HLA-DPB1 - major histocompatibility complex, class II, DP beta 1 Gene

Homo sapiens

Also known as DPB1; HLA-DP; HLA-DPB; HLA-DP1B

Gene ID: 3115 | Gene type: protein coding

About HLA-DPB1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,075,990-33,089,696 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 69 orthologues, 13 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 88.0), lymph node (RPKM 85.6) and 22 other tissues.

Summary

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting Peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

HLA-DPB1 Products(1)

mRNA	Protein	Name
NM_002121.6	NP_002112.3	HLA class II histocompatibility antigen, DP beta 1 chain precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptide antigen binding	IDA IDA: Inferred from direct assay	20356827	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	32341563	GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA IDA: Inferred from direct assay	32341563	GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP IMP: Inferred from mutant phenotype	20356827	GOA
involved in positive regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	20356827	GOA
involved in positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	20356827	GOA
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	20356827	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MHC class II protein complex	IDA IDA: Inferred from direct assay	20356827	GOA
located in cell surface	IMP IMP: Inferred from mutant phenotype	20356827	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-DPB1 Protein Structure

MHC_II_beta

C1-set

0
100
200
235 a.a.

Protein Preferred Names

Protein Names

HLA class II histocompatibility antigen, DP beta 1 chain

HLA class II histocompatibility antigen, DP(W4) beta chain

Recombinant HLA-DPB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71696	HLA-DPB1 Protein, Human (His)	P04440 (R30-R223)	≥95%

Related Diseases

Diseases

Alias

Chronic Beryllium Disease

Chronic Berylliosis	Berylliosis
Chronic Beryllium Lung Disease	Beryllium Disease Chronic
Beryllium Disease, Chronic, Susceptibility To

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Juvenile Rheumatoid Arthritis

Juvenile Idiopathic Arthritis	Juvenile Chronic Polyarthritis
Monarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Arthritis
Still'S Disease	Systemic Juvenile Rheumatoid Arthritis
Juvenile Chronic Arthritis	Acute Juvenile Rheumatoid Arthritis
Pauciarticular Onset Juvenile Chronic Arthritis	Arthritis, Juvenile Rheumatoid
Jia	Jra
Juvenile Ra	Arthritis Juvenile Rheumatoid
Stills Disease	Juvenile Arthritis
Acute Polyarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Rheumatoid Arthritis
Rheumatoid Arthritis, Systemic Juvenile

Myelitis

Spinal Cord Inflammation Nos	Radiculomyelitis Nos
Myeloradiculitis

Rubella

German Measles	Three Day Measles
Rubella Nos

Neuromyelitis Optica

Devic Disease	Devic Syndrome
Neuromyelitis Optica Spectrum Disorder	Devic'S Disease
Devic'S Syndrome	Devic'S Neuromyelitis Optica
Nmo	Nmo Spectrum Disorder
Neuromyelitis Optica Spectrum Disorders	Devic Neuromyelitis Optica
Optic-Spinal Ms	Opticospinal Ms
Nmosd	Opticospinal Multiple Sclerosis
Devic	Ophthalmoneuromyelitis
Optic Neuromyelitis	Optic Neuroencephalomyelopathy
Nmo - [Neuromyelitis Optica]	Optic Neuritis With Demyelination

Juvenile Dermatitis Herpetiformis

Takayasu Arteritis

Aortic Arch Syndrome	Pulseless Disease
Takayasu'S Arteritis	Idiopathic Aortitis
Young Female Arteritis	Aortic Arch Arteritis
Aortic Arches Defect	Aortic Arch Defects
Takayasu Disease	Aortic Arch Syndromes
Takayasu'S Disease	Ta
Obliterative Aortitis	Aortic Arch Giant-Cell Arteritis
Subclavian-Carotid Obstruction Syndrome	Idiopathic Medial Aortopathy And Arteriopathy
Takayasu Syndrome	Obliterative Brachiocephalic Arteritis Syndrome
Raeder-Harbitz Syndrome	Chronic Subclavian-Carotid Obstruction Syndrome
Giant-Cell Aortitis	Takayasu Aortitis
Nonspecific Aortoarteritis	Sclerosing Aortitis And Arteritis
Martorell 2 Syndrome	Young Female Aortic Arch Arteritis Syndrome

Japanese Encephalitis

Japanese B Encephalitis	Je
Encephalitis Japanese	Encephalitis, Japanese
Russian Autumnal Encephalitis	Je - [Japanese Encephalitis]
Japanese Encephalitis Virus Disease	Jbe - [Japanese B Encephalitis}
B Type Encephalitis

Myasthenia Gravis

MG	Acquired Myasthenia
Autoimmune Myasthenia Gravis	Erb-Goldflam Disease
Mg - [Myasthenia Gravis]	Myasthenia Gravis Nos
Myasthenia

Mumps

Parotitis Due To Mumps Virus	Mumps Nos
Epidemic Parotitis	Infectious Parotitis

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Juvenile Ankylosing Spondylitis

Berylliosis

Beryllium Poisoning	Beryllium Disease
Lung Fibrosis With Berylliosis

Mixed Connective Tissue Disease

Sharp Syndrome	Mctd
Connective Tissue Disease Overlap Syndrome	Mixed Collagen Vascular Disease
Mctd - [Mixed Connective Tissue Disease]

Inflammatory Bowel Disease 18

IBD18

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Apple Allergy

Malus Domestica Fruit Allergy

Byssinosis

Flax-Dressers' Disease	Cotton Mill Fever
Stripper'S Asthma	Monday Morning Fever
Cotton Workers' Lung Disease	Cotton-Dust Asthma
Mill Fever	Lung Fibrosis With Byssinosis
Airway Disease Due To Cotton Dust	Respiratory Tract Disorder Due To Cotton Dust
Strippers' Disease	Flax-Dressers' Disorder
Strippers' Asthma

Tuberculous Epididymitis

Tuberculosis Of Epididymis

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Occupational Asthma

Environmental Induced Asthma

Irritant Asthma

Subacute Lymphocytic Thyroiditis

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Iridocyclitis

Primary Iridocyclitis

West Nile Encephalitis

West-Nile Encephalitis	West Nile Fever
West Nile Fever Encephalitis	West Nile Fever With Encephalitis
West-Nile Fever	Encephalitis, West Nile Fever

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diabetes Mellitus

Diabetes

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06204	HLA-DPB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown