TRIM38 - tripartite motif containing 38 Gene

Homo sapiens

Also known as RNF15; RORET

Gene ID: 10475 | Gene type: protein coding

About TRIM38

This gene has 1 transcript (splice variant), 103 orthologues and 80 paralogues. Ubiquitous expression in spleen (RPKM 9.0), lymph node (RPKM 8.4) and 24 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]

TRIM38 Products(1)

mRNA	Protein	Name
NM_006355.5	NP_006346.1	E3 ubiquitin-protein ligase TRIM38

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23275563	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	18248090	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM38 Protein Structure

zf-C3HC4_4

zf-B_box

PRY

SPRY

0
100
200
300
400
465 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM38

RING-type E3 ubiquitin transferase TRIM38

TRIM38 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRIM38	O00635	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
Intra	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	25416956
Intra	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	25416956
Intra	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	TRIM38	O00635	GC20	Homo sapiens	Q6FG85	Validated Y2H	25416956
Intra	TRIM38	O00635	GC20	Homo sapiens	Q6FG85	Y2H Array	25416956
Intra	TRIM38	O00635	GC20	Homo sapiens	Q6FG85	Y2H Prey Pooling	25416956
Intra	TRIM38	O00635	MTURN	Homo sapiens	Q8N3F0	Validated Y2H	32296183
Intra	TRIM38	O00635	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	TRIM38	O00635	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	TRIM38	O00635	RNF4	Homo sapiens	P78317	Validated Y2H	32296183
Intra	TRIM38	O00635	TSPYL4	Homo sapiens	Q9UJ04	Validated Y2H	32296183
Intra	TRIM38	O00635	HSPA8	Homo sapiens	P11142	Validated Y2H	32296183
Intra	TRIM38	O00635	HSPA8	Homo sapiens	P11142	Y2H Array	25416956
Intra	TRIM38	O00635	HSPA1L	Homo sapiens	P34931	Validated Y2H	32296183
Intra	TRIM38	O00635	HSPA2	Homo sapiens	P54652	Validated Y2H	25416956
Intra	TRIM38	O00635	HSPA2	Homo sapiens	P54652	Y2H Array	31515488
Intra	TRIM38	O00635	HSPA2	Homo sapiens	P54652	Y2H Prey Pooling	25416956
Intra	TRIM38	O00635	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
Intra	TRIM38	O00635	PSMA4	Homo sapiens	P25789	Y2H Array	32296183
Intra	TRIM38	O00635	PSMA4	Homo sapiens	P25789	Validated Y2H	32296183
Intra	TRIM38	O00635	PIAS4	Homo sapiens	Q8N2W9	Y2H Prey Pooling	32296183
Intra	TRIM38	O00635	PIAS4	Homo sapiens	Q8N2W9	Validated Y2H	32296183
Intra	TRIM38	O00635	PIAS4	Homo sapiens	Q8N2W9	Y2H Array	32296183
Intra	TRIM38	O00635	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
Intra	TRIM38	O00635	RFC5	Homo sapiens	P40937	Validated Y2H	25416956
Intra	TRIM38	O00635	RFC5	Homo sapiens	P40937	Validated Y2H	32296183
Intra	TRIM38	O00635	RFC5	Homo sapiens	P40937	Y2H Array	25416956
Intra	TRIM38	O00635	RFC5	Homo sapiens	P40937	Y2H Prey Pooling	25416956
Intra	TRIM38	O00635	RFC5	Homo sapiens	P40937	Y2H Array	29892012
Intra	TRIM38	O00635	RFC5	Homo sapiens	P40937	Y2H Array	31515488
Intra	TRIM38	O00635	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	TRIM38	O00635	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	TRIM38	O00635	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	25416956
Intra	TRIM38	O00635	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	TRIM38	O00635	ZNF764	Homo sapiens	Q96H86	Validated Y2H	32296183
Intra	TRIM38	O00635	ATXN1	Homo sapiens	P54253	Y2H Prey Pooling	23275563
Intra	TRIM38	O00635	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	TRIM38	O00635	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	TRIM38	O00635	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	TRIM38	O00635	STXBP1	Homo sapiens	P61764	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fanconi Renotubular Syndrome 2

FRTS2

Fanconi Renotubular Syndrome, Type 2

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15042	TRIM38 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRIM38	VGNC	VGNC:78548
Bos taurus	TRIM38	VGNC	VGNC:36333
Rattus norvegicus	TRIM38	RGD	RGD:1596868
Canis familiaris	TRIM38	VGNC	VGNC:47819
Felis catus	TRIM38	VGNC	VGNC:66537
Mus musculus	TRIM38	MGD	MGI:2684869

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