HOXC11 - homeobox C11 Gene

Homo sapiens

Also known as HOX3H

Gene ID: 3227 | Gene type: protein coding

About HOXC11

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,973,126-53,977,643 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues, 42 paralogues and is associated with 41 phenotypes. Low expression observed in reference dataset.

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

HOXC11 Products(1)

mRNA	Protein	Name
NM_014212.4	NP_055027.1	homeobox protein Hox-C11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9582375	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9582375	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23275563	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9582375	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXC11 Protein Structure

DUF3528

Homeobox

0
100
200
304 a.a.

Protein Preferred Names

Protein Names

homeobox protein Hox-C11

homeo box C11

HOXC11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HOXC11	O43248	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	HOXC11	O43248	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	HOXC11	O43248	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	HOXC11	O43248	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	HOXC11	O43248	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	HOXC11	O43248	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	HOXC11	O43248	PSMA1	Homo sapiens	P25786	Validated Y2H	32296183
Intra	HOXC11	O43248	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	HOXC11	O43248	HTT	Homo sapiens	P42858	Y2H Prey Pooling	23275563
Intra	HOXC11	O43248	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	HOXC11	O43248	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	HOXC11	O43248	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	HOXC11	O43248	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	HOXC11	O43248	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	HOXC11	O43248	TRIP10	Homo sapiens	Q15642-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ectodermal Dysplasia 4, Hair/Nail Type

Pure Hair And Nail Ectodermal Dysplasia	ECTD4
Ectodermal Dysplasia, Pure Hair-Nail Type	Ectodermal Dysplasia, 'Pure' Hair/Nail Type
Hned	Hair-Nail Ectodermal Dysplasia
Phned	Ectodermal Dysplasia Pure Hair-Nail Type
Ectodermal Dysplasia, 'Pure' Hair-Nail Type	Dysplasia, Ectodermal, Type 4, Hair/Nail

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06315	HOXC11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HOXC11	RGD	RGD:6489991
Canis familiaris	HOXC11	VGNC	VGNC:57427
Macaca mulatta	HOXC11	VGNC	VGNC:99942
Felis catus	HOXC11	VGNC	VGNC:84030
Bos taurus	HOXC11	VGNC	VGNC:56207
Mus musculus	HOXC11	MGD	MGI:96193

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