2. Gene
  3. RAP1GDS1 - Rap1 GTPase-GDP dissociation stimulator 1 Gene

RAP1GDS1 - Rap1 GTPase-GDP dissociation stimulator 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GDS1; SmgGDS

Gene ID: 5910 | Gene type: protein coding

About RAP1GDS1

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:98,261,384-98,443,858 (from NCBI)

This gene has 21 transcripts (splice variants), 207 orthologues and is associated with 64 phenotypes. Ubiquitous expression in brain (RPKM 27.0), testis (RPKM 10.3) and 25 other tissues.

Summary

The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]

RAP1GDS1 Products(6)

mRNA Protein Name
NM_001100426.2 NP_001093896.1 rap1 GTPase-GDP dissociation stimulator 1 isoform 1
NM_001100427.2 NP_001093897.1 rap1 GTPase-GDP dissociation stimulator 1 isoform 3
NM_001100428.2 NP_001093898.1 rap1 GTPase-GDP dissociation stimulator 1 isoform 4
NM_001100429.2 NP_001093899.1 rap1 GTPase-GDP dissociation stimulator 1 isoform 5
NM_001100430.2 NP_001093900.1 rap1 GTPase-GDP dissociation stimulator 1 isoform 6
NM_021159.5 NP_066982.3 rap1 GTPase-GDP dissociation stimulator 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
21242305 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20936779 GOA
Biological Process GO Annotation Evidence Reference Source
involved in CAAX-box protein maturation IMP
IMP: Inferred from mutant phenotype
20709748 GOA
involved in negative regulation of endoplasmic reticulum calcium ion concentration IMP
IMP: Inferred from mutant phenotype
24349085 GOA
involved in positive regulation of mitochondrial calcium ion concentration IMP
IMP: Inferred from mutant phenotype
24349085 GOA
involved in protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
12551911 GOA
involved in regulation of mitochondrion organization IMP
IMP: Inferred from mutant phenotype
27716788 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
24349085 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
24349085 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
24349085 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12551911 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAP1GDS1 Protein Structure

Arm

Arm: Armadillo/beta-catenin-like repeat (83 - 117)

Arm

Arm: Armadillo/beta-catenin-like repeat (169 - 210)

Arm

Arm: Armadillo/beta-catenin-like repeat (346 - 389)

Arm

Arm: Armadillo/beta-catenin-like repeat (481 - 518)

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  • 500
  • 607 a.a.
Protein Preferred Names Protein Names

rap1 GTPase-GDP dissociation stimulator 1

RAP1, GTP-GDP dissociation stimulator 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11656 RAP1GDS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RAP1GDS1 VGNC VGNC:76659
Bos taurus RAP1GDS1 VGNC VGNC:33718
Mus musculus RAP1GDS1 MGD MGI:2385189
Rattus norvegicus RAP1GDS1 RGD RGD:1308558
Canis familiaris RAP1GDS1 VGNC VGNC:45343
Felis catus RAP1GDS1 VGNC VGNC:69237