NUDT2 - nudix hydrolase 2 Gene

Homo sapiens

Also known as APAH1; IDDPN

Gene ID: 318 | Gene type: protein coding

About NUDT2

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,329,569-34,343,699 (from NCBI)

This gene has 4 transcripts (splice variants), 203 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 11.6), prostate (RPKM 10.9) and 25 other tissues.

Summary

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The Enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

NUDT2 Products(4)

mRNA	Protein	Name
NM_001161.5	NP_001152.1	bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
NM_001244390.2	NP_001231319.1	bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
NM_147172.3	NP_671701.1	bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
NM_147173.3	NP_671702.1	bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT2 Protein Structure

NUDIX

0
100
147 a.a.

Protein Preferred Names

Protein Names

bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Ap4A hydrolase 1

Recombinant NUDT2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77108	NUDT2 Protein, Human (His)	P50583 (M1-A147)	≥95%

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder With Or Without Peripheral Neuropathy

IDDPN

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09668	NUDT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NUDT2	VGNC	VGNC:68590
Rattus norvegicus	NUDT2	RGD	RGD:1303023
Bos taurus	NUDT2	VGNC	VGNC:32335
Mus musculus	NUDT2	MGD	MGI:1913651
Canis familiaris	NUDT2	VGNC	VGNC:44033
Others	NUDT2	NCBI

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