DNAJA1 - DnaJ heat shock protein family (Hsp40) member A1 Gene

Homo sapiens

Also known as DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSJ-2; HSPF4; NEDD7; hDJ-2

Gene ID: 3301 | Gene type: protein coding

About DNAJA1

Cytogenetic location: 9p21.1 Genomic coordinates (GRCh38): 9:33,025,273-33,039,907 (from NCBI)

This gene has 3 transcripts (splice variants), 238 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 94.7), brain (RPKM 86.5) and 25 other tissues.

Summary

This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on Other chromosomes. [provided by RefSeq, Sep 2015]

DNAJA1 Products(2)

mRNA	Protein	Name
NM_001314039.2	NP_001300968.1	dnaJ homolog subfamily A member 1 isoform 2
NM_001539.4	NP_001530.1	dnaJ homolog subfamily A member 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase activator activity	IDA IDA: Inferred from direct assay	24318877	GOA
enables C3HC4-type RING finger domain binding	IPI IPI: Inferred from physical interaction	25281747	GOA
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	12150907	GOA
enables Hsp70 protein binding	IDA IDA: Inferred from direct assay	14752510	GOA
enables Tat protein binding	IPI IPI: Inferred from physical interaction	14752510	GOA
enables low-density lipoprotein particle receptor binding	IDA IDA: Inferred from direct assay	15082773	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22085931	GOA
enables protein-folding chaperone binding	IDA IDA: Inferred from direct assay	14752510	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	21231916	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	12150907	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	24512202	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	14752510	GOA
involved in negative regulation of establishment of protein localization to mitochondrion	IDA IDA: Inferred from direct assay	14752510	GOA
involved in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	14752510	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	12150907	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	24512202	GOA
involved in protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	14752510	GOA
involved in regulation of protein transport	IDA IDA: Inferred from direct assay	14752510	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA
located in membrane	IDA IDA: Inferred from direct assay	21231916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJA1 Protein Structure

DnaJ

DnaJ_CXXCXGXG

DnaJ_C

0
100
200
300
397 a.a.

Protein Preferred Names

Protein Names

dnaJ homolog subfamily A member 1

DnaJ (Hsp40) homolog, subfamily A, member 1

DNAJA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DNAJA1	P31689	AICDA	Homo sapiens	Q9GZX7	Anti Tag CoIP	22085931
Intra	DNAJA1	P31689	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	DNAJA1	P31689	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	DNAJA1	P31689	HTT	Homo sapiens	P42858	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Oculopharyngeal Muscular Dystrophy

OPMD	Muscular Dystrophy, Oculopharyngeal
Dystrophy, Oculopharyngeal Muscular	Oculopharyngeal Dystrophy
Progressive Muscular Dystrophy, Oculopharyngeal Type	Muscular Dystrophy Oculopharyngeal
Dystrophy, Muscular, Oculopharyngeal

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116683	116-9e	Inhibitor	98.55%	Unkown
HY-149911	GY1-22	Inhibitor	/	Unkown
HY-RS03857	DNAJA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DNAJA1	VGNC	VGNC:103255
Mus musculus	DNAJA1	MGD	MGI:1270129
Rattus norvegicus	DNAJA1	RGD	RGD:620942
Felis catus	DNAJA1	VGNC	VGNC:102920
Canis familiaris	DNAJA1	VGNC	VGNC:51708
Bos taurus	DNAJA1	VGNC	VGNC:56944

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