ERO1A - endoplasmic reticulum oxidoreductase 1 alpha Gene

Homo sapiens

Also known as ERO1L; ERO1-L; ERO1LA; Ero1alpha; ERO1-alpha; ERO1-L-alpha

Gene ID: 30001 | Gene type: protein coding

About ERO1A

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:52,639,915-52,695,558 (from NCBI)

This gene has 11 transcripts (splice variants), 197 orthologues and 1 paralogue. Broad expression in esophagus (RPKM 69.5), placenta (RPKM 19.1) and 21 other tissues.

Summary

Enables oxidoreductase activity. Involved in chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

ERO1A Products(14)

mRNA	Protein	Name
NM_001382464.1	NP_001369393.1	ERO1-like protein alpha isoform 1 precursor
NM_001382465.1	NP_001369394.1	ERO1-like protein alpha isoform 3 precursor
NM_001382466.1	NP_001369395.1	ERO1-like protein alpha isoform 4 precursor
NM_001382467.1	NP_001369396.1	ERO1-like protein alpha isoform 5 precursor
NM_001382468.1	NP_001369397.1	ERO1-like protein alpha isoform 6 precursor
NM_001382469.1	NP_001369398.1	ERO1-like protein alpha isoform 7 precursor
NM_001382470.1	NP_001369399.1	ERO1-like protein alpha isoform 8 precursor
NM_001382471.1	NP_001369400.1	ERO1-like protein alpha isoform 9 precursor
NM_001382472.1	NP_001369401.1	ERO1-like protein alpha isoform 10 precursor
NM_001382473.1	NP_001369402.1	ERO1-like protein alpha isoform 11 precursor
NM_001382474.1	NP_001369403.1	ERO1-like protein alpha isoform 12 precursor
NM_001382475.1	NP_001369404.1	ERO1-like protein alpha isoform 13 precursor
NM_001382476.1	NP_001369405.1	ERO1-like protein alpha isoform 14 precursor
NM_014584.3	NP_055399.1	ERO1-like protein alpha isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables oxidoreductase activity	IDA IDA: Inferred from direct assay	11707400	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17170699	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell redox homeostasis	IMP IMP: Inferred from mutant phenotype	29858230	GOA
involved in chaperone cofactor-dependent protein refolding	IDA IDA: Inferred from direct assay	11707400	GOA
involved in protein folding	IMP IMP: Inferred from mutant phenotype	29858230	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi lumen	IDA IDA: Inferred from direct assay	29858230	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	10671517	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	29858230	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERO1A Protein Structure

ERO1

0
100
200
300
400
468 a.a.

Protein Preferred Names

Protein Names

ERO1-like protein alpha

endoplasmic oxidoreductin-1-like protein

ERO1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ERO1A	Q96HE7	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	32296183
Intra	ERO1A	Q96HE7	LHX4	Homo sapiens	Q969G2	Y2H Array	32296183
Intra	ERO1A	Q96HE7	P4HB	Homo sapiens	P07237	Anti Tag CoIP	20802462
Intra	ERO1A	Q96HE7	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956
Intra	ERO1A	Q96HE7	PDIA3	Homo sapiens	P30101	Anti Tag CoIP	20802462
Intra	ERO1A	Q96HE7	PDIA3	Homo sapiens	P30101	Anti Tag CoIP	17170699

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ERO1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70893	ERO1L Protein, Human (HEK293, His)	Q96HE7 (E24-H468)	≥95%

Related Diseases

Diseases

Alias

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Hypoascorbemia

Scurvy	Ascorbic Acid Deficiency
Vitamin C Deficiency	Vitamin C, Inability To Synthesize
Deficiency Of Vitamin C	Scorbutus
Vitamin C

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04511	ERO1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ERO1A	VGNC	VGNC:72266
Mus musculus	ERO1A	MGD	MGI:1354385
Bos taurus	ERO1A	VGNC	VGNC:28594
Canis familiaris	ERO1A	VGNC	VGNC:40466
Rattus norvegicus	ERO1A	RGD	RGD:621713
Felis catus	ERO1A	VGNC	VGNC:61954

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