HLA-E - major histocompatibility complex, class I, E Gene

Homo sapiens

Also known as QA1; HLA-6.2

Gene ID: 3133 | Gene type: protein coding

About HLA-E

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,489,509-30,494,194 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 572 orthologues and 22 paralogues. Ubiquitous expression in spleen (RPKM 452.2), lung (RPKM 398.4) and 24 other tissues.

Summary

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of Peptides derived from the leader Peptides of Other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-E Products(1)

mRNA	Protein	Name
NM_005516.6	NP_005507.3	HLA class I histocompatibility antigen, alpha chain E precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MHC class I protein binding	IDA IDA: Inferred from direct assay	9754572	GOA
enables T cell receptor binding	IDA IDA: Inferred from direct assay	16474394	GOA
enables beta-2-microglobulin binding	IDA IDA: Inferred from direct assay	16474394	GOA
enables beta-2-microglobulin binding	IMP IMP: Inferred from mutant phenotype	12411439	GOA
enables natural killer cell lectin-like receptor binding	IPI IPI: Inferred from physical interaction	25631937	GOA
enables peptide antigen binding	IDA IDA: Inferred from direct assay	9427624	GOA
enables peptide antigen binding	IMP IMP: Inferred from mutant phenotype	12411439	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9427624	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	18448674	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CD8-positive, alpha-beta T cell activation	IDA IDA: Inferred from direct assay	25631937	GOA
involved in adaptive immune response	IDA IDA: Inferred from direct assay	25631937	GOA
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	25631937	GOA
involved in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IDA IDA: Inferred from direct assay	9754572	GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class Ib	IDA IDA: Inferred from direct assay	20195504	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	25631937	GOA
involved in natural killer cell tolerance induction	IDA IDA: Inferred from direct assay	9486650	GOA
involved in negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	20195504	GOA
involved in negative regulation of natural killer cell activation	IDA IDA: Inferred from direct assay	37264229	GOA
involved in negative regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	9486650	GOA
involved in positive regulation of CD8-positive, alpha-beta T cell activation	IDA IDA: Inferred from direct assay	28676677	GOA
involved in positive regulation of CD8-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	25631937	GOA
involved in positive regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	20195504	GOA
involved in positive regulation of TRAIL production	IDA IDA: Inferred from direct assay	25631937	GOA
involved in positive regulation of antibody-dependent cellular cytotoxicity	IDA IDA: Inferred from direct assay	30134159	GOA
involved in positive regulation of immunoglobulin production	IDA IDA: Inferred from direct assay	25631937	GOA
involved in positive regulation of interleukin-13 production	IDA IDA: Inferred from direct assay	25631937	GOA
involved in positive regulation of interleukin-4 production	IDA IDA: Inferred from direct assay	25631937	GOA
involved in positive regulation of natural killer cell activation	IDA IDA: Inferred from direct assay	37264229	GOA
involved in positive regulation of natural killer cell cytokine production	IDA IDA: Inferred from direct assay	30134159	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	23335510	GOA
involved in positive regulation of natural killer cell mediated immunity	IDA IDA: Inferred from direct assay	9754572	GOA
involved in positive regulation of natural killer cell proliferation	IDA IDA: Inferred from direct assay	30134159	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	25631937	GOA
involved in protection from natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	9754572	GOA
involved in regulation of natural killer cell mediated immunity	IDA IDA: Inferred from direct assay	18448674	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MHC class I protein complex	IDA IDA: Inferred from direct assay	12411439	GOA
part of MHC class Ib protein complex	IDA IDA: Inferred from direct assay	9427624	GOA
located in cell surface	IDA IDA: Inferred from direct assay	9754572	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9427624	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-E Protein Structure

MHC_I

C1-set

0
100
200
300
358 a.a.

Protein Preferred Names

Protein Names

HLA class I histocompatibility antigen, alpha chain E

MHC class I antigen E

HLA-E Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HLA-E	P13747	HLA-F	Homo sapiens	P30511	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HLA-E Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77758	HLA-E*0103 Complex Protein, Human (HEK293, His-Avi)	P13747 (G22-T302)&P61769 (I21-M119)&VMAPRTLVL	≥95%
HY-P77759	HLA-E*0103 Complex Protein, Human (Biotinylated, HEK293, His-Avi)	P13747 (G22-T302)&P61769 (I21-M119)&VMAPRTLVL	≥95%
HY-P77760	HLA-E*0103 Complex Tetramer Protein, Human (HEK293, His-Avi)	P13747 (G22-T302)&P61769 (I21-M119)&VMAPRTLVL	≥95%
HY-P77761	HLA-E*0103 Complex Tetramer Protein, Human (Biotinylated, HEK293, His-Avi)	P13747 (G22-T302)&P61769 (I21-M119)&VMAPRTLVL	≥95%

HLA-E Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83701	HLA E Antibody (YA3437)	WB, IP, FC	Human

Related Diseases

Diseases

Alias

Choriocarcinoma

Chorioepithelioma

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections

Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy

Nk Cell Deficiency

Parotid Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Parotid Gland

Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency	Mhc Class I Deficiency
Bls, Type I	Bare Lymphocyte Syndrome Type I
Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency	Blsi
Mhc Class 1 Deficiency	Major Histocompatibility Complex Class 1 Deficiency
Bare Lymphocyte Syndrome 1	BLS1
Bls I	Bls Type I
Bl-1	Bare Lymphocyte Syndrome Type 1
Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1	Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens
Bls - [Bare Lymphocyte Syndrome] Nos

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06215	HLA-E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HLA-E	RGD	RGD:1595923

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