Angptl3 - angiopoietin-like 3 Gene

Mus musculus

Also known as hypl

Gene ID: 30924 | Gene type: protein coding

About Angptl3

Summary

This gene encodes a member of the angiopoietin-like family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may inhibit triglyceride metabolism. Homozygous knockout mice for this gene exhibit reduced plasma lipid concentrations, including reduced plasma triglyceride concentrations, and enhanced activity of Enzymes involved in triglyceride metabolism. [provided by RefSeq, Aug 2015]

Angptl3 Products(1)

mRNA	Protein	Name
NM_013913.4	NP_038941.1	angiopoietin-related protein 3 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	12097324	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in acylglycerol homeostasis	IMP IMP: Inferred from mutant phenotype	17110602	MGI
involved in artery morphogenesis	IMP IMP: Inferred from mutant phenotype	12671033	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	17110602	MGI
involved in negative regulation of phospholipase activity	IMP IMP: Inferred from mutant phenotype	17110602	MGI
involved in phospholipid homeostasis	IMP IMP: Inferred from mutant phenotype	17110602	MGI
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	19542565	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	23918928	MGI
located in cell surface	IDA IDA: Inferred from direct assay	23918928	MGI
located in early endosome	IDA IDA: Inferred from direct assay	23918928	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

angiopoietin-related protein 3

angiopoietin-like protein 3

Recombinant Angptl3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7504	ANGPTL3/Angiopoietin-like 3 Protein, Mouse (HEK293, His)	Q9R182 (S17-T206)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153497A	Vupanorsen sodium	Inhibitor	92.29%	Phase 2
HY-153497	Vupanorsen	Inhibitor	92.29%	Phase 2

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Angptl3	NCBI	NCBI:27329
Macaca fascicularis	Angptl3	NCBI	NCBI:102136264

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