2. Gene
  3. BAZ2B - bromodomain adjacent to zinc finger domain 2B Gene

BAZ2B - bromodomain adjacent to zinc finger domain 2B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as WALp4

Gene ID: 29994 | Gene type: protein coding

About BAZ2B

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:159,315,312-159,712,442 (from NCBI)

This gene has 17 transcripts (splice variants), 313 orthologues and 11 paralogues. Ubiquitous expression in testis (RPKM 7.8), thyroid (RPKM 5.2) and 25 other tissues.

Summary

This gene belongs to the bromodomain gene family. Members of this gene family encode proteins that are integral components of chromatin remodeling complexes. The encoded protein showed strong preference for the activating H3K14Ac MARK in a histone peptide screen, suggesting a potential role in transcriptional activation. This gene may be associated with susceptibility to sudden cardiac death (SCD). [provided by RefSeq, Aug 2016]

BAZ2B Products(4)

mRNA Protein Name
NM_001289975.1 NP_001276904.1 bromodomain adjacent to zinc finger domain protein 2B isoform b
NM_001329857.2 NP_001316786.1 bromodomain adjacent to zinc finger domain protein 2B isoform c
NM_001329858.2 NP_001316787.1 bromodomain adjacent to zinc finger domain protein 2B isoform d
NM_013450.4 NP_038478.2 bromodomain adjacent to zinc finger domain protein 2B isoform a
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10662543 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
25593309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAZ2B Protein Structure

MBD

MBD: Methyl-CpG binding domain (741 - 811)

DDT

DDT: DDT domain (1088 - 1149)

PHD

PHD: PHD-finger (1933 - 1980)

Bromodomain

Bromodomain: Bromodomain (2069 - 2147)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2168 a.a.
Protein Preferred Names Protein Names

bromodomain adjacent to zinc finger domain protein 2B

BAZ2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BAZ2B Q9UIF8 CTBP2 Homo sapiens P56545-3
Y2H Prey Pooling
32296183
Intra
BAZ2B Q9UIF8 CTBP2 Homo sapiens P56545-3
Validated Y2H
32296183
Intra
BAZ2B Q9UIF8 CTBP2 Homo sapiens P56545-3
Y2H Array
32296183
Intra
BAZ2B Q9UIF8 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
BAZ2B Q9UIF8 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
BAZ2B Q9UIF8 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
BAZ2B Q9UIF8 SEPTIN2 Homo sapiens Q15019-3
Y2H Prey Pooling
32296183
Intra
BAZ2B Q9UIF8 SEPTIN2 Homo sapiens Q15019-3
Y2H Array
32296183
Intra
BAZ2B Q9UIF8 SEPTIN2 Homo sapiens Q15019-3
Validated Y2H
32296183
Intra
BAZ2B Q9UIF8 RASGEF1B Homo sapiens Q0VAM2-3
Y2H Array
32296183
Intra
BAZ2B Q9UIF8 RASGEF1B Homo sapiens Q0VAM2-3
Y2H Prey Pooling
32296183
Intra
BAZ2B Q9UIF8 RASGEF1B Homo sapiens Q0VAM2-3
Validated Y2H
32296183
Intra
BAZ2B Q9UIF8 BIVM Homo sapiens Q86UB2
Y2H Array
32296183
Intra
BAZ2B Q9UIF8 BIVM Homo sapiens Q86UB2
Validated Y2H
32296183
Intra
BAZ2B Q9UIF8 BIVM Homo sapiens Q86UB2
Y2H Prey Pooling
32296183
Intra
BAZ2B Q9UIF8 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
32296183
Intra
BAZ2B Q9UIF8 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
32296183
Intra
BAZ2B Q9UIF8 HMBOX1 Homo sapiens Q6NT76
Y2H Array
32296183
Intra
BAZ2B Q9UIF8 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
BAZ2B Q9UIF8 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra
BAZ2B Q9UIF8 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
BAZ2B Q9UIF8 APIP Homo sapiens Q96GX9
Y2H Array
32296183
Intra
BAZ2B Q9UIF8 APIP Homo sapiens Q96GX9
Y2H Prey Pooling
32296183
Intra
BAZ2B Q9UIF8 APIP Homo sapiens Q96GX9
Validated Y2H
32296183
Intra
BAZ2B Q9UIF8 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
BAZ2B Q9UIF8 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
BAZ2B Q9UIF8 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
BAZ2B Q9UIF8 HSF2BP Homo sapiens O75031
Validated Y2H
32296183
Intra
BAZ2B Q9UIF8 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
BAZ2B Q9UIF8 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
BAZ2B Q9UIF8 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
BAZ2B Q9UIF8 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
BAZ2B Q9UIF8 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
BAZ2B Q9UIF8 FXR2 Homo sapiens P51116
Y2H Array
32296183
Intra
BAZ2B Q9UIF8 FXR2 Homo sapiens P51116
Validated Y2H
32296183
Intra
BAZ2B Q9UIF8 FXR2 Homo sapiens P51116
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Splenic Flexure Cancer

Ca Splenic Flexure - Colon

Malignant Neoplasm Of Splenic Flexure

Malignant Tumor Of Splenic Flexure

Malignant Neoplasm Of Splenic Flexure Of Colon
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15658 GSK2801 99.95% Unkown
HY-19336 BAZ2-ICR Inhibitor 99.95% Unkown
HY-107477 GSK8573 99.05% Unkown
HY-RS01380 BAZ2B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BAZ2B MGD MGI:2442782
Bos taurus BAZ2B VGNC VGNC:55328
Rattus norvegicus BAZ2B RGD RGD:1309801
Canis familiaris BAZ2B VGNC VGNC:53090