Gria2 - glutamate ionotropic receptor AMPA type subunit 2 Gene

Rattus norvegicus

Also known as GluA2; GluR2; gluR-B; GluR-K2

Gene ID: 29627 | Gene type: protein coding

About Gria2

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to CA(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene. [provided by RefSeq, Jul 2008]

Gria2 Products(2)

mRNA	Protein	Name
NM_001083811.1	NP_001077280.1	glutamate receptor 2 isoform 2 precursor
NM_017261.2	NP_058957.1	glutamate receptor 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables AMPA glutamate receptor activity	IDA IDA: Inferred from direct assay	19265014	RGD
enables PDZ domain binding	IDA IDA: Inferred from direct assay	10558890	RGD
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	9697854	RGD
enables SNARE binding	IPI IPI: Inferred from physical interaction	11931741	RGD
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	20032460	RGD
enables cytoskeletal protein binding	IPI IPI: Inferred from physical interaction	18297063	RGD
enables extracellular ligand-gated monoatomic ion channel activity	IDA IDA: Inferred from direct assay	1653450	RGD
enables glutamate receptor binding	IPI IPI: Inferred from physical interaction	21639859	RGD
enables glutamate-gated calcium ion channel activity	IDA IDA: Inferred from direct assay	11773314	RGD
enables glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	19946266	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	19461580	RGD
enables immunoglobulin binding	IPI IPI: Inferred from physical interaction	26595655	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	10414981	RGD
enables kainate selective glutamate receptor activity	IDA IDA: Inferred from direct assay	21846932	RGD
enables ligand-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	11773314	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	10704491	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	10704491	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9647694	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17329210	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	21847098	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	10414981	RGD
enables signaling receptor activity	IDA IDA: Inferred from direct assay	11348590	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	11348590	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	11348590	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to brain-derived neurotrophic factor stimulus	IDA IDA: Inferred from direct assay	14597197	RGD
involved in cellular response to glycine	IDA IDA: Inferred from direct assay	21847098	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	14597197	RGD
involved in chemical synaptic transmission	IDA IDA: Inferred from direct assay	12554656	RGD
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	11348590	RGD
involved in positive regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	11348590	RGD
involved in protein tetramerization	IDA IDA: Inferred from direct assay	19946266	RGD
involved in receptor internalization	IDA IDA: Inferred from direct assay	11100149	RGD
involved in regulation of receptor recycling	IMP IMP: Inferred from mutant phenotype	11348590	RGD
involved in regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	9697854	RGD
involved in response to fungicide	IEP IEP: Inferred from expression pattern	19591855	RGD
involved in response to lithium ion	IEP IEP: Inferred from expression pattern	15269270	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of AMPA glutamate receptor complex	IDA IDA: Inferred from direct assay	19265014	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	11348590	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	11348590	RGD
located in asymmetric synapse	IDA IDA: Inferred from direct assay	10701825	RGD
located in axon	IDA IDA: Inferred from direct assay	16157387	RGD
located in cell surface	IDA IDA: Inferred from direct assay	19321442	RGD
located in dendrite	IDA IDA: Inferred from direct assay	10701825	RGD
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	17207780	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	11931740	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	10414981	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	11348590	RGD
located in dendritic spine head	IDA IDA: Inferred from direct assay	11007883	RGD
located in dendritic spine neck	IDA IDA: Inferred from direct assay	11007883	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15610164	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12554656	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10414981	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	15844209	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	21846932	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	10701825	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	28057533	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	16903873	RGD
located in presynapse	IDA IDA: Inferred from direct assay	21807099	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	28057533	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	15610164	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	12554656	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17329210	RGD
part of protein-containing complex	IPI IPI: Inferred from physical interaction	10027300	RGD
located in spine synapse	IDA IDA: Inferred from direct assay	11007883	RGD
located in synapse	IDA IDA: Inferred from direct assay	10027300	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	12554656	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	15844209	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor 2

AMPA-selective glutamate receptor 2	glutamate receptor B
glutamate receptor, ionotropic, AMPA 2

Gria2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Gria2	P19491	Ap2m1	Rattus norvegicus	P84092	Pull Down	17289840
Intra	Gria2	P19491	Atad1	Rattus norvegicus	Q505J9	Pull Down	21496646
Intra	Gria2	P19491	Agap2	Rattus norvegicus	Q8CGU4	IF	21847098
Intra	Gria2	P19491	Agap2	Rattus norvegicus	Q8CGU4	Anti Bait CoIP	21847098
Intra	Gria2	P19491	Syt3	Rattus norvegicus	P40748	Pull Down	30545844
Cross	Gria2	P19491	PPFIA1	Homo sapiens	Q13136	Anti Bait CoIP	11931740
Intra	Gria2	P19491	Grip1	Rattus norvegicus	P97879	Anti Bait CoIP	21847098
Intra	Gria2	P19491	Grip1	Rattus norvegicus	P97879	Pull Down	11891216
Intra	Gria2	P19491	Grip1	Rattus norvegicus	P97879	Pull Down	21496646
Intra	Gria2	P19491	Pick1	Rattus norvegicus	Q9EP80	Anti Bait CoIP	10027300
Intra	Gria2	P19491	Grip1	Rattus norvegicus	P97879	Y2H	11891216
Intra	Gria2	P19491	Grip1	Rattus norvegicus	P97879	IF	16055064
Intra	Gria2	P19491	Pick1	Rattus norvegicus	Q9EP80	Y2H	11891216
Intra	Gria2	P19491	Pick1	Rattus norvegicus	Q9EP80	NMR	17914463
Intra	Gria2	P19491	Grip1	Rattus norvegicus	P97879	Anti Bait CoIP	11931740
Intra	Gria2	P19491	Pick1	Rattus norvegicus	Q9EP80	Pull Down	11891216
Intra	Gria2	P19491	Grip1	Rattus norvegicus	P97879	Y2H	9768844
Intra	Gria2	P19491	Pick1	Rattus norvegicus	Q9EP80	Pull Down	16055064
Intra	Gria2	P19491	Pick1	Rattus norvegicus	Q9EP80	Y2H	10027300
Intra	Gria2	P19491	Pick1	Rattus norvegicus	Q9EP80	CoIP	10340301
Intra	Gria2	P19491	Ppfia4	Rattus norvegicus	Q91Z80	Anti Bait CoIP	11931740
Intra	Gria2	P19491	Nsf	Rattus norvegicus	Q9QUL6	Y2H	9697854
Intra	Gria2	P19491	Grip2	Rattus norvegicus	Q9WTW1-3	Y2H	9768844
Intra	Gria2	P19491	Grip2	Rattus norvegicus	Q9WTW1-3	Anti Bait CoIP	9768844
Intra	Gria2	P19491	Grip2	Rattus norvegicus	Q9WTW1-3	Anti Tag CoIP	9768844

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05792	GRIA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gria2	NCBI	NCBI:2891

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