1. Gene
  2. HNRNPK - heterogeneous nuclear ribonucleoprotein K Gene

HNRNPK - heterogeneous nuclear ribonucleoprotein K Gene

Homo sapiens

Also known as AUKS; CSBP; TUNP; HNRPK

Gene ID: 3190 | Gene type: protein coding

About HNRNPK

Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:83,968,083-83,980,615 (from NCBI)

This gene has 34 transcripts (splice variants), 348 orthologues, 12 paralogues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 179.3), lymph node (RPKM 145.8) and 25 other tissues.

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among Other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]

HNRNPK Products(6)

mRNA Protein Name
NM_001318186.2 NP_001305115.1 heterogeneous nuclear ribonucleoprotein K isoform c
NM_001318187.2 NP_001305116.1 heterogeneous nuclear ribonucleoprotein K isoform d
NM_001318188.2 NP_001305117.1 heterogeneous nuclear ribonucleoprotein K isoform b
NM_002140.5 NP_002131.2 heterogeneous nuclear ribonucleoprotein K isoform a
NM_031262.4 NP_112552.1 heterogeneous nuclear ribonucleoprotein K isoform b
NM_031263.4 NP_112553.1 heterogeneous nuclear ribonucleoprotein K isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16004877 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9651361 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
10749975 GOA
Cellular Component GO Annotation Evidence Reference Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in chromatin IDA
IDA: Inferred from direct assay
20371611 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
33174841 GOA
located in nucleus IDA
IDA: Inferred from direct assay
33174841 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
33174841 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPK Protein Structure

ROKNT

ROKNT: ROKNT (NUC014) domain (1 - 43)

KH_1

KH_1: KH domain (45 - 103)

KH_1

KH_1: KH domain (147 - 209)

KH_1

KH_1: KH domain (389 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 463 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein K

dC-stretch binding protein

HNRNPK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HNRNPK P61978 RTP5 Homo sapiens Q14D33 25416956
Intra
HNRNPK P61978 RTP5 Homo sapiens Q14D33 25416956
Intra
HNRNPK P61978 RTP5 Homo sapiens Q14D33 25416956
Intra
HNRNPK P61978 ZNF792 Homo sapiens Q3KQV3 25416956
Intra
HNRNPK P61978 ZNF792 Homo sapiens Q3KQV3 25416956
Intra
HNRNPK P61978 ZNF792 Homo sapiens Q3KQV3 25416956
Intra
HNRNPK P61978 C6orf226 Homo sapiens Q5I0X4 25416956
Intra
HNRNPK P61978 MARK4 Homo sapiens Q6IPE9 25416956
Intra
HNRNPK P61978 MARK4 Homo sapiens Q6IPE9 25416956
Intra
HNRNPK P61978 MARK4 Homo sapiens Q6IPE9 25416956
Intra
HNRNPK P61978 q8n9j2_human Homo sapiens Q8N9J2 25416956
Intra
HNRNPK P61978 q8n9j2_human Homo sapiens Q8N9J2 25416956
Intra
HNRNPK P61978 q8n9j2_human Homo sapiens Q8N9J2 25416956
Intra
HNRNPK P61978 PCDHB14 Homo sapiens Q9Y5E9 25416956
Intra
HNRNPK P61978 PCDHB14 Homo sapiens Q9Y5E9 25416956
Intra
HNRNPK P61978 PCDHB14 Homo sapiens Q9Y5E9 25416956
Intra
HNRNPK P61978 JPH3 Homo sapiens Q8WXH2 32814053
Intra
HNRNPK P61978 JPH3 Homo sapiens Q8WXH2 32814053
Intra
HNRNPK P61978 JPH3 Homo sapiens Q8WXH2 32814053
Intra
HNRNPK P61978 PRPF31 Homo sapiens Q8WWY3 25416956
Intra
HNRNPK P61978 PRPF31 Homo sapiens Q8WWY3 25416956
Intra
HNRNPK P61978 PRR3 Homo sapiens P79522 25416956
Intra
HNRNPK P61978 PRR3 Homo sapiens P79522 25416956
Intra
HNRNPK P61978 PRR3 Homo sapiens P79522 25416956
Intra
HNRNPK P61978 YTHDC1 Homo sapiens Q96MU7 25416956
Intra
HNRNPK P61978 YTHDC1 Homo sapiens Q96MU7 25416956
Intra
HNRNPK P61978 DALRD3 Homo sapiens Q5D0E6 25416956
Intra
HNRNPK P61978 RBM3 Homo sapiens P98179 25416956
Intra
HNRNPK P61978 RBM3 Homo sapiens P98179 25416956
Intra
HNRNPK P61978 GRB2 Homo sapiens P62993 25416956
Intra
HNRNPK P61978 QKI Homo sapiens Q96PU8 25416956
Intra
HNRNPK P61978 CIRBP Homo sapiens Q14011 25416956
Intra
HNRNPK P61978 GRB2 Homo sapiens P62993 20936779
Intra
HNRNPK P61978 QKI Homo sapiens Q96PU8 25416956
Intra
HNRNPK P61978 QKI Homo sapiens Q96PU8 16713569
Intra
HNRNPK P61978 CIRBP Homo sapiens Q14011 25416956
Intra
HNRNPK P61978 GRB2 Homo sapiens P62993 25416956
Intra
HNRNPK P61978 QKI Homo sapiens Q96PU8 16189514
Intra
HNRNPK P61978 HNRNPU Homo sapiens Q00839 33174841
Intra
HNRNPK P61978 MATR3 Homo sapiens P43243 25416956
Intra
HNRNPK P61978 MATR3 Homo sapiens P43243 16189514
Intra
HNRNPK P61978 MATR3 Homo sapiens P43243 25416956
Intra
HNRNPK P61978 TP53 Homo sapiens P04637 21821029
Intra
HNRNPK P61978 TP53 Homo sapiens P04637 23092970
Intra
HNRNPK P61978 TARDBP Homo sapiens Q13148 32814053
Intra
HNRNPK P61978 TARDBP Homo sapiens Q13148 32814053
Intra
HNRNPK P61978 TARDBP Homo sapiens Q13148 32814053
Intra
HNRNPK P61978 MDM2 Homo sapiens Q00987 19249676
Intra
HNRNPK P61978 AURKA Homo sapiens O14965 21821029
Intra
HNRNPK P61978 AURKA Homo sapiens O14965 21821029
Intra
HNRNPK P61978 DOCK2 Homo sapiens Q92608 25416956
Intra
HNRNPK P61978 ADRB2 Homo sapiens P07550 28298427
Intra
HNRNPK P61978 ADRB2 Homo sapiens P07550 28298427
Intra
HNRNPK P61978 HNRNPLL Homo sapiens Q8WVV9 25416956
Intra
HNRNPK P61978 HNRNPLL Homo sapiens Q8WVV9 25416956
Intra
HNRNPK P61978 SNRPA Homo sapiens P09012
Y2H
22365833
Intra
HNRNPK P61978 SRC Homo sapiens P12931 17178840
Intra
HNRNPK P61978 SRC Homo sapiens P12931 17178840
Intra
HNRNPK P61978 U2AF1 Homo sapiens Q01081 25416956
Intra
HNRNPK P61978 U2AF1 Homo sapiens Q01081 25416956
Intra
HNRNPK P61978 ZFC3H1 Homo sapiens G3V1X1 25416956
Intra
HNRNPK P61978 ATXN10 Homo sapiens Q9UBB4 32814053
Intra
HNRNPK P61978 ATXN10 Homo sapiens Q9UBB4 32814053
Intra
HNRNPK P61978 ATXN10 Homo sapiens Q9UBB4 32814053
Intra
HNRNPK P61978 NDUFV2 Homo sapiens P19404 32814053
Intra
HNRNPK P61978 NDUFV2 Homo sapiens P19404 32814053
Intra
HNRNPK P61978 NDUFV2 Homo sapiens P19404 32814053
Intra
HNRNPK P61978 SPG7 Homo sapiens Q9UQ90 25416956
Intra
HNRNPK P61978 HNRNPL Homo sapiens P14866 33174841
Intra
HNRNPK P61978 HNRNPL Homo sapiens P14866 33174841
Intra
HNRNPK P61978 HNRNPL Homo sapiens P14866 33174841
Intra
HNRNPK P61978 RASD1 Homo sapiens Q9Y272 25416956
Intra
HNRNPK P61978 RASD1 Homo sapiens Q9Y272 25416956
Intra
HNRNPK P61978 RASD1 Homo sapiens Q9Y272 25416956
Intra
HNRNPK P61978 SORBS3 Homo sapiens O60504 16189514
Intra
HNRNPK P61978 SORBS3 Homo sapiens O60504 25416956
Intra
HNRNPK P61978 RBMX Homo sapiens P38159 16189514
Intra
HNRNPK P61978 RBMX Homo sapiens P38159
Y2H
22365833
Intra
HNRNPK P61978 RBMX Homo sapiens P38159 25416956
Intra
HNRNPK P61978 RBMX Homo sapiens P38159 25416956
Intra
HNRNPK P61978 ABI2 Homo sapiens Q9NYB9 29892012
Intra
HNRNPK P61978 ABI2 Homo sapiens Q9NYB9 25416956
Intra
HNRNPK P61978 GFAP Homo sapiens P14136 32814053
Intra
HNRNPK P61978 GFAP Homo sapiens P14136 32814053
Intra
HNRNPK P61978 GFAP Homo sapiens P14136 32814053
Intra
HNRNPK P61978 FBXL18 Homo sapiens Q96D16 25416956
Intra
HNRNPK P61978 FBXL18 Homo sapiens Q96D16 25416956
Intra
HNRNPK P61978 FBXL18 Homo sapiens Q96D16 25416956
Intra
HNRNPK P61978 AQP5 Homo sapiens P55064 25416956
Intra
HNRNPK P61978 RBM42 Homo sapiens Q9BTD8 16189514
Intra
HNRNPK P61978 TERF2IP Homo sapiens Q9NYB0 21044950
Intra
HNRNPK P61978 TERF2IP Homo sapiens Q9NYB0 21044950
Intra
HNRNPK P61978 PRMT1 Homo sapiens Q99873 19101556
Intra
HNRNPK P61978 PRMT1 Homo sapiens Q99873 19101556
Cross
HNRNPK P61978 C'204L African swine fever virus Q8V1E7 18775702
Cross
HNRNPK P61978 C'204L African swine fever virus Q8V1E7
IF
18775702
Cross
HNRNPK P61978 C'204L African swine fever virus Q8V1E7
Y2H
18775702
Intra
HNRNPK P61978 DBH Homo sapiens P09172 32814053
Intra
HNRNPK P61978 DBH Homo sapiens P09172 32814053
Intra
HNRNPK P61978 DBH Homo sapiens P09172 32814053
Intra
HNRNPK P61978 RBMY1A1 Homo sapiens P0DJD3 25416956
Intra
HNRNPK P61978 RBMY1A1 Homo sapiens P0DJD3 25416956
Intra
HNRNPK P61978 RBMY1F Homo sapiens Q15415 25416956
Intra
HNRNPK P61978 RBMY1F Homo sapiens Q15415 25416956
Intra
HNRNPK P61978 ZNF385C Homo sapiens Q66K41 25416956
Intra
HNRNPK P61978 ZNF385C Homo sapiens Q66K41 25416956
Cross
HNRNPK P61978 P29846-PRO_0000037666 Hepatitis C virus P29846-PRO_0000037666 9651361
Cross
HNRNPK P61978 P29846-PRO_0000037666 Hepatitis C virus P29846-PRO_0000037666
Y2H
9651361
Cross
HNRNPK P61978 P29846-PRO_0000037666 Hepatitis C virus P29846-PRO_0000037666 9651361
Cross
HNRNPK P61978 P29846-PRO_0000037666 Hepatitis C virus P29846-PRO_0000037666 9651361
Cross
HNRNPK P61978 P29846-PRO_0000037666 Hepatitis C virus P29846-PRO_0000037666 9651361
Cross: Cross-species interaction Intra: Intraspecies interaction

HNRNPK Antibodies

Cat. No. Product Name Application Reactivity
HY-P81449 hnRNP K Antibody (YA1194) IHC-P Human

Related Diseases

Diseases Alias
Au-Kline Syndrome

AUKS

Okamoto Syndrome

Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome

Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation

Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9q21.3 Microdeletion

9q21.3 Microdeletion Syndrome

Del(9)(Q21.3)

Spinocerebellar Ataxia 10

Spinocerebellar Ataxia Type 10

SCA10

Spinocerebellar Ataxia-10

Ataxia, Spinocerebellar, Type 10

Stomatitis
Mouth Disease

Mouth Diseases

Mouth Disorders

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Ptosis

Blepharoptosis

Drooping Eyelid

Droopy Eyelid

Ptosis Of Eyelid

Paralysis Of Levator Palpebrae Superioris

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus HNRNPK MGD MGI:99894
Bos taurus HNRNPK VGNC VGNC:29897
Macaca mulatta HNRNPK VGNC VGNC:103271
Felis catus HNRNPK VGNC VGNC:67609
Rattus norvegicus HNRNPK RGD RGD:71058
Canis familiaris HNRNPK VGNC VGNC:54846