NRBF2 - nuclear receptor binding factor 2 Gene

Homo sapiens

Also known as COPR; COPR1; COPR2; NRBF-2

Gene ID: 29982 | Gene type: protein coding

About NRBF2

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:63,133,328-63,155,024 (from NCBI)

This gene has 2 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in appendix (RPKM 10.9), placenta (RPKM 10.7) and 25 other tissues.

Summary

Involved in Autophagy. Located in cytoplasm. Colocalizes with phosphatidylinositol 3-kinase complex, class III. [provided by Alliance of Genome Resources, Apr 2022]

NRBF2 Products(2)

mRNA	Protein	Name
NM_001282405.2	NP_001269334.1	nuclear receptor-binding factor 2 isoform 2
NM_030759.5	NP_110386.2	nuclear receptor-binding factor 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20562859	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagy	IMP IMP: Inferred from mutant phenotype	24785657	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of phosphatidylinositol 3-kinase complex, class III	IDA IDA: Inferred from direct assay	24785657	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRBF2 Protein Structure

NRBF2

0
100
200
287 a.a.

Protein Preferred Names

Protein Names

nuclear receptor-binding factor 2

comodulator of PPAR and RXR 1

NRBF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NRBF2	Q96F24	PIK3R4	Homo sapiens	Q99570	Pull Down	24785657
Intra	NRBF2	Q96F24	PIK3R4	Homo sapiens	Q99570	Anti Tag CoIP	24849286
Intra	NRBF2	Q96F24	PIK3R4	Homo sapiens	Q99570	Anti Bait CoIP	24785657
Intra	NRBF2	Q96F24	PIK3R4	Homo sapiens	Q99570	Anti Tag CoIP	33961781
Intra	NRBF2	Q96F24	PIK3R4	Homo sapiens	Q99570	Anti Tag CoIP	28514442
Intra	NRBF2	Q96F24	PIK3R4	Homo sapiens	Q99570	Validated Y2H	32296183
Intra	NRBF2	Q96F24	PIK3R4	Homo sapiens	Q99570	Anti Tag CoIP	24785657
Intra	NRBF2	Q96F24	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	24785657
Intra	NRBF2	Q96F24	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	28514442
Intra	NRBF2	Q96F24	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	24849286
Intra	NRBF2	Q96F24	PIK3C3	Homo sapiens	Q8NEB9	Anti Bait CoIP	24785657
Intra	NRBF2	Q96F24	PIK3C3	Homo sapiens	Q8NEB9	Pull Down	24785657
Intra	NRBF2	Q96F24	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	33961781
Intra	NRBF2	Q96F24	CDC23	Homo sapiens	Q9UJX2	Validated Y2H	32296183
Intra	NRBF2	Q96F24	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	25416956
Intra	NRBF2	Q96F24	C1orf216	Homo sapiens	Q8TAB5	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NRBF2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76523	NRBF2 Protein, Human (sf9, His-GST)	Q96F24-1 (M1-N287)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09561	NRBF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NRBF2	VGNC	VGNC:32254
Canis familiaris	NRBF2	VGNC	VGNC:43960
Mus musculus	NRBF2	MGD	MGI:1354950
Macaca mulatta	NRBF2	VGNC	VGNC:103839
Rattus norvegicus	NRBF2	RGD	RGD:61937
Others	NRBF2	NCBI

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