HOXC10 - homeobox C10 Gene

Homo sapiens

Also known as HOX3I

Gene ID: 3226 | Gene type: protein coding

About HOXC10

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,985,146-53,990,279 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 42 paralogues. Biased expression in kidney (RPKM 15.8), skin (RPKM 3.7) and 5 other tissues.

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]

HOXC10 Products(1)

mRNA	Protein	Name
NM_017409.4	NP_059105.2	homeobox protein Hox-C10

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10835276	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10835276	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	28186086	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10835276	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXC10 Protein Structure

Homeobox

0
100
200
300
342 a.a.

Protein Preferred Names

Protein Names

homeobox protein Hox-C10

homeo box C10

HOXC10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HOXC10	Q9NYD6	USP21	Homo sapiens	Q9UK80	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06314	HOXC10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HOXC10	MGD	MGI:96192
Canis familiaris	HOXC10	VGNC	VGNC:41756
Felis catus	HOXC10	VGNC	VGNC:67625
Macaca mulatta	HOXC10	VGNC	VGNC:73506
Bos taurus	HOXC10	VGNC	VGNC:56206
Rattus norvegicus	HOXC10	RGD	RGD:1307250

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