BAZ2B - bromodomain adjacent to zinc finger domain 2B Gene

Homo sapiens

Also known as WALp4

Gene ID: 29994 | Gene type: protein coding

About BAZ2B

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:159,315,312-159,712,442 (from NCBI)

This gene has 17 transcripts (splice variants), 313 orthologues and 11 paralogues. Ubiquitous expression in testis (RPKM 7.8), thyroid (RPKM 5.2) and 25 other tissues.

Summary

This gene belongs to the bromodomain gene family. Members of this gene family encode proteins that are integral components of chromatin remodeling complexes. The encoded protein showed strong preference for the activating H3K14Ac mark in a histone peptide screen, suggesting a potential role in transcriptional activation. This gene may be associated with susceptibility to sudden cardiac death (SCD). [provided by RefSeq, Aug 2016]

BAZ2B Products(4)

mRNA	Protein	Name
NM_001289975.1	NP_001276904.1	bromodomain adjacent to zinc finger domain protein 2B isoform b
NM_001329857.2	NP_001316786.1	bromodomain adjacent to zinc finger domain protein 2B isoform c
NM_001329858.2	NP_001316787.1	bromodomain adjacent to zinc finger domain protein 2B isoform d
NM_013450.4	NP_038478.2	bromodomain adjacent to zinc finger domain protein 2B isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10662543	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	25593309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAZ2B Protein Structure

MBD

DDT

PHD

Bromodomain

0
400
800
1200
1600
2000
2168 a.a.

Protein Preferred Names

Protein Names

bromodomain adjacent to zinc finger domain protein 2B

Related Diseases

Diseases

Alias

Splenic Flexure Cancer

Ca Splenic Flexure - Colon	Malignant Neoplasm Of Splenic Flexure
Malignant Tumor Of Splenic Flexure	Malignant Neoplasm Of Splenic Flexure Of Colon

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15658	GSK2801		99.95%	Unkown
HY-19336	BAZ2-ICR	Inhibitor	99.95%	Unkown
HY-107477	GSK8573		99.05%	Unkown
HY-RS01380	BAZ2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BAZ2B	MGD	MGI:2442782
Bos taurus	BAZ2B	VGNC	VGNC:55328
Rattus norvegicus	BAZ2B	RGD	RGD:1309801
Canis familiaris	BAZ2B	VGNC	VGNC:53090

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