STRN - striatin Gene

Homo sapiens

Also known as SG2NA; STRN1; PPP2R6A

Gene ID: 6801 | Gene type: protein coding

About STRN

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:36,837,698-36,966,536 (from NCBI)

This gene has 3 transcripts (splice variants), 271 orthologues, 2 paralogues and is associated with 73 phenotypes. Ubiquitous expression in esophagus (RPKM 6.7), brain (RPKM 5.1) and 25 other tissues.

Summary

Enables armadillo repeat domain binding activity; Estrogen Receptor binding activity; and protein Phosphatase 2A binding activity. Involved in Wnt signaling pathway and negative regulation of cell population proliferation. Located in bicellular tight junction. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2022]

STRN Products(1)

mRNA	Protein	Name
NM_003162.4	NP_003153.2	striatin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables armadillo repeat domain binding	IPI IPI: Inferred from physical interaction	18502210	GOA
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	15569929	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17540176	GOA
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	18782753	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18782753	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18502210	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18502210	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	18782753	GOA
located in bicellular tight junction	IDA IDA: Inferred from direct assay	18502210	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STRN Protein Structure

Striatin

WD40

0
200
400
600
780 a.a.

Protein Preferred Names

Protein Names

striatin

protein phosphatase 2 regulatory subunit B'''alpha

STRN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STRN	O43815	STRN3	Homo sapiens	Q13033	Anti Tag CoIP	18782753
Intra	STRN	O43815	STRN3	Homo sapiens	Q13033	Anti Tag CoIP	33961781
Intra	STRN	O43815	STRN3	Homo sapiens	Q13033	Anti Tag CoIP	26496610
Intra	STRN	O43815	STRN3	Homo sapiens	Q13033	Anti Bait CoIP	18782753
Intra	STRN	O43815	STRN3	Homo sapiens	Q13033	Anti Tag CoIP	24366813
Intra	STRN	O43815	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	24366813
Intra	STRN	O43815	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	26496610
Intra	STRN	O43815	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	33961781
Intra	STRN	O43815	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	18782753
Intra	STRN	O43815	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	33961781
Intra	STRN	O43815	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	26496610
Intra	STRN	O43815	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	18782753
Intra	STRN	O43815	TNKS2	Homo sapiens	Q9H2K2	FPS	22153077
Intra	STRN	O43815	STK25	Homo sapiens	O00506	Anti Tag CoIP	18782753
Intra	STRN	O43815	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	33961781
Intra	STRN	O43815	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	18782753
Intra	STRN	O43815	MOB4	Homo sapiens	Q9Y3A3	Anti Tag CoIP	24366813
Intra	STRN	O43815	MOB4	Homo sapiens	Q9Y3A3	Anti Tag CoIP	18782753
Intra	STRN	O43815	MOB4	Homo sapiens	Q9Y3A3	Anti Tag CoIP	33961781
Intra	STRN	O43815	MOB4	Homo sapiens	Q9Y3A3	Anti Tag CoIP	26496610
Intra	STRN	O43815	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	25416956
Intra	STRN	O43815	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	25416956
Intra	STRN	O43815	STK24	Homo sapiens	Q9Y6E0	Anti Tag CoIP	18782753
Intra	STRN	O43815	STK24	Homo sapiens	Q9Y6E0	Anti Tag CoIP	33961781
Intra	STRN	O43815	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	26496610
Intra	STRN	O43815	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	18782753
Intra	STRN	O43815	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	33961781
Intra	STRN	O43815	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	24366813
Intra	STRN	O43815	TRAF3IP3	Homo sapiens	Q9Y228	Anti Tag CoIP	18782753

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3	CCM3
Cerebral Cavernous Malformations-3	Cavernous Angiomatous Malformations
Cavernous Hemangioma Of The Brain	Cerebral Capillary Malformations
Cerebral Cavernoma	Familial Cavernous Angioma
Cerebral Cavernous Malformations, Type 3

Metanephric Adenoma

Renal Adenoma

Renal Cell Adenoma

Peritoneal Mesothelioma

Malignant Mesothelioma Of Peritoneum	Advanced Malignant Mesothelioma Of Peritoneum
Advanced Malignant Peritoneal Mesothelioma	Advanced Peritoneal Malignant Mesothelioma

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma	Anaplastic Thyroid Cancer
Thyroid Cancer, Anaplastic	Thyroid Carcinoma, Anaplastic
Thyroid Carcinoma Anaplastic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13966	STRN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13967	STRN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13968	STRN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STRN	VGNC	VGNC:78039
Rattus norvegicus	STRN	RGD	RGD:3782
Bos taurus	STRN	VGNC	VGNC:35424
Canis familiaris	STRN	VGNC	VGNC:46945
Mus musculus	STRN	MGD	MGI:1333757
Felis catus	STRN	VGNC	VGNC:81230

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