HSPA1A - heat shock protein family A (Hsp70) member 1A Gene

Homo sapiens

Also known as HSP70; HSP72; HSPA1; HSP70I; HSP70-1; HSP70-2; HSP70.1; HSP70.2; HSP70-1A; HEL-S-103

Gene ID: 3303 | Gene type: protein coding

About HSPA1A

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,815,543-31,817,942 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 142 orthologues and 13 paralogues.

Summary

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with Other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

HSPA1A Products(1)

mRNA	Protein	Name
NM_005345.6	NP_005336.3	heat shock 70 kDa protein 1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	23921388	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	21231916	GOA
enables ATP-dependent protein disaggregase activity	IDA IDA: Inferred from direct assay	23921388	GOA
enables C3HC4-type RING finger domain binding	IPI IPI: Inferred from physical interaction	25281747	GOA
enables G protein-coupled receptor binding	IDA IDA: Inferred from direct assay	12150907	GOA
enables death receptor agonist activity	IDA IDA: Inferred from direct assay	26183779	GOA
enables denatured protein binding	IPI IPI: Inferred from physical interaction	21909508	GOA
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	11785981	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16809764	GOA
enables misfolded protein binding	IDA IDA: Inferred from direct assay	28842558	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9222587	GOA
enables protein folding chaperone	IDA IDA: Inferred from direct assay	15603737	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	17568691	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	24790089	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	9499401	GOA
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	9499401	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	12150907	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	21231916	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ATP metabolic process	IDA IDA: Inferred from direct assay	23921388	GOA
involved in cellular heat acclimation	IMP IMP: Inferred from mutant phenotype	21231916	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	9499401	GOA
involved in cellular response to unfolded protein	IMP IMP: Inferred from mutant phenotype	20625543	GOA
involved in chaperone-mediated protein complex assembly	IDA IDA: Inferred from direct assay	10811660	GOA
involved in mRNA catabolic process	IDA IDA: Inferred from direct assay	10205060	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17167422	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	9553041	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9553041	GOA
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	12150907	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	17167422	GOA
involved in negative regulation of inclusion body assembly	IDA IDA: Inferred from direct assay	15603737	GOA
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	20625543	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	12150907	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9499401	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24613385	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in positive regulation of RNA splicing	IDA IDA: Inferred from direct assay	20625543	GOA
involved in positive regulation of endoribonuclease activity	IDA IDA: Inferred from direct assay	20625543	GOA
involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17167422	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25281747	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in positive regulation of microtubule nucleation	IMP IMP: Inferred from mutant phenotype	27137183	GOA
involved in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24613385	GOA
involved in positive regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in protein refolding	IDA IDA: Inferred from direct assay	15603737	GOA
involved in protein refolding	IMP IMP: Inferred from mutant phenotype	27708256	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	21909508	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	27137183	GOA
involved in regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16809764	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
located in aggresome	IDA IDA: Inferred from direct assay	15885686	GOA
located in centriole	IDA IDA: Inferred from direct assay	24061851	GOA
located in centrosome	IDA IDA: Inferred from direct assay	27137183	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9553041	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	17568691	GOA
located in inclusion body	IDA IDA: Inferred from direct assay	15603737	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	9553041	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10205060	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10205060	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23349634	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA1A Protein Structure

HSP70

0
100
200
300
400
500
600
641 a.a.

Protein Preferred Names

Protein Names

heat shock 70 kDa protein 1A

HSP70-1/HSP70-2

HSPA1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HSPA1A	P0DMV8	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	HSPA1A	P0DMV8	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	HSPA1A	P0DMV8	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	HSPA1A	P0DMV8	PSMD10	Homo sapiens	O75832	Anti Tag CoIP	24338975
Intra	HSPA1A	P0DMV8	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950
Intra	HSPA1A	P0DMV8	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	HSPA1A	P0DMV8	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	HSPA1A	P0DMV8	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Cross	HSPA1A	P0DMV8	tetX	Clostridium tetani	P04958	Solid Phase Assay	24428437
Cross	HSPA1A	P0DMV8	HA	Influenza A virus	P04663	Solid Phase Assay	24428437

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HSPA1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73105	HSP70/HSPA1B Protein, Human (SF9, His)	P0DMV9/NP_005337.2 (A2-D641)	≥95%
HY-P74877	HSP70/HSPA1A Protein, Human (HEK293, His)	P0DMV8-1/NP_005336.3 (A2-D641)	≥95%
HY-P701004	HSP70/HSPA1A Protein, Human (E110D, His)	P0DMV8-1 (A2-D641, E110D)	≥95%

Related Diseases

Diseases

Alias

Transient Cerebral Ischemia

Transient Ischemic Attack	Transient Ischemic Attacks
Tia	Tia - Transient Ischaemic Attack
Transient Cerebral Ischaemia	Ischemic Attack, Transient
Intermittent Cerebral Ischemia	Tia - [Transient Ischaemic Attack]
Intermittent Cerebral Ischaemia	Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified

Ischemia

Acute Coronary Syndrome

Pulmonary Edema

Pneumoconiosis

Pneumoconioses	Silicosis Nos
Complicated Silicosis	Fibrosis Of Lung With Silicosis
Nodular Silicosis	Pneumoconiosis Due To Silica
Silicotic Fibrosis Of Lung	Simple Silicosis
Silicatosis	Silicotic Lung Fibrosis
Pneumoconiosis Due To Talc	Pulmonary Talcosis
Talc Lung Disease	Talc Pneumoconiosis
Talc Workers' Pneumoconiosis	Talcosis
Fibrosis Of Lung Due To Talc	Asbestos Pneumoconiosis
Amianthosis	Asbestosis
Lung Fibrosis With Asbestosis	Pulmonary Asbestosis

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Acute Kidney Failure

Acute Renal Failure	Acute Kidney Injury
Renal Failure Acute	Kidney Failure, Acute
Pre-Renal Acute Kidney Injury	Nontraumatic Acute Kidney Injury
Aki - [Acute Kidney Injury]	Arf - [Acute Kidney Failure]
Acute Kidney Disease	Acute Kidney Impairment
Acute Ischaemic Renal Failure	Acute Hypoxic Kidney Failure
Acute Kidney Shutdown	Acute Renal Oedema
Acute Renal Impairment	Acute Kidney Collapse
Acute Necrotising Kidney	Acute Renal Suppression

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06424	HSPA1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HSPA1A	RGD	RGD:1593284
Mus musculus	HSPA1A	MGD	MGI:96244

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