TNIK - TRAF2 and NCK interacting kinase Gene

Homo sapiens

Also known as MRT54

Gene ID: 23043 | Gene type: protein coding

About TNIK

Cytogenetic location: 3q26.2-q26.31 Genomic coordinates (GRCh38): 3:171,058,414-171,460,408 (from NCBI)

This gene has 15 transcripts (splice variants), 268 orthologues, 35 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 10.5), small intestine (RPKM 7.1) and 20 other tissues.

Summary

Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

TNIK Products(9)

mRNA	Protein	Name
NM_001161564.3	NP_001155036.1	TRAF2 and NCK-interacting protein kinase isoform 6
NM_001161565.3	NP_001155037.1	TRAF2 and NCK-interacting protein kinase isoform 7
NM_001161560.3	NP_001155032.1	TRAF2 and NCK-interacting protein kinase isoform 2
NM_001161566.3	NP_001155038.1	TRAF2 and NCK-interacting protein kinase isoform 8
NM_001161561.3	NP_001155033.1	TRAF2 and NCK-interacting protein kinase isoform 3
NM_001161563.3	NP_001155035.1	TRAF2 and NCK-interacting protein kinase isoform 5
NM_015028.4	NP_055843.1	TRAF2 and NCK-interacting protein kinase isoform 1
NR_027767.2
NM_001161562.3	NP_001155034.1	TRAF2 and NCK-interacting protein kinase isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10521462	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	22797597	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10521462	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	15342639	GOA
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	10521462	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10521462	GOA
involved in microvillus assembly	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	15342639	GOA
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	10521462	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10521462	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10521462	GOA
involved in regulation of dendrite morphogenesis	IDA IDA: Inferred from direct assay	20159449	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	22797597	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15342639	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	15342639	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19816403	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNIK Protein Structure

Pkinase

CNH

0
300
600
900
1200
1360 a.a.

Protein Preferred Names

Protein Names

TRAF2 and NCK-interacting protein kinase

Related Diseases

Diseases

Alias

Scoliosis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Intellectual Developmental Disorder, Autosomal Recessive 54

MRT54

Mental Retardation, Autosomal Recessive 54

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100830	NCB-0846	Inhibitor	99.61%	Unkown
HY-111754	DMX-5804	Inhibitor	99.83%	Unkown
HY-10371	Pim1/AKK1-IN-1	Inhibitor	98.20%	Unkown
HY-124745	KY-05009		99.24%	Unkown
HY-145293	TNIK-IN-3	Inhibitor	99.88%	Unkown
HY-160623	INS018 055	Inhibitor	99.38%	Unkown
HY-124762	TNIK-IN-1		98.86%	Unkown
HY-156816	ON 108600	Inhibitor	99.73%	Unkown
HY-143437	TNIK-IN-5	Inhibitor	99.75%	Unkown
HY-N3127	Orobol	Inhibitor	99.28%	Unkown
HY-156817	TNIK-IN-6		96.92%	Unkown
HY-156818	TNIK-IN-7		99.90%	Unkown
HY-156502	TINK-IN-1	Inhibitor	98.02%	Unkown
HY-162314	TNIK-IN-8	Inhibitor	/	Unkown
HY-143436	TNIK-IN-4	Inhibitor	/	Unkown
HY-145292	TNIK-IN-2		99.68%	Unkown
HY-156523	TNIK&MAP4K4-IN-1		/	Unkown
HY-163478	TNIK-IN-9	Inhibitor	/	Unkown
HY-RS14831	TNIK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14832	Tnik Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14833	Tnik Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TNIK	VGNC	VGNC:36179
Macaca mulatta	TNIK	VGNC	VGNC:81595
Felis catus	TNIK	VGNC	VGNC:97666
Mus musculus	TNIK	MGD	MGI:1916264
Rattus norvegicus	TNIK	RGD	RGD:1561817
Canis familiaris	TNIK	VGNC	VGNC:47675
Others	TNIK	NCBI

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