BAG4 - BAG cochaperone 4 Gene

Homo sapiens

Also known as SODD; BAG-4

Gene ID: 9530 | Gene type: protein coding

About BAG4

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:38,176,855-38,213,301 (from NCBI)

This gene has 4 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 11.2), bone marrow (RPKM 7.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell Apoptosis and growth related proteins including Bcl-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/HSP70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo Apoptosis while Integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

BAG4 Products(2)

mRNA	Protein	Name
NM_001204878.2	NP_001191807.1	BAG family molecular chaperone regulator 4 isoform 2
NM_004874.4	NP_004865.1	BAG family molecular chaperone regulator 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25036637	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24270810	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	21712384	GOA
involved in negative regulation of protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	24270810	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21712384	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21712384	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21712384	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAG4 Protein Structure

BAG

0
100
200
300
400
457 a.a.

Protein Preferred Names

Protein Names

BAG family molecular chaperone regulator 4

BCL2 associated athanogene 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01345	BAG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BAG4	VGNC	VGNC:26408
Canis familiaris	BAG4	VGNC	VGNC:38366
Macaca mulatta	BAG4	VGNC	VGNC:70220
Mus musculus	BAG4	MGD	MGI:1914634
Felis catus	BAG4	VGNC	VGNC:78455
Rattus norvegicus	BAG4	RGD	RGD:1560875
Others	BAG4	NCBI

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