Gria3 - glutamate ionotropic receptor AMPA type subunit 3 Gene

Rattus norvegicus

Also known as GLUR3; GluA3; GluR-3; GluR-C; GluR-K3

Gene ID: 29628 | Gene type: protein coding

About Gria3

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]

Gria3 Products(2)

mRNA	Protein	Name
NM_001112742.1	NP_001106213.1	glutamate receptor 3 isoform 2 precursor
NM_032990.2	NP_116785.2	glutamate receptor 3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables AMPA glutamate receptor activity	IDA IDA: Inferred from direct assay	11834304	RGD
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	20032460	RGD
enables glutamate-gated calcium ion channel activity	IDA IDA: Inferred from direct assay	1709304	RGD
enables glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	1699567	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9647694	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of receptor recycling	IMP IMP: Inferred from mutant phenotype	11348590	RGD
involved in response to fungicide	IEP IEP: Inferred from expression pattern	19591855	RGD
involved in response to lithium ion	IEP IEP: Inferred from expression pattern	15269270	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of AMPA glutamate receptor complex	IDA IDA: Inferred from direct assay	19265014	RGD
located in asymmetric synapse	IDA IDA: Inferred from direct assay	12077196	RGD
located in dendrite	IDA IDA: Inferred from direct assay	15844209	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	12077196	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	11348590	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12761821	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12077196	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	15844209	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	10027300	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	12761821	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	16903873	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	25524891	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	12761821	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	16903873	RGD
part of protein-containing complex	IPI IPI: Inferred from physical interaction	10027300	RGD
located in synaptic cleft	IDA IDA: Inferred from direct assay	17207780	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	15844209	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor 3

AMPA-selective glutamate receptor 3	glutamate receptor, ionotrophic, AMPA 3
glutamate receptor, ionotropic, AMPA 3	glutamate receptor, ionotropic, AMPA3 (alpha 3)

Gria3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Gria3	P19492	Pick1	Rattus norvegicus	Q9EP80	Y2H	10340301
Intra	Gria3	P19492	Pick1	Rattus norvegicus	Q9EP80	Pull Down	11891216
Intra	Gria3	P19492	Pick1	Rattus norvegicus	Q9EP80	Y2H	10027300
Intra	Gria3	P19492	Grip1	Rattus norvegicus	P97879	Y2H	9647694
Intra	Gria3	P19492	Grip1	Rattus norvegicus	P97879	Y2H	11891216
Intra	Gria3	P19492	Grip1	Rattus norvegicus	P97879	Pull Down	11891216

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05793	GRIA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gria3	NCBI	NCBI:2892

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