SNX15 - sorting nexin 15 Gene

Homo sapiens

Also known as HSAF001435

Gene ID: 29907 | Gene type: protein coding

About SNX15

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,027,439-65,040,572 (from NCBI)

This gene has 7 transcripts (splice variants), 182 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 9.4), kidney (RPKM 8.6) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of Insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of Furin, the endoprotease responsible for cleavage of Insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]

SNX15 Products(2)

mRNA	Protein	Name
NM_013306.5	NP_037438.2	sorting nexin-15 isoform A
NM_147777.4	NP_680086.2	sorting nexin-15 isoform B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX15 Protein Structure

MIT

0
100
200
300
342 a.a.

Protein Preferred Names

Protein Names

sorting nexin-15

clone iota unknown protein

Related Diseases

Diseases

Alias

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13528	SNX15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SNX15	MGD	MGI:1916274
Canis familiaris	SNX15	VGNC	VGNC:46624
Macaca mulatta	SNX15	VGNC	VGNC:107646
Rattus norvegicus	SNX15	RGD	RGD:1305803
Bos taurus	SNX15	VGNC	VGNC:35095
Felis catus	SNX15	VGNC	VGNC:81935

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