nM (IC50)

ALDH3A1

360 nM (IC50)

In Vitro

KS106 (compound 3h) (0-100 µM; 72 h) shows anti-proliferative activity with IC50s of 5.7, 5.7, 5.7, 4.9, 1.5, 2.6, 1.6, 1.7, 2.2, 20.7 µM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively[1].
KS106 (5 µM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KS106 Related Antibodies

Apoptosis Analysis[1]

Cell Line: HCT116, HT29 cells
Concentration: 5 µM
Incubation Time: 24 h
Result: Induced cell apoptosis.

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 5 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G2/M phase.
Molecular Weight

474.29

Formula

C18H15BrF3N3O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N=C(SCC1=CC=C(C=C1)CN2C(C(C3=CC(C(F)(F)F)=CC=C32)=O)=O)N.Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (210.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1084 mL 10.5421 mL 21.0841 mL
5 mM 0.4217 mL 2.1084 mL 4.2168 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1084 mL 10.5421 mL 21.0841 mL 52.7104 mL
5 mM 0.4217 mL 2.1084 mL 4.2168 mL 10.5421 mL
10 mM 0.2108 mL 1.0542 mL 2.1084 mL 5.2710 mL
15 mM 0.1406 mL 0.7028 mL 1.4056 mL 3.5140 mL
20 mM 0.1054 mL 0.5271 mL 1.0542 mL 2.6355 mL
25 mM 0.0843 mL 0.4217 mL 0.8434 mL 2.1084 mL
30 mM 0.0703 mL 0.3514 mL 0.7028 mL 1.7570 mL
40 mM 0.0527 mL 0.2636 mL 0.5271 mL 1.3178 mL
50 mM 0.0422 mL 0.2108 mL 0.4217 mL 1.0542 mL
60 mM 0.0351 mL 0.1757 mL 0.3514 mL 0.8785 mL
80 mM 0.0264 mL 0.1318 mL 0.2636 mL 0.6589 mL
100 mM 0.0211 mL 0.1054 mL 0.2108 mL 0.5271 mL
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KS106 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KS1062408477-50-7KS 106KS-106Aldehyde Dehydrogenase (ALDH)Apoptosislow toxicantiproliferativeanticancerROS activitylipid peroxidationtoxic aldehyde accumulationapoptosisG2/M phaseHCT116 cellsInhibitorinhibitorinhibit

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