HOXA5 - homeobox A5 Gene

Homo sapiens

Also known as HOX1; HOX1C; HOX1.3

Gene ID: 3202 | Gene type: protein coding

About HOXA5

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,141,052-27,143,681 (from NCBI)

This gene has 2 transcripts (splice variants), 195 orthologues and 42 paralogues. Biased expression in adrenal (RPKM 48.1), lung (RPKM 14.3) and 8 other tissues.

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]

HOXA5 Products(1)

mRNA	Protein	Name
NM_019102.4	NP_061975.2	homeobox protein Hox-A5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8657138	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10879542	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10879542	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10879542	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15545268	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	17957028	GOA
involved in negative regulation of erythrocyte differentiation	IDA IDA: Inferred from direct assay	10397719	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	10879542	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	10875927	GOA
involved in positive regulation of myeloid cell differentiation	IDA IDA: Inferred from direct assay	10397719	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10879542	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15545268	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXA5 Protein Structure

Homeobox

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

homeobox protein Hox-A5

homeo box 1C

HOXA5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HOXA5	P20719	CTBP2	Homo sapiens	P56545-3	Validated Y2H	32296183
Intra	HOXA5	P20719	CTBP2	Homo sapiens	P56545-3	Y2H Prey Pooling	32296183
Intra	HOXA5	P20719	CTBP2	Homo sapiens	P56545-3	Y2H Array	32296183
Intra	HOXA5	P20719	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	HOXA5	P20719	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	HOXA5	P20719	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	HOXA5	P20719	PBX2	Homo sapiens	P40425	Validated Y2H	32296183
Intra	HOXA5	P20719	PBX2	Homo sapiens	P40425	Y2H Array	32296183
Intra	HOXA5	P20719	PBX2	Homo sapiens	P40425	Y2H Prey Pooling	32296183
Intra	HOXA5	P20719	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	HOXA5	P20719	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	HOXA5	P20719	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	HOXA5	P20719	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	HOXA5	P20719	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	HOXA5	P20719	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	HOXA5	P20719	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	HOXA5	P20719	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Embryonal Carcinoma

Embryonal Neoplasm	Embryonal Cancer
Primary Extragonadal Embryonal Carcinoma	Embryo Neoplasm
Carcinoma Embryonal	Cancer Embryonal
Carcinoma, Embryonal	Extragonadal Embryonal Carcinoma
Cancer, Embryonal

Cardiomyopathy, Familial Hypertrophic, 20

Hypertrophic Cardiomyopathy 20	CMH20
Cardiomyopathy, Hypertrophic, 20	Cardiomyopathy Familial Hypertrophic 20
Cardiomyopathy, Familial Hypertrophic 20	Cardiomyopathy, Hypertrophic, Familial, Type 20

Mediastinal Gray Zone Lymphoma

Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma

Mediastinal Malignant Lymphoma

Lymphoma Of Mediastinum

Mediastinal Lymphoma

Clubfoot

Congenital Talipes Equinovarus	Congenital Clubfoot
Congenital Equinovarus	Equinovarus Deformity Of Foot
Club Foot

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06300	HOXA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HOXA5	VGNC	VGNC:29913
Macaca mulatta	HOXA5	VGNC	VGNC:108414
Felis catus	HOXA5	VGNC	VGNC:102601
Canis familiaris	HOXA5	VGNC	VGNC:54769
Mus musculus	HOXA5	MGD	MGI:96177
Rattus norvegicus	HOXA5	RGD	RGD:620609

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