2. Gene
  3. GET3 - guided entry of tail-anchored proteins factor 3, ATPase Gene

GET3 - guided entry of tail-anchored proteins factor 3, ATPase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARSA1; ASNA1; TRC40; ARSA-I; ASNA-I

Gene ID: 439 | Gene type: protein coding

About GET3

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,737,106-12,748,323 (from NCBI)

This gene has 3 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in kidney (RPKM 39.3), thyroid (RPKM 34.9) and 25 other tissues.

Summary

This gene represents the human homolog of the Bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

GET3 Products(3)

mRNA Protein Name
NM_001371488.1 NP_001358417.1 ATPase GET3
NM_001371489.1 NP_001358418.1 ATPase GET3
NM_004317.4 NP_004308.2 ATPase GET3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables membrane insertase activity IDA
IDA: Inferred from direct assay
23610396 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
Biological Process GO Annotation Evidence Reference Source
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
25535373 GOA
involved in tail-anchored membrane protein insertion into ER membrane IMP
IMP: Inferred from mutant phenotype
23041287 GOA
Cellular Component GO Annotation Evidence Reference Source
part of GET complex IDA
IDA: Inferred from direct assay
32910895 GOA
part of GET complex IPI
IPI: Inferred from physical interaction
23041287 GOA
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
32910895 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GET3 Protein Structure

ArsA_ATPase

ArsA_ATPase: Anion-transporting ATPase (38 - 339)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
Protein Preferred Names Protein Names

ATPase GET3

arsA arsenite transporter, ATP-binding, homolog 1

GET3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GET3 O43681 PDIA6 Homo sapiens Q15084
Y2H Prey Pooling
32296183
Intra
GET3 O43681 PDIA6 Homo sapiens Q15084
Validated Y2H
32296183
Intra
GET3 O43681 PDIA6 Homo sapiens Q15084
Y2H Array
32296183
Intra
GET3 O43681 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
GET3 O43681 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
GET3 O43681 TMX1 Homo sapiens Q9H3N1
Validated Y2H
32296183
Intra
GET3 O43681 TMX1 Homo sapiens Q9H3N1
Y2H Prey Pooling
32296183
Intra
GET3 O43681 TMX1 Homo sapiens Q9H3N1
Y2H Array
32296183
Intra
GET3 O43681 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
GET3 O43681 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
GET3 O43681 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
GET3 O43681 KCNE4 Homo sapiens Q8WWG9
Validated Y2H
32296183
Intra
GET3 O43681 KCNE4 Homo sapiens Q8WWG9
Y2H Prey Pooling
32296183
Intra
GET3 O43681 KCNE4 Homo sapiens Q8WWG9
Y2H Array
32296183
Intra
GET3 O43681 FAM163A Homo sapiens Q96GL9
Y2H Prey Pooling
32296183
Intra
GET3 O43681 FAM163A Homo sapiens Q96GL9
Validated Y2H
32296183
Intra
GET3 O43681 FAM163A Homo sapiens Q96GL9
Y2H Array
32296183
Intra
GET3 O43681 VWC2 Homo sapiens Q2TAL6
Validated Y2H
32296183
Intra
GET3 O43681 VWC2 Homo sapiens Q2TAL6
Y2H Array
32296183
Intra
GET3 O43681 VWC2 Homo sapiens Q2TAL6
Y2H Prey Pooling
32296183
Intra
GET3 O43681 KCNE5 Homo sapiens Q9UJ90
Y2H Array
32296183
Intra
GET3 O43681 KCNE5 Homo sapiens Q9UJ90
Y2H Prey Pooling
32296183
Intra
GET3 O43681 KCNE5 Homo sapiens Q9UJ90
Validated Y2H
32296183
Intra
GET3 O43681 EMSY Homo sapiens Q7Z589-5
Validated Y2H
32296183
Intra
GET3 O43681 EMSY Homo sapiens Q7Z589-5
Y2H Array
32296183
Intra
GET3 O43681 EMSY Homo sapiens Q7Z589-5
Y2H Prey Pooling
32296183
Intra
GET3 O43681 ASPH Homo sapiens Q12797-6
Validated Y2H
32296183
Intra
GET3 O43681 LDLRAD4 Homo sapiens O15165-2
Y2H Array
32296183
Intra
GET3 O43681 LDLRAD4 Homo sapiens O15165-2
Y2H Prey Pooling
32296183
Intra
GET3 O43681 TMEM154 Homo sapiens Q6P9G4
Y2H Prey Pooling
32296183
Intra
GET3 O43681 TMEM154 Homo sapiens Q6P9G4
Validated Y2H
32296183
Intra
GET3 O43681 TMEM154 Homo sapiens Q6P9G4
Y2H Array
32296183
Intra
GET3 O43681 PRB3 Homo sapiens Q04118
Y2H Prey Pooling
32296183
Intra
GET3 O43681 PRB3 Homo sapiens Q04118
Validated Y2H
32296183
Intra
GET3 O43681 PRB3 Homo sapiens Q04118
Y2H Array
32296183
Intra
GET3 O43681 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
GET3 O43681 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
GET3 O43681 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
GET3 O43681 CAMLG Homo sapiens P49069
Y2H Prey Pooling
32296183
Intra
GET3 O43681 CAMLG Homo sapiens P49069
Complementation
32296183
Intra
GET3 O43681 CAMLG Homo sapiens P49069
Anti Tag CoIP
33961781
Intra
GET3 O43681 CAMLG Homo sapiens P49069
Y2H Array
32296183
Intra
GET3 O43681 CAMLG Homo sapiens P49069
Validated Y2H
32296183
Intra
GET3 O43681 SMIM19 Homo sapiens Q96E16
Y2H Array
32296183
Intra
GET3 O43681 SMIM19 Homo sapiens Q96E16
Validated Y2H
32296183
Intra
GET3 O43681 SMIM19 Homo sapiens Q96E16
Y2H Prey Pooling
32296183
Intra
GET3 O43681 SYPL2 Homo sapiens Q5VXT5-2
Y2H Prey Pooling
32296183
Intra
GET3 O43681 SYPL2 Homo sapiens Q5VXT5-2
Validated Y2H
32296183
Intra
GET3 O43681 SYPL2 Homo sapiens Q5VXT5-2
Y2H Array
32296183
Intra
GET3 O43681 RHEX Homo sapiens Q6ZWK4
Y2H Prey Pooling
32296183
Intra
GET3 O43681 RHEX Homo sapiens Q6ZWK4
Y2H Array
32296183
Intra
GET3 O43681 RHEX Homo sapiens Q6ZWK4
Validated Y2H
32296183
Intra
GET3 O43681 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
GET3 O43681 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
GET3 O43681 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
GET3 O43681 CSPG5 Homo sapiens O95196-2
Validated Y2H
32296183
Intra
GET3 O43681 CSPG5 Homo sapiens O95196-2
Y2H Prey Pooling
32296183
Intra
GET3 O43681 CSPG5 Homo sapiens O95196-2
Y2H Array
32296183
Intra
GET3 O43681 ASPH Homo sapiens Q12797
Y2H Prey Pooling
25416956
Intra
GET3 O43681 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
GET3 O43681 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
GET3 O43681 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
GET3 O43681 CREB3L4 Homo sapiens Q8TEY5
Validated Y2H
32296183
Intra
GET3 O43681 CREB3L4 Homo sapiens Q8TEY5
Y2H Array
32296183
Intra
GET3 O43681 CREB3L4 Homo sapiens Q8TEY5
Y2H Prey Pooling
32296183
Intra
GET3 O43681 PEX14 Homo sapiens O75381
Y2H Prey Pooling
32296183
Intra
GET3 O43681 PEX14 Homo sapiens O75381
Validated Y2H
32296183
Intra
GET3 O43681 PEX14 Homo sapiens O75381
Y2H Array
32296183
Cross
GET3 O43681 yscD Yersinia pestis Q56975
Y2H Array
21911467
Intra
GET3 O43681 GET4 Homo sapiens Q7L5D6
Y2H Array
32296183
Intra
GET3 O43681 GET4 Homo sapiens Q7L5D6
Validated Y2H
32296183
Intra
GET3 O43681 GET4 Homo sapiens Q7L5D6
Y2H Prey Pooling
32296183
Intra
GET3 O43681 GET4 Homo sapiens Q7L5D6
Y2H
21516116
Intra
GET3 O43681 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
GET3 O43681 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
Intra
GET3 O43681 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
GET3 O43681 AGR2 Homo sapiens O95994
Validated Y2H
32296183
Intra
GET3 O43681 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra
GET3 O43681 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra
GET3 O43681 SPP1 Homo sapiens P10451
Y2H Prey Pooling
32296183
Intra
GET3 O43681 SPP1 Homo sapiens P10451
Validated Y2H
32296183
Intra
GET3 O43681 SPP1 Homo sapiens P10451
Y2H Array
32296183
Intra
GET3 O43681 TMEM51 Homo sapiens Q9NW97
Validated Y2H
32296183
Intra
GET3 O43681 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra
GET3 O43681 PRR4 Homo sapiens Q16378
Y2H Array
32296183
Intra
GET3 O43681 PRR4 Homo sapiens Q16378
Y2H Prey Pooling
32296183
Intra
GET3 O43681 PRR4 Homo sapiens Q16378
Validated Y2H
32296183
Intra
GET3 O43681 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
GET3 O43681 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
GET3 O43681 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
GET3 O43681 GPX7 Homo sapiens Q96SL4
Validated Y2H
32296183
Intra
GET3 O43681 GPX7 Homo sapiens Q96SL4
Y2H Array
32296183
Intra
GET3 O43681 GPX7 Homo sapiens Q96SL4
Y2H Array
25416956
Intra
GET3 O43681 GPX7 Homo sapiens Q96SL4
Y2H Prey Pooling
32296183
Intra
GET3 O43681 WFDC3 Homo sapiens Q8IUB2
Validated Y2H
32296183
Intra
GET3 O43681 WFDC3 Homo sapiens Q8IUB2
Y2H Prey Pooling
32296183
Intra
GET3 O43681 WFDC3 Homo sapiens Q8IUB2
Y2H Array
32296183
Intra
GET3 O43681 IGFBP6 Homo sapiens P24592
Y2H Array
32296183
Intra
GET3 O43681 IGFBP6 Homo sapiens P24592
Y2H Prey Pooling
32296183
Intra
GET3 O43681 IGFBP6 Homo sapiens P24592
Validated Y2H
32296183
Intra
GET3 O43681 RCN1 Homo sapiens Q15293
Y2H Array
32296183
Intra
GET3 O43681 RCN1 Homo sapiens Q15293
Y2H Prey Pooling
32296183
Intra
GET3 O43681 RCN1 Homo sapiens Q15293
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Adenoma

Ademoma - Breast
Nephronophthisis 1

NPHP1

Nephronophthisis, Familial Juvenile

Nph1

Nephronophthisis 1, Juvenile

Juvenile Nephronophthisis 1

Familial Juvenile Nephronophthisis 1

Nephronophthisis, Type 1
Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder

Infantile Refsum Disease

Infantile Phytanic Acid Storage Disease

PBD1B

Refsum Disease, Infantile

Adrenoleukodystrophy, Autosomal Neonatal

Ird

Mild Pbd-Zsd

Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Pbd-Zsd

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Autosomal Neonatal Adrenoleukodystrophy

Refsum Disease Infantile

Peroxisome Biogenesis Disorders

Peroxisome Biogenesis Disorder, Type 1b
Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders

Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum

Disorders Of Peroxisome Biogenesis

Zellweger Spectrum

Zellweger Syndrome Spectrum

Peroxisomal Biogenesis Disorders

Pbd, Zss

Pbd-Zsd

Pbd-Zss

Pbd-Zellweger Spectrum Disorder

Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum

Peroxisome Biogenesis Disorder

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorders

Zellweger Spectrum Disorder

Hyperpipecolic Acidaemia
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05374 GET3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GET3 MGD MGI:1928379
Rattus norvegicus GET3 RGD RGD:1307906
Felis catus GET3 VGNC VGNC:80262
Macaca mulatta GET3 VGNC VGNC:80258
Bos taurus GET3 VGNC VGNC:96696
Canis familiaris GET3 VGNC VGNC:102781