MR1 - major histocompatibility complex, class I-related Gene

Homo sapiens

Also known as HLALS

Gene ID: 3140 | Gene type: protein coding

About MR1

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:181,033,387-181,061,938 (from NCBI)

This gene has 12 transcripts (splice variants), 649 orthologues and 22 paralogues. Ubiquitous expression in urinary bladder (RPKM 6.3), thyroid (RPKM 5.6) and 24 other tissues.

Summary

MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]

MR1 Products(9)

mRNA	Protein	Name
NM_001194999.2	NP_001181928.1	major histocompatibility complex class I-related gene protein isoform 2 precursor
NM_001195000.2	NP_001181929.1	major histocompatibility complex class I-related gene protein isoform 3 precursor
NM_001195035.2	NP_001181964.1	major histocompatibility complex class I-related gene protein isoform 4 precursor
NM_001310213.2	NP_001297142.1	major histocompatibility complex class I-related gene protein isoform 5
NM_001385161.1	NP_001372090.1	major histocompatibility complex class I-related gene protein isoform 1 precursor
NM_001385162.1	NP_001372091.1	major histocompatibility complex class I-related gene protein isoform 6 precursor
NM_001385163.1	NP_001372092.1	major histocompatibility complex class I-related gene protein isoform 7 precursor
NM_001385164.1	NP_001372093.1	major histocompatibility complex class I-related gene protein isoform 3 precursor
NM_001531.3	NP_001522.1	major histocompatibility complex class I-related gene protein isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables T cell receptor binding	IDA IDA: Inferred from direct assay	26795251	GOA
enables beta-2-microglobulin binding	IDA IDA: Inferred from direct assay	26795251	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23051753	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antigen processing and presentation of exogenous antigen	IDA IDA: Inferred from direct assay	27043408	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	20581831	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	27527800	GOA
involved in positive regulation of T cell mediated cytotoxicity directed against tumor cell target	IDA IDA: Inferred from direct assay	31959982	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	27043408	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21190736	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	27043408	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	27043408	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	27043408	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MR1 Protein Structure

MHC_I

C1-set

0
100
200
300
341 a.a.

Protein Preferred Names

Protein Names

major histocompatibility complex class I-related gene protein

MHC class I-like antigen MR-1

MR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MR1	Q95460	FATE1	Homo sapiens	Q969F0	Y2H Array	25416956
Intra	MR1	Q95460	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124004	Acetyl-6-formylpterin		≥95.0%	Unkown
HY-157194	RL-6-Me-7-OH		96.56%	Unkown
HY-W168754	DB28	Inhibitor	99.92%	Unkown
HY-157281	Photolumazine III		99.96%	Unkown
HY-157200	2,4-DA-6-FP		/	Unkown
HY-RS08637	MR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-157282	Photolumazine I		/	Unkown
HY-163122	5-Formylsalicylic acid		/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990134	Anti-Mouse CD40L/CD154 Antibody (MR-1)	Inhibitor	95.00%	Unkown
HY-P990269	Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1)	Inhibitor	/	Unkown
HY-P990270	Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MR1	VGNC	VGNC:100013
Mus musculus	MR1	MGD	MGI:1195463
Bos taurus	MR1	VGNC	VGNC:31595
Rattus norvegicus	MR1	RGD	RGD:1593291
Macaca fascicularis	MR1	NCBI
Others	MR1	NCBI

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