2. Gene
  3. USP21 - ubiquitin specific peptidase 21 Gene

USP21 - ubiquitin specific peptidase 21 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as USP16; USP23

Gene ID: 27005 | Gene type: protein coding

About USP21

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,159,500-161,165,723 (from NCBI)

This gene has 11 transcripts (splice variants), 190 orthologues and 71 paralogues. Ubiquitous expression in ovary (RPKM 11.4), testis (RPKM 9.2) and 25 other tissues.

Summary

This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

USP21 Products(4)

mRNA Protein Name
NM_001014443.3 NP_001014443.1 ubiquitin carboxyl-terminal hydrolase 21 isoform c
NM_001319847.2 NP_001306776.1 ubiquitin carboxyl-terminal hydrolase 21 isoform a
NM_001319848.2 NP_001306777.1 ubiquitin carboxyl-terminal hydrolase 21 isoform b
NM_012475.5 NP_036607.3 ubiquitin carboxyl-terminal hydrolase 21 isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
10799498 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
26100909 GOA
enables cysteine-type peptidase activity IMP
IMP: Inferred from mutant phenotype
10799498 GOA
enables deNEDDylase activity IDA
IDA: Inferred from direct assay
10799498 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
32011234 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP21 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (212 - 555)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 565 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 21

NEDD8-specific protease

USP21 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
USP21 Q9UK80 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
USP21 Q9UK80 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
USP21 Q9UK80 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
USP21 Q9UK80 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
USP21 Q9UK80 CPSF6 Homo sapiens Q16630-2
Y2H Prey Pooling
32296183
Intra
USP21 Q9UK80 CPSF6 Homo sapiens Q16630-2
Y2H Array
32296183
Intra
USP21 Q9UK80 HOXC10 Homo sapiens Q9NYD6
Y2H Prey Pooling
32296183
Intra
USP21 Q9UK80 HOXC10 Homo sapiens Q9NYD6
Y2H Array
32296183
Intra
USP21 Q9UK80 KCTD9 Homo sapiens Q7L273
Y2H Prey Pooling
32296183
Intra
USP21 Q9UK80 KCTD9 Homo sapiens Q7L273
Y2H Array
32296183
Intra
USP21 Q9UK80 UCHL1 Homo sapiens P09936
Anti Tag CoIP
19615732
Intra
USP21 Q9UK80 EFEMP2 Homo sapiens O95967
Y2H Array
32296183
Intra
USP21 Q9UK80 EFEMP2 Homo sapiens O95967
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13453 BAY 11-7082 99.98% Unkown
HY-153045 BAY-805 Inhibitor 99.95% Unkown
HY-153045A BAY-728 99.92% Unkown
HY-158439 anti-TNBC agent-7 Modulator / Unkown
HY-RS15532 USP21 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus USP21 VGNC VGNC:97680
Mus musculus USP21 MGD MGI:1353665
Macaca mulatta USP21 VGNC VGNC:78741
Canis familiaris USP21 VGNC VGNC:53133
Bos taurus USP21 VGNC VGNC:52843
Rattus norvegicus USP21 RGD RGD:1588822
Others USP21 NCBI