PDIA3 - protein disulfide isomerase family A member 3 Gene

Homo sapiens

Also known as P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n

Gene ID: 2923 | Gene type: protein coding

About PDIA3

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,746,438-43,773,278 (from NCBI)

This gene has 33 transcripts (splice variants), 222 orthologues and 13 paralogues. Ubiquitous expression in thyroid (RPKM 333.0), prostate (RPKM 175.9) and 25 other tissues.

Summary

This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]

PDIA3 Products(2)

mRNA	Protein	Name
NM_005313.5	NP_005304.3	protein disulfide-isomerase A3 precursor
NM_005313.5	NP_005304.3	protein disulfide-isomerase A3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16905107	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15896298	GOA
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	16677074	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptide antigen assembly with MHC class I protein complex	IDA IDA: Inferred from direct assay	17603487	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MHC class I peptide loading complex	IDA IDA: Inferred from direct assay	17947644	GOA
part of Tapasin-ERp57 complex	IPI IPI: Inferred from physical interaction	19119025	GOA
located in cell surface	IDA IDA: Inferred from direct assay	19995400	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23826168	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	19995400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDIA3 Protein Structure

Thioredoxin

Thioredoxin_6

Thioredoxin

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

protein disulfide-isomerase A3

58 kDa glucose-regulated protein	58 kDa microsomal protein
ER protein 57	ER protein 60
disulfide isomerase ER-60	endoplasmic reticulum P58
endoplasmic reticulum resident protein 57	endoplasmic reticulum resident protein 60
epididymis secretory protein Li 269	epididymis secretory sperm binding protein Li 93n
glucose regulated protein, 58kDa	phospholipase C-alpha
protein disulfide isomerase-associated 3

Related Diseases

Diseases

Alias

Granulomatous Orchitis

Non-Specific Granulomatous Orchitis

Macular Degeneration, Age-Related, 15

Age Related Macular Degeneration 15	ARMD15
Macular Degeneration, Age-Related, 15, Susceptibility To	Macular Degeneration, Age-Related, Type 15

Creutzfeldt-Jakob Disease

Variant Creutzfeldt-Jakob Disease	CJD
Bovine Spongiform Encephalopathy	Vcjd
Inherited Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease, Familial
Creutzfeldt Jakob Disease	Creutzfeldt-Jacob Disease
Creutzfeldt Jacob Disease	Sporadic Creutzfeldt-Jakob Disease
Encephalopathy, Bovine Spongiform	Creutzfeldt-Jakob Disease, Variant, Resistance To
Creutzfeldt-Jakob Disease, Variant	Creutzfeldt Jacob Syndrome
Jakob-Creutzfeldt Disease	Subacute Spongiform Encephalopathy
Transmissible Virus Dementia	New Variant Of Cjd
Nv-Cjd	Variant Cjd
Variant Creutzfeldt-Jacob Disease	Sporadic Cjd
Inherited Cjd	Acquired Creutzfeldt-Jakob Disease
Variant Mcj	Encephalopathy Bovine Spongiform
Familial Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Syndrome
New Variant Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease, Sporadic
Acquired Cjd	Scjd - [Sporadic Creutzfeldt-Jakob Disease]
Idiopathic Creutzfeldt-Jakob Disease	Creutzfeld-Jakob Disease Nos
Vcjd - [Variant Creutzfeldt-Jakob Disease]

Prion Disease

Spongiform Encephalopathy	Transmissible Spongiform Encephalopathies
Prion Diseases	Prion Disease Pathway
Transmissible Spongiform Encephalopathy	Prion Induced Disorder
Prion Protein Disease	Inherited Human Transmissible Spongiform Encephalopathies
Prion Protein Diseases	Prion-Associated Disorders
Prion-Induced Disorders	Transmissible Dementias
Tses	Human Prion Disease
Tse	Encephalopathy, Transmissible Spongiform
Prion Disease, Susceptibility To	Spongiform Encephalopathies
Human Transmissible Spongiform Encephalopathies, Inherited

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0177	Diosgenin	Inhibitor	≥98.0%	Unkown
HY-100432	LOC14		≥98.0%	Unkown
HY-122895	E64FC26		98.10%	Unkown
HY-122895A	(E/Z)-E64FC26		98.09%	Unkown
HY-151286	Antitumor agent-73	Inhibitor	/	Unkown
HY-RS10266	PDIA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10267	Pdia3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10268	Pdia3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PDIA3	VGNC	VGNC:67483
Mus musculus	PDIA3	MGD	MGI:95834
Bos taurus	PDIA3	VGNC	VGNC:32697
Canis familiaris	PDIA3	VGNC	VGNC:103695
Rattus norvegicus	PDIA3	RGD	RGD:68430
Macaca mulatta	PDIA3	VGNC	VGNC:75905

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