2. Gene
  3. HAGH - hydroxyacylglutathione hydrolase Gene

HAGH - hydroxyacylglutathione hydrolase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GLO2; GLX2; GLXII; HAGH1

Gene ID: 3029 | Gene type: protein coding

About HAGH

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,807,629-1,827,194 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 47.0), liver (RPKM 45.0) and 25 other tissues.

Summary

The Enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

HAGH Products(5)

mRNA Protein Name
NM_001040427.2 NP_001035517.1 hydroxyacylglutathione hydrolase, mitochondrial isoform 2
NM_001286249.2 NP_001273178.1 hydroxyacylglutathione hydrolase, mitochondrial isoform 3 precursor
NM_001363912.1 NP_001350841.1 hydroxyacylglutathione hydrolase, mitochondrial isoform 4 precursor
NM_001363914.1 NP_001350843.1 hydroxyacylglutathione hydrolase, mitochondrial isoform 5
NM_005326.6 NP_005317.2 hydroxyacylglutathione hydrolase, mitochondrial isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables hydroxyacylglutathione hydrolase activity IDA
IDA: Inferred from direct assay
8550579 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence Reference Source
involved in glutathione biosynthetic process IDA
IDA: Inferred from direct assay
8550579 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15117945 GOA
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
15117945 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAGH Protein Structure

Lactamase_B

Lactamase_B: Metallo-beta-lactamase superfamily (57 - 221)

  • 0
  • 100
  • 200
  • 308 a.a.
Protein Preferred Names Protein Names

hydroxyacylglutathione hydrolase, mitochondrial

glyoxalase II

HAGH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HAGH Q16775 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
HAGH Q16775 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HAGH Proteins

Cat. No. Product Name Accession Purity
HY-P71690 GLO2/Glyoxalase II Protein, Human (GST) Q16775-1 (K50-D308) ≥95%

Related Diseases

Diseases Alias
Hydroxyacyl Glutathione Hydrolase Deficiency

Glyoxalase Ii Deficiency
Triosephosphate Isomerase Deficiency

TPID

Triose Phosphate-Isomerase Deficiency

Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency

Tpi Deficiency

Triose Phosphate Isomerase Deficiency

Deficiency Of Phosphotriose Isomerase

Hereditary Nonspherocytic Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency
Yaws

Frambesia

Frambesia Tropica

Bouba

Frambosie

Polypapilloma Tropicum

Thymosis

Endemic Treponematoses

Treponema Pertenue Infection

Pian

Framboesia

Framboesia Tropica

Castellani

Infection By Treponema Pertenue

Parangi

Framboesioma

Chancre Of Yaws

Primary Framboesia

Initial Lesions Of Yaws

Mother Yaw

Initial Framboesia
Encephalopathy, Ethylmalonic

Ethylmalonic Encephalopathy

EE

Epema Syndrome

Encephalopathy, Petechiae, And Ethylmalonic Aciduria

Ethe1 Deficiency

Eme

Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05992 HAGH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HAGH VGNC VGNC:41585
Mus musculus HAGH MGD MGI:95745
Bos taurus HAGH VGNC VGNC:29742
Felis catus HAGH VGNC VGNC:67533
Rattus norvegicus HAGH RGD RGD:2779
Macaca mulatta HAGH VGNC VGNC:73343
Others HAGH NCBI