DNTTIP2 - deoxynucleotidyltransferase terminal interacting protein 2 Gene

Homo sapiens

Also known as ERBP; FCF2; TdIF2; HSU15552; LPTS-RP2

Gene ID: 30836 | Gene type: protein coding

About DNTTIP2

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,866,284-93,879,206 (from NCBI)

This gene has 7 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in bone marrow (RPKM 37.4), testis (RPKM 17.8) and 25 other tissues.

Summary

This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the Estrogen Receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010]

DNTTIP2 Products(1)

mRNA	Protein	Name
NM_014597.5	NP_055412.2	deoxynucleotidyltransferase terminal-interacting protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNTTIP2 Protein Structure

Fcf2

0
200
400
600
756 a.a.

Protein Preferred Names

Protein Names

deoxynucleotidyltransferase terminal-interacting protein 2

LPTS-interacting protein 2

DNTTIP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DNTTIP2	Q5QJE6	CAVIN1	Homo sapiens	Q6NZI2	Validated Y2H	32296183
Intra	DNTTIP2	Q5QJE6	CAVIN1	Homo sapiens	Q6NZI2	Y2H Array	32296183
Intra	DNTTIP2	Q5QJE6	CAVIN1	Homo sapiens	Q6NZI2	Y2H Prey Pooling	32296183
Intra	DNTTIP2	Q5QJE6	RNF8	Homo sapiens	O76064	Y2H Prey Pooling	32296183
Intra	DNTTIP2	Q5QJE6	RNF8	Homo sapiens	O76064	Y2H Array	32296183
Intra	DNTTIP2	Q5QJE6	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	DNTTIP2	Q5QJE6	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	DNTTIP2	Q5QJE6	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	DNTTIP2	Q5QJE6	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	DNTTIP2	Q5QJE6	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	DNTTIP2	Q5QJE6	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03918	DNTTIP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DNTTIP2	MGD	MGI:1923173
Canis familiaris	DNTTIP2	VGNC	VGNC:40041
Rattus norvegicus	DNTTIP2	RGD	RGD:6497192
Bos taurus	DNTTIP2	VGNC	VGNC:28152
Felis catus	DNTTIP2	VGNC	VGNC:61567
Macaca mulatta	DNTTIP2	VGNC	VGNC:99896

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