2. Gene
  3. ST8SIA5 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 Gene

ST8SIA5 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SIAT8E; SIAT8-E; ST8SiaV

Gene ID: 29906 | Gene type: protein coding

About ST8SIA5

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:46,667,821-46,757,053 (from NCBI)

This gene has 9 transcripts (splice variants), 197 orthologues and 5 paralogues. Biased expression in adrenal (RPKM 3.3), brain (RPKM 3.3) and 3 other tissues.

Summary

The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded protein, which is a member of Glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. [provided by RefSeq, Jul 2008]

ST8SIA5 Products(3)

mRNA Protein Name
NM_001307986.2 NP_001294915.1 alpha-2,8-sialyltransferase 8E isoform 1
NM_001307987.2 NP_001294916.1 alpha-2,8-sialyltransferase 8E isoform 3
NM_013305.6 NP_037437.2 alpha-2,8-sialyltransferase 8E isoform 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST8SIA5 Protein Structure

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (115 - 371)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
Protein Preferred Names Protein Names

alpha-2,8-sialyltransferase 8E

ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 5

ST8SIA5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ST8SIA5 O15466 SELENON Homo sapiens Q9NZV5
Anti Tag CoIP
33961781
Intra
ST8SIA5 O15466 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13859 ST8SIA5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ST8SIA5 VGNC VGNC:77942
Felis catus ST8SIA5 VGNC VGNC:65738
Canis familiaris ST8SIA5 VGNC VGNC:46867
Mus musculus ST8SIA5 MGD MGI:109243
Rattus norvegicus ST8SIA5 RGD RGD:1302934
Bos taurus ST8SIA5 VGNC VGNC:54494