HARS1 - histidyl-tRNA synthetase 1 Gene

Homo sapiens (human)

Also known as HRS; HARS; CMT2W; USH3B

Gene ID: 3035 | Gene type: protein coding

About HARS1

Summary

Aminoacyl-tRNA synthetases are a class of Enzymes that charge tRNAs with their cognate Amino acids. The protein encoded by this gene is a cytoplasmic Enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The Enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

HARS1 Products(1)

mRNA	Protein	Name
NM_001289092.2	NP_001276021.1	histidine--tRNA ligase, cytoplasmic isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	29235198	GOA
enables histidine-tRNA ligase activity	IDA IDA: Inferred from direct assay	29235198	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22958643	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	29235198	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in histidyl-tRNA aminoacylation	IDA IDA: Inferred from direct assay	29235198	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21464306	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

histidine--tRNA ligase, cytoplasmic

HisRS	Jo-1 antigen
histidine translase

HARS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HARS1	P12081	HARS1	Homo sapiens	P12081	X-Ray Diffraction	22958643
Intra	HARS1	P12081	HARS1	Homo sapiens	P12081	GMS	22958643
Intra	HARS1	P12081	TNIK	Homo sapiens	Q9UKE5	Y2H	17043677
Intra	HARS1	P12081	MTNR1B	Homo sapiens	P49286	Y2H	26514267

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HARS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73933	HARS/HisRS Protein, Human (sf9, His)	P12081-1/NP_002100.2 (A2-C509)	≥95%

HARS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81278	HARS Antibody (YA977)	WB	Human, Mouse, Monkey
HY-P81278B	HARS Antibody (YA978)	WB, IP	Human

Related Agents

Pre-clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990782	Efzofitimod		/	Unkown

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