STRN3 - striatin 3 Gene

Homo sapiens

Also known as SG2NA; S/G2NA; PPP2R6B

Gene ID: 29966 | Gene type: protein coding

About STRN3

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:30,893,804-31,026,379 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 11.4), fat (RPKM 8.6) and 25 other tissues.

Summary

Enables armadillo repeat domain binding activity; protein Phosphatase 2A binding activity; and small GTPase binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; nucleoplasm; and plasma membrane. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2022]

STRN3 Products(2)

mRNA	Protein	Name
NM_001083893.2	NP_001077362.1	striatin-3 isoform 1
NM_014574.4	NP_055389.3	striatin-3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables armadillo repeat domain binding	IPI IPI: Inferred from physical interaction	18502210	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18782753	GOA
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	18782753	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18782753	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	30622739	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	25743393	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11570823	GOA
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	30622739	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11570823	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11570823	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	18782753	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11251078	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18434427	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	11570823	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18434427	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11251078	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STRN3 Protein Structure

Striatin

WD40

0
200
400
600
797 a.a.

Protein Preferred Names

Protein Names

striatin-3

cell cycle S/G2 nuclear autoantigen

STRN3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STRN3	Q13033	STRN	Homo sapiens	O43815	Anti Tag CoIP	18782753
Intra	STRN3	Q13033	STRN	Homo sapiens	O43815	Anti Tag CoIP	35271311
Intra	STRN3	Q13033	STRN	Homo sapiens	O43815	Anti Tag CoIP	24366813
Intra	STRN3	Q13033	STRN	Homo sapiens	O43815	Anti Bait CoIP	18782753
Intra	STRN3	Q13033	STRN	Homo sapiens	O43815	Anti Tag CoIP	26496610
Intra	STRN3	Q13033	STRN	Homo sapiens	O43815	BioID	24255178
Intra	STRN3	Q13033	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	18782753
Intra	STRN3	Q13033	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	33961781
Intra	STRN3	Q13033	CTTNBP2NL	Homo sapiens	Q9P2B4	BioID	24255178
Intra	STRN3	Q13033	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Bait CoIP	18782753
Intra	STRN3	Q13033	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	24366813
Intra	STRN3	Q13033	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	26496610
Intra	STRN3	Q13033	MOB4	Homo sapiens	Q9Y3A3-1	Anti Tag CoIP	33633399

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13967	STRN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	STRN3	RGD	RGD:621827
Canis familiaris	STRN3	VGNC	VGNC:46946
Felis catus	STRN3	VGNC	VGNC:80830
Mus musculus	STRN3	MGD	MGI:2151064
Bos taurus	STRN3	VGNC	VGNC:35425
Macaca mulatta	STRN3	VGNC	VGNC:78127

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