2. Gene
  3. HARS1 - histidyl-tRNA synthetase 1 Gene

HARS1 - histidyl-tRNA synthetase 1 Gene

  • Gene
  • Protein
  • Agent
Homo sapiens (human)

Also known as HRS; HARS; CMT2W; USH3B

Gene ID: 3035 | Gene type: protein coding

About HARS1

Summary

Aminoacyl-tRNA synthetases are a class of Enzymes that charge tRNAs with their cognate Amino acids. The protein encoded by this gene is a cytoplasmic Enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The Enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

HARS1 Products(1)

mRNA Protein Name
NM_001289092.2 NP_001276021.1 histidine--tRNA ligase, cytoplasmic isoform 5
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
29235198 GOA
enables histidine-tRNA ligase activity IDA
IDA: Inferred from direct assay
29235198 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
22958643 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
29235198 GOA
Biological Process GO Annotation Evidence Reference Source
involved in histidyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
29235198 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21464306 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histidine--tRNA ligase, cytoplasmic

HisRS

Jo-1 antigen

histidine translase

Recombinant HARS1 Proteins

Cat. No. Product Name Accession Purity
HY-P73933 HARS/HisRS Protein, Human (sf9, His) P12081-1/NP_002100.2 (A2-C509) ≥95%

Related Agents

Pre-clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990782 Efzofitimod / Unkown