NT5C - 5', 3'-nucleotidase, cytosolic Gene

Homo sapiens

Also known as DNT; cdN; DNT1; P5N2; PN-I; HEL74; PN-II; UMPH2; dNT-1

Gene ID: 30833 | Gene type: protein coding

About NT5C

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,130,228-75,131,742 (from NCBI)

This gene has 14 transcripts (splice variants), 115 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 12.8), spleen (RPKM 11.1) and 25 other tissues.

Summary

This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this Enzyme is unique in its preference for 5'-dNTP. It may be one of the Enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

NT5C Products(2)

mRNA	Protein	Name
NM_001252377.2	NP_001239306.1	5'(3')-deoxyribonucleotidase, cytosolic type isoform 2
NM_014595.3	NP_055410.1	5'(3')-deoxyribonucleotidase, cytosolic type isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	31515488	GOA
enables nucleotidase activity	IDA IDA: Inferred from direct assay	10681516	GOA
enables pyrimidine nucleotide binding	IDA IDA: Inferred from direct assay	10681516	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in dephosphorylation	IDA IDA: Inferred from direct assay	10681516	GOA
involved in pyrimidine deoxyribonucleotide catabolic process	IDA IDA: Inferred from direct assay	10681516	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10681516	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10681516	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NT5C Protein Structure

NT5C

0
100
201 a.a.

Protein Preferred Names

Protein Names

5'(3')-deoxyribonucleotidase, cytosolic type

5' nucleotidase, deoxy (pyrimidine), cytosolic type C

NT5C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NT5C	Q8TCD5	RAP1GDS1	Homo sapiens	P52306	Anti Tag CoIP	33961781
Intra	NT5C	Q8TCD5	NT5C	Homo sapiens	Q8TCD5	Validated Y2H	32296183
Intra	NT5C	Q8TCD5	RAP1GDS1	Homo sapiens	P52306	Anti Tag CoIP	28514442
Intra	NT5C	Q8TCD5	NT5C	Homo sapiens	Q8TCD5	Y2H Array	32296183
Intra	NT5C	Q8TCD5	NT5C	Homo sapiens	Q8TCD5	Y2H Array	31515488
Intra	NT5C	Q8TCD5	NT5C	Homo sapiens	Q8TCD5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Trichostrongylosis

Trichostrongyliasis	Infection By Trichostrongylus
Infection By Trichostrongylus Species	Trichostrongylus Infestation

Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive	Autosomal Recessive Robinow Syndrome
Covesdem Syndrome	RRS1
Costovertebral Segmentation Defect-Mesomelia Syndrome	Rrs
Costovertebral Segmentation Defect With Mesomelia, Formerly	Covesdem Syndrome, Formerly
Costovertebral Segmentation Defect With Mesomelia	Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly	Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly	Robinow, Autosomal Recessive Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09607	NT5C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09608	NT5C1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09609	NT5C2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-167710	CRCD2		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NT5C	VGNC	VGNC:99311
Mus musculus	NT5C	MGD	MGI:1354954
Canis familiaris	NT5C	VGNC	VGNC:43994
Bos taurus	NT5C	VGNC	VGNC:32289
Rattus norvegicus	NT5C	RGD	RGD:2321875
Macaca mulatta	NT5C	VGNC	VGNC:99191
Others	NT5C	NCBI

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