HPGD - 15-hydroxyprostaglandin dehydrogenase Gene

Homo sapiens

Also known as PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1

Gene ID: 3248 | Gene type: protein coding

About HPGD

Cytogenetic location: 4q34.1 Genomic coordinates (GRCh38): 4:174,490,175-174,522,893 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and is associated with 6 phenotypes. Biased expression in urinary bladder (RPKM 176.8), stomach (RPKM 67.9) and 11 other tissues.

Summary

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded Enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

HPGD Products(8)

mRNA	Protein	Name
NM_001256305.2	NP_001243234.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 4
NM_001363574.2	NP_001350503.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 6
NM_001256301.1	NP_001243230.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3
XR_938728.3
NM_000860.6	NP_000851.2	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1
NM_001256307.2	NP_001243236.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3
NM_001256306.2	NP_001243235.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 5
NM_001145816.3	NP_001139288.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	2025296	GOA
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IMP IMP: Inferred from mutant phenotype	8086429	GOA
enables NAD binding	IDA IDA: Inferred from direct assay	10198228	GOA
enables NAD+ binding	IDA IDA: Inferred from direct assay	16828555	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21072165	GOA
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA IDA: Inferred from direct assay	16757471	GOA
enables prostaglandin E receptor activity	IDA IDA: Inferred from direct assay	10198228	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in female pregnancy	IDA IDA: Inferred from direct assay	15531523	GOA
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	15574495	GOA
involved in parturition	IDA IDA: Inferred from direct assay	15531523	GOA
involved in prostaglandin metabolic process	IDA IDA: Inferred from direct assay	16828555	GOA
involved in regulation of prostaglandin catabolic process	IMP IMP: Inferred from mutant phenotype	8086429	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	15574495	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HPGD Protein Structure

adh_short

0
100
200
266 a.a.

Protein Preferred Names

Protein Names

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

15-hydroxyprostaglandin dehydrogenase (NAD(+))	NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
eicosanoid/docosanoid dehydrogenase	hydroxyprostaglandin dehydrogenase 15-(NAD)
prostaglandin dehydrogenase 1	short chain dehydrogenase/reductase family 36C member 1

Recombinant HPGD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70297	15-PGDH/HPGD Protein, Human (HEK293, His)	P15428-1 (M1-Q266)	≥95%
HY-P75547	15-PGDH/HPGD Protein, Human (His)	P15428-1/NP_000851.2 (M1-Q266)	≥95%

Related Diseases

Diseases

Alias

Colorectal Adenoma

Colorectal Adenomas

Adenoma Of Large Intestine

Colon Adenoma

Adenomatous Polyp Of Colon

Gastric Tubular Adenocarcinoma

Tubular Adenocarcinoma Of Stomach

Gastritis, Familial Giant Hypertrophic

Menetrier Disease	Gastric Mucosal Hypertrophy
Giant Hypertrophic Gastritis	Hypertrophic Gastropathy
Gastritis, Hypertrophic	Familial Giant Hypertrophic Gastritis
Giant Rugal Hypertrophy Of Stomach	Hypertrophic Gastritis
Gastroenteropathy, Protein Losing	Giant Hypertrophic Gastropathy
Giant Hypertrophy Of The Gastric Mucosa	Hypoproteinemic Hypertrophic Gastropathy
Menetrier'S Disease	Giant Hypertrophic Hypersecretory Gastritis

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1

Cranioosteoarthropathy	PHOAR1
Pachydermoperiostosis, Autosomal Recessive	Touraine-Solente-Gole Syndrome
Pho, Autosomal Recessive	Pdp, Autosomal Recessive
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1	Cranio Osteoarthropathy
Cranio-Osteoarthropathy	Currarino Disease
Currarino Idiopathic Osteoarthropathy	Reginato-Schiapachasse Syndrome
Touraine-Solente-Golé Syndrome	COA
Pachydermoperiostosis Autosomal Recessive	Pdp Autosomal Recessive
Pho Autosomal Recessive	Osteoarthropathy, Hypertrophic, Primary, Autosomal Recessive, Type 1
Osteoarthropathy, Primary Hypertrophic	Reginato Schiapachasse Syndrome

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus	PDA1
Pda	Ductus Arteriosus, Patent
Patent Ductus Arteriosus, Susceptibility To	Patent Ductus Botalli
Patency Of The Ductus Arteriosus	Patent Ductus Arteriosus Familial
Ductus Arteriosus Patent	Patent Ductus Arteriosus - Persisting Type

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Primary Hypertrophic Osteoarthropathy

Pachydermoperiostosis Syndrome	Osteoarthropathy, Primary Hypertrophic
Pachydermoperiostosis Of Nail	Idiopathic Hypertrophic Osteoarthropathy
Pho

Acroosteolysis

Acro-Osteolysis

Ureteral Obstruction

Colonic Benign Neoplasm

Colon Neoplasm	Colonic Mass
Colonic Tumor	Neoplasm Of Colon
Neoplasm Of The Colon	Colonic Neoplasms
Colon Cancer	Colon Carcinoma Nos
Colonic Cancer	Metastatic Colon Cancer Nos

Lymphangioma

Lymphatic Malformation	Lymphatic Malformations
Benign Lymphangioma	Congenital Lymphangioma
Lymphangiomas

Periostitis

Digital Clubbing, Isolated Congenital

Isolated Congenital Digital Clubbing	DIGC
Clubbing Of Digits	Acropachy, Hereditary
Isolated Congenital Acropachy	Isolated Congenital Nail Clubbing
Hereditary Acropachy

Secondary Hypertrophic Osteoarthropathy

Osteoarthropathy, Secondary Hypertrophic	Bamberger-Marie Disease
Hpoa - Hypertrophic Pulmonary Osteoarthropathy	Hypertrophic Pulmonary Osteoarthropathy
Marie Bamberger Disease

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Congenital Anomaly Of Heart
Heart Defect	Heart Malformation
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Acromegaloid Changes, Cutis Verticis Gyrata, And Corneal Leukoma

Pachydermoperiostosis	Rosenthal-Kloepfer Syndrome
Pdp	Acromegaloid Changes, Cutis Verticis Gyrata And Corneal Leukoma
Idiopathic Hypertrophic Osteoarthropathy	Primary Hypertrophic Osteoarthropathy
Touraine Solente Gole Syndrome	Touraine-Solente-Gole Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108259	HQL-79	Inhibitor	99.89%	Unkown
HY-110167	TFC 007	Inhibitor	98.01%	Unkown
HY-12791	hPGDS-IN-1	Inhibitor	99.92%	Unkown
HY-10439	HPGDS inhibitor 1	Inhibitor	99.04%	Unkown
HY-109134	Pizuglanstat	Inhibitor	99.70%	Unkown
HY-139972	PROTAC(H-PGDS)-7		99.42%	Unkown
HY-126134	HPGDS inhibitor 2	Inhibitor	99.72%	Unkown
HY-146662	HPGDS inhibitor 3	Inhibitor	/	Unkown
HY-157577	PROTAC(H-PGDS)-8	Degrader	/	Unkown
HY-RS06338	HPGD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06339	Hpgd Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06340	Hpgd Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06341	HPGDS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-109134A	Pizuglanstat hydrate	Inhibitor	/	Unkown
HY-120581	ML388	Inhibitor	/	Unkown
HY-139171	F092	Inhibitor	99.79%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HPGD	VGNC	VGNC:56973
Macaca mulatta	HPGD	VGNC	VGNC:73512
Felis catus	HPGD	VGNC	VGNC:67638
Canis familiaris	HPGD	VGNC	VGNC:49605
Mus musculus	HPGD	MGD	MGI:108085
Rattus norvegicus	HPGD	RGD	RGD:620087
Others	HPGD	NCBI

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