HSPA1L - heat shock protein family A (Hsp70) member 1 like Gene

Homo sapiens

Also known as HSP70T; hum70t; HSP70-1L; HSP70-HOM

Gene ID: 3305 | Gene type: protein coding

About HSPA1L

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,809,619-31,815,283 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 110 orthologues and 13 paralogues. Biased expression in testis (RPKM 35.8) and ovary (RPKM 2.3).

Summary

This gene encodes a 70kDa heat shock protein. In conjunction with Other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]

HSPA1L Products(1)

mRNA	Protein	Name
NM_005527.4	NP_005518.3	heat shock 70 kDa protein 1-like

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	17182002	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25036637	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24270810	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	21231916	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	24270810	GOA
involved in protein refolding	IDA IDA: Inferred from direct assay	21231916	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA1L Protein Structure

HSP70

0
100
200
300
400
500
600
641 a.a.

Protein Preferred Names

Protein Names

heat shock 70 kDa protein 1-like

epididymis secretory sperm binding protein

HSPA1L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HSPA1L	P34931	TRIM38	Homo sapiens	O00635	Y2H Prey Pooling	32296183
Intra	HSPA1L	P34931	TRIM38	Homo sapiens	O00635	Y2H Array	32296183
Intra	HSPA1L	P34931	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	HSPA1L	P34931	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Uveoparotid Fever

Heerfordt'S Syndrome

Anthracosis

Black Lung	Coal Workers' Pneumoconiosis
Melanoedema	Black Lung Disease
Pneumoconiosis	Coal Miner'S Pneumoconiosis
Coal Workers' Lung	Coal Worker'S Pneumoconiosis
Coal Workers Pneumoconiosis	Coal Miners' Lung
Coal Miners' Pneumoconiosis	Coal Pneumoconiosis
Colliers' Anthracosis	Colliers' Lung
Lung Melanosis	Miners' Asthma
Miners' Lung	Pneumomelanosis
Cwp - [Coalworkers Pneumoconiosis]	Fibrosis Of Lung With Anthracosilicosis
Lung Fibrosis With Anthracosis	Miners' Pneumoconiosis
Carbon Lung	Coalworker Lung
Collier'S Asthma	Anthracosilicosis
Lung Anthracosis

Visceral Leishmaniasis

Kala-Azar	Leishmaniasis, Visceral
Infection By Visceral Leishmaniasis	Leishmaniasis Visceral
Sahib Disease	Ponos
Burdwan Fever	Mard El Bicha
Sirkari Disease	Indian Visceral Leishmaniasis
Dumdum Fever	Visceral Leishmaniasis Due To Leishmania Donovani

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06426	HSPA1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HSPA1L	RGD	RGD:1595925
Mus musculus	HSPA1L	MGD	MGI:96231
Macaca mulatta	HSPA1L	VGNC	VGNC:81079

Name
Email *

	Sorry, but the email address you supplied was invalid.