PRMT2 - protein arginine methyltransferase 2 Gene

Homo sapiens

Also known as HRMT1L1

Gene ID: 3275 | Gene type: protein coding

About PRMT2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:46,635,674-46,665,124 (from NCBI)

This gene has 15 transcripts (splice variants), 159 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 11.6), spleen (RPKM 8.9) and 25 other tissues.

Summary

Enables several functions, including nuclear receptor binding activity; peroxisome proliferator activated receptor binding activity; and protein homodimerization activity. Involved in several processes, including histone methylation; regulation of Androgen Receptor signaling pathway; and regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PRMT2 Products(8)

mRNA	Protein	Name
NM_001242864.3	NP_001229793.1	protein arginine N-methyltransferase 2 isoform 2
NM_001242865.3	NP_001229794.1	protein arginine N-methyltransferase 2 isoform 3
NM_001242866.3	NP_001229795.1	protein arginine N-methyltransferase 2 isoform 4
NM_001286676.2	NP_001273605.1	protein arginine N-methyltransferase 2 isoform 5
NM_001286677.2	NP_001273606.1	protein arginine N-methyltransferase 2 isoform 6
NM_001286678.2	NP_001273607.1	protein arginine N-methyltransferase 2 isoform 7
NM_001535.5	NP_001526.2	protein arginine N-methyltransferase 2 isoform 1
NM_206962.4	NP_996845.1	protein arginine N-methyltransferase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone methyltransferase activity	IDA IDA: Inferred from direct assay	19405910	GOA
enables nuclear androgen receptor binding	IPI IPI: Inferred from physical interaction	17587566	GOA
enables nuclear estrogen receptor binding	IDA IDA: Inferred from direct assay	17587566	GOA
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	12039952	GOA
enables nuclear progesterone receptor binding	IPI IPI: Inferred from physical interaction	12039952	GOA
enables nuclear retinoic acid receptor binding	IPI IPI: Inferred from physical interaction	12039952	GOA
enables nuclear thyroid hormone receptor binding	IPI IPI: Inferred from physical interaction	12039952	GOA
enables peroxisome proliferator activated receptor binding	IPI IPI: Inferred from physical interaction	12039952	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11513728	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12039952	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	12039952	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16648481	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16648481	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12039952	GOA
involved in positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	16648481	GOA
involved in regulation of androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	17587566	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11513728	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17587566	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11513728	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRMT2 Protein Structure

SH3_9

PRMT5

0
100
200
300
400
433 a.a.

Protein Preferred Names

Protein Names

protein arginine N-methyltransferase 2

HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1

PRMT2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRMT2	P55345	SHANK3	Homo sapiens	Q9BYB0	Y2H Pooling	21653829
Intra	PRMT2	P55345	SHANK3	Homo sapiens	Q9BYB0	Anti Tag CoIP	33961781
Intra	PRMT2	P55345	SHANK3	Homo sapiens	Q9BYB0	Anti Tag CoIP	28514442
Intra	PRMT2	P55345	RBM12	Homo sapiens	Q9NTZ6	Validated Y2H	26871637
Intra	PRMT2	P55345	RBM12	Homo sapiens	Q9NTZ6	Y2H Prey Pooling	26871637
Intra	PRMT2	P55345	RBM12	Homo sapiens	Q9NTZ6	Y2H Array	26871637
Intra	PRMT2	P55345	HTT	Homo sapiens	P42858	Anti Tag CoIP	28514442
Intra	PRMT2	P55345	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	PRMT2	P55345	HTT	Homo sapiens	P42858	Anti Tag CoIP	33961781
Intra	PRMT2	P55345	RB1	Homo sapiens	P06400	Anti Bait CoIP	16616919
Intra	PRMT2	P55345	CBLB	Homo sapiens	Q13191	Y2H Prey Pooling	26871637
Intra	PRMT2	P55345	CBLB	Homo sapiens	Q13191	Validated Y2H	26871637
Intra	PRMT2	P55345	CBLB	Homo sapiens	Q13191	Y2H Array	26871637
Intra	PRMT2	P55345	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11170	PRMT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRMT2	MGD	MGI:1316652
Bos taurus	PRMT2	VGNC	VGNC:33348
Felis catus	PRMT2	VGNC	VGNC:67651
Rattus norvegicus	PRMT2	RGD	RGD:1565519
Canis familiaris	PRMT2	VGNC	VGNC:44996
Macaca mulatta	PRMT2	VGNC	VGNC:76359
Others	PRMT2	NCBI

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