Gpr183 - G protein-coupled receptor 183 Gene

Mus musculus

Also known as Ebi2

Gene ID: 321019 | Gene type: protein coding

About Gpr183

Chromosome 14: 122,189,963-122,202,607 reverse strand.GRCm39:CM001007.3

This gene has 2 transcripts (splice variants), 207 orthologues, 5 paralogues and is associated with 12 phenotypes. Broad expression in spleen adult (RPKM 9.1), mammary gland adult (RPKM 4.9) and 15 other tissues.

Summary

Enables oxysterol binding activity. Involved in several processes, including dendritic cell homeostasis; leukocyte chemotaxis; and leukocyte differentiation. Acts upstream of or within leukocyte chemotaxis. Predicted to be located in plasma membrane. Is expressed in several structures, including Peyer's patch; central nervous system; genitourinary system; immune system; and intestine. Orthologous to human GPR183 (G protein-coupled receptor 183). [provided by Alliance of Genome Resources, Apr 2022]

Gpr183 Products(1)

mRNA	Protein	Name
NM_183031.2	NP_898852.2	G-protein coupled receptor 183

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables oxysterol binding	IDA IDA: Inferred from direct assay	21796211	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell chemotaxis	IMP IMP: Inferred from mutant phenotype	27147029	MGI
involved in T follicular helper cell differentiation	IMP IMP: Inferred from mutant phenotype	27147029	MGI
involved in adaptive immune response	IMP IMP: Inferred from mutant phenotype	23502855	MGI
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	26438360	MGI
involved in dendritic cell chemotaxis	IMP IMP: Inferred from mutant phenotype	23502855	MGI
involved in dendritic cell homeostasis	IMP IMP: Inferred from mutant phenotype	23502855	MGI
involved in humoral immune response	IMP IMP: Inferred from mutant phenotype	19597478	MGI
acts upstream of or within leukocyte chemotaxis	IDA IDA: Inferred from direct assay	25348153	MGI
involved in mature B cell differentiation involved in immune response	IMP IMP: Inferred from mutant phenotype	19597478	MGI
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	26438360	MGI
involved in positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	21673108	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpr183 Protein Structure

7tmA_EBI2

0
100
200
300
357 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor 183

EBV-induced G-protein coupled receptor 2 homolog	Epstein-Barr virus induced gene 2
epstein-Barr virus-induced G-protein coupled receptor 2 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113962	7α,25-Dihydroxycholesterol	Agonist	≥99.0%	Unkown
HY-162011	GPR183 antagonist-2	Antagonist	99.96%	Unkown
HY-147222	SAE-14	Antagonist	98.26%	Unkown
HY-113962S	7α,25-Dihydroxycholesterol-d6		/	Unkown
HY-162618	PSB-KK1445	Agonist	/	Unkown
HY-163796	GPR183-IN-2	Inhibitor	99.90%	Unkown
HY-157939	GPR183 antagonist-3	Antagonist	/	Unkown
HY-163795	GPR183-IN-1	Inhibitor	/	Unkown
HY-RS05690	GPR183 Human Pre-designed siRNA Set A		/	Unkown
HY-RS05691	Gpr183 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS05692	Gpr183 Rat Pre-designed siRNA Set A		/	Unkown
HY-400897	7α,25-Dihydroxycholesterol intermediate-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpr183	NCBI	NCBI:1880

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