MAGOHB - mago homolog B, exon junction complex subunit Gene

Homo sapiens

Also known as MGN2; mago; magoh

Gene ID: 55110 | Gene type: protein coding

About MAGOHB

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,599,524-10,613,609 (from NCBI)

This gene has 11 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 3.2), appendix (RPKM 3.0) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in nucleus. Part of U2-type catalytic step 1 spliceosome; U2-type precatalytic spliceosome; and exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

MAGOHB Products(3)

mRNA	Protein	Name
NM_001300739.2	NP_001287668.1	protein mago nashi homolog 2 isoform 2
NM_001319985.2	NP_001306914.1	protein mago nashi homolog 2 isoform 2
NM_018048.5	NP_060518.1	protein mago nashi homolog 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28502770	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IGI IGI: Inferred from genetic interaction	23917022	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type catalytic step 1 spliceosome	IDA IDA: Inferred from direct assay	29301961	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28502770	GOA
part of exon-exon junction complex	IDA IDA: Inferred from direct assay	23917022	GOA
part of exon-exon junction subcomplex mago-y14	IPI IPI: Inferred from physical interaction	25416956	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28502770	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGOHB Protein Structure

Mago_nashi

0
100
148 a.a.

Protein Preferred Names

Protein Names

protein mago nashi homolog 2

mago homolog B, exon junction complex core component

Related Diseases

Diseases

Alias

Metaphyseal Chondrodysplasia, Schmid Type

MCDS	Schmid Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia Schmid Type	Spondylometaphyseal Dysplasia, Japanese Type
Japanese Type Spondylometaphyseal Dysplasia	Schmid Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia Type Schmid	Schmid Type Metaphyseal Chondrodysplasia
SMCD	Chondrodysplasia, Metaphyseal, Schmid Type
Corneal Dystrophy, Subepithelial Mucinous

Treacher Collins Syndrome 1

Treacher Collins Syndrome	Mandibulofacial Dysostosis
Treacher Collins-Franceschetti Syndrome	Tcof
Tcs	Mfd1
Franceschetti-Klein Syndrome	TCS1
Franceschetti Syndrome	Franceschetti-Zwahlen-Klein Syndrome
Zygoauromandibular Dysplasia	Treacher-Collins Syndrome
Mandibulofacial Dysostosis Without Limb Anomalies	Bilateral And Symmetric Oto-Mandibular Dysplasia

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07986	MAGOHB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAGOHB	MGD	MGI:1913691
Rattus norvegicus	MAGOHB	RGD	RGD:1597384

Name
Email *

	Sorry, but the email address you supplied was invalid.