2. Gene
  3. USP21 - ubiquitin specific peptidase 21 Gene

USP21 - ubiquitin specific peptidase 21 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as USP16; USP23

Gene ID: 27005 | Gene type: protein coding

About USP21

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,159,500-161,165,723 (from NCBI)

This gene has 11 transcripts (splice variants), 190 orthologues and 71 paralogues. Ubiquitous expression in ovary (RPKM 11.4), testis (RPKM 9.2) and 25 other tissues.

Summary

This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

USP21 Products(4)

mRNA Protein Name
NM_001014443.3 NP_001014443.1 ubiquitin carboxyl-terminal hydrolase 21 isoform c
NM_001319847.2 NP_001306776.1 ubiquitin carboxyl-terminal hydrolase 21 isoform a
NM_001319848.2 NP_001306777.1 ubiquitin carboxyl-terminal hydrolase 21 isoform b
NM_012475.5 NP_036607.3 ubiquitin carboxyl-terminal hydrolase 21 isoform c

USP21 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (212 - 555)

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  • 565 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 21

NEDD8-specific protease

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13453 BAY 11-7082 99.98% Unkown
HY-153045 BAY-805 Inhibitor 99.95% Unkown
HY-153045A BAY-728 99.92% Unkown
HY-158439 anti-TNBC agent-7 Modulator / Unkown
HY-RS15532 USP21 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus USP21 VGNC VGNC:97680
Mus musculus USP21 MGD MGI:1353665
Macaca mulatta USP21 VGNC VGNC:78741
Canis familiaris USP21 VGNC VGNC:53133
Bos taurus USP21 VGNC VGNC:52843
Rattus norvegicus USP21 RGD RGD:1588822
Others USP21 NCBI