BAG4 - BAG cochaperone 4 Gene

Homo sapiens

Also known as SODD; BAG-4

Gene ID: 9530 | Gene type: protein coding

About BAG4

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:38,176,855-38,213,301 (from NCBI)

This gene has 4 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 11.2), bone marrow (RPKM 7.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell Apoptosis and growth related proteins including Bcl-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/HSP70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo Apoptosis while Integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

BAG4 Products(2)

mRNA	Protein	Name
NM_001204878.2	NP_001191807.1	BAG family molecular chaperone regulator 4 isoform 2
NM_004874.4	NP_004865.1	BAG family molecular chaperone regulator 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25036637	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24270810	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	21712384	GOA
involved in negative regulation of protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	24270810	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21712384	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21712384	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21712384	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAG4 Protein Structure

BAG

0
100
200
300
400
457 a.a.

Protein Preferred Names

Protein Names

BAG family molecular chaperone regulator 4

BCL2 associated athanogene 4

BAG4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BAG4	O95429	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	32296183
Intra	BAG4	O95429	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32296183
Intra	BAG4	O95429	BCL6B	Homo sapiens	A8KA13	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	BCL6B	Homo sapiens	A8KA13	Y2H Array	32296183
Intra	BAG4	O95429	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	BAG4	O95429	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	BAG4	O95429	P4HA3	Homo sapiens	Q7Z4N8	Validated Y2H	32296183
Intra	BAG4	O95429	ALG13	Homo sapiens	Q9NP73-4	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	ALG13	Homo sapiens	Q9NP73-4	Validated Y2H	32296183
Intra	BAG4	O95429	ALG13	Homo sapiens	Q9NP73-4	Y2H Array	32296183
Intra	BAG4	O95429	ODF1	Homo sapiens	Q14990	Validated Y2H	32296183
Intra	BAG4	O95429	ODF1	Homo sapiens	Q14990	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	ODF1	Homo sapiens	Q14990	Y2H Array	32296183
Intra	BAG4	O95429	TEKT5	Homo sapiens	Q96M29	Validated Y2H	32296183
Intra	BAG4	O95429	ERVK3-1	Homo sapiens	Q96A10	Validated Y2H	32296183
Intra	BAG4	O95429	FYN	Homo sapiens	P06241-3	Validated Y2H	32296183
Intra	BAG4	O95429	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	BAG4	O95429	SIAH1	Homo sapiens	Q8IUQ4-2	Validated Y2H	32296183
Intra	BAG4	O95429	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	BAG4	O95429	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	BAG4	O95429	TFAP2D	Homo sapiens	Q7Z6R9	Validated Y2H	32296183
Intra	BAG4	O95429	KRTAP13-4	Homo sapiens	Q3LI77	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	KRTAP13-4	Homo sapiens	Q3LI77	Validated Y2H	32296183
Intra	BAG4	O95429	KRTAP13-4	Homo sapiens	Q3LI77	Y2H Array	32296183
Intra	BAG4	O95429	KCTD7	Homo sapiens	Q96MP8-2	Validated Y2H	32296183
Intra	BAG4	O95429	KRTAP4-4	Homo sapiens	Q9BYR3	Validated Y2H	32296183
Intra	BAG4	O95429	ZIM2	Homo sapiens	Q9NZV7	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	ZIM2	Homo sapiens	Q9NZV7	Validated Y2H	32296183
Intra	BAG4	O95429	ZIM2	Homo sapiens	Q9NZV7	Y2H Array	32296183
Intra	BAG4	O95429	SAMD4A	Homo sapiens	Q9UPU9-3	Validated Y2H	32296183
Intra	BAG4	O95429	KRTAP4-5	Homo sapiens	Q9BYR2	Validated Y2H	32296183
Intra	BAG4	O95429	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	BAG4	O95429	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Array	32296183
Intra	BAG4	O95429	RUNX1	Homo sapiens	Q01196-8	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	RUNX1	Homo sapiens	Q01196-8	Y2H Array	32296183
Intra	BAG4	O95429	RUNX1	Homo sapiens	Q01196-8	Validated Y2H	32296183
Intra	BAG4	O95429	C3orf38	Homo sapiens	Q5JPI3-2	Anti Tag CoIP	28514442
Intra	BAG4	O95429	C3orf38	Homo sapiens	Q5JPI3-2	Validated Y2H	32296183
Intra	BAG4	O95429	USP22	Homo sapiens	Q9UPT9-2	Validated Y2H	32296183
Intra	BAG4	O95429	IST1	Homo sapiens	P53990-3	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	IST1	Homo sapiens	P53990-3	Validated Y2H	32296183
Intra	BAG4	O95429	IST1	Homo sapiens	P53990-3	Y2H Array	32296183
Intra	BAG4	O95429	PPIL6	Homo sapiens	Q8IXY8	Validated Y2H	32296183
Intra	BAG4	O95429	ATP23	Homo sapiens	Q9Y6H3	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	ATP23	Homo sapiens	Q9Y6H3	Validated Y2H	32296183
Intra	BAG4	O95429	ATP23	Homo sapiens	Q9Y6H3	Y2H Array	32296183
Intra	BAG4	O95429	UNKL	Homo sapiens	Q9H9P5-5	Validated Y2H	32296183
Intra	BAG4	O95429	UNKL	Homo sapiens	Q9H9P5-5	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	UNKL	Homo sapiens	Q9H9P5-5	Y2H Array	32296183
Intra	BAG4	O95429	TBC1D3G	Homo sapiens	Q6DHY5	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	TBC1D3G	Homo sapiens	Q6DHY5	Validated Y2H	32296183
Intra	BAG4	O95429	TBC1D3G	Homo sapiens	Q6DHY5	Y2H Array	32296183
Intra	BAG4	O95429	CIMAP1C	Homo sapiens	Q8IXM7	Validated Y2H	32296183
Intra	BAG4	O95429	CIMAP1C	Homo sapiens	Q8IXM7	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	CIMAP1C	Homo sapiens	Q8IXM7	Y2H Array	32296183
Intra	BAG4	O95429	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
Intra	BAG4	O95429	SH3RF2	Homo sapiens	Q8TEC5	Validated Y2H	32296183
Intra	BAG4	O95429	PHF19	Homo sapiens	Q5T6S3	Validated Y2H	32296183
Intra	BAG4	O95429	KCTD6	Homo sapiens	Q8NC69	Validated Y2H	32296183
Intra	BAG4	O95429	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	BAG4	O95429	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	BAG4	O95429	FAM222B	Homo sapiens	Q8WU58	Validated Y2H	32296183
Intra	BAG4	O95429	MYPOP	Homo sapiens	Q86VE0	Validated Y2H	32296183
Intra	BAG4	O95429	PYCR3	Homo sapiens	Q53H96	Validated Y2H	32296183
Intra	BAG4	O95429	TBC1D7	Homo sapiens	Q9P0N9	Validated Y2H	32296183
Intra	BAG4	O95429	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	BAG4	O95429	HSPA8	Homo sapiens	P11142	Validated Y2H	32296183
Intra	BAG4	O95429	HSPA1L	Homo sapiens	P34931	Validated Y2H	32296183
Intra	BAG4	O95429	HSPA1L	Homo sapiens	P34931	Anti Tag CoIP	25036637
Intra	BAG4	O95429	HSPA6	Homo sapiens	P17066	Validated Y2H	32296183
Intra	BAG4	O95429	KIF5B	Homo sapiens	P33176	Validated Y2H	32296183
Intra	BAG4	O95429	HSPA2	Homo sapiens	P54652	Validated Y2H	32296183
Intra	BAG4	O95429	HSPA2	Homo sapiens	P54652	Lumier	25036637
Intra	BAG4	O95429	HSPA2	Homo sapiens	P54652	Anti Tag CoIP	25036637
Intra	BAG4	O95429	DNAJC7	Homo sapiens	Q99615	Lumier	25036637
Intra	BAG4	O95429	DNAJC7	Homo sapiens	Q99615	Anti Tag CoIP	25036637
Intra	BAG4	O95429	PSMB5	Homo sapiens	P28074	Validated Y2H	32296183
Intra	BAG4	O95429	SNRPB	Homo sapiens	P14678-2	Validated Y2H	32296183
Intra	BAG4	O95429	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	25036637
Intra	BAG4	O95429	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	28514442
Intra	BAG4	O95429	DCP1A	Homo sapiens	Q9NPI6	Lumier	25036637
Intra	BAG4	O95429	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	33961781
Intra	BAG4	O95429	SUOX	Homo sapiens	P51687	Validated Y2H	32296183
Intra	BAG4	O95429	SAXO1	Homo sapiens	Q8IYX7	Validated Y2H	32296183
Intra	BAG4	O95429	CASP2	Homo sapiens	P42575	Validated Y2H	32296183
Intra	BAG4	O95429	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	33961781
Intra	BAG4	O95429	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	28514442
Intra	BAG4	O95429	EFEMP1	Homo sapiens	Q12805	Validated Y2H	32296183
Intra	BAG4	O95429	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	BAG4	O95429	FTH1	Homo sapiens	P02794	Complementation	32296183
Intra	BAG4	O95429	FTH1	Homo sapiens	P02794	Validated Y2H	32296183
Intra	BAG4	O95429	GPS2	Homo sapiens	Q13227	Validated Y2H	32296183
Intra	BAG4	O95429	ZBTB45	Homo sapiens	Q96K62	Validated Y2H	32296183
Intra	BAG4	O95429	TINAGL1	Homo sapiens	Q9GZM7	Y2H Array	32296183
Intra	BAG4	O95429	TINAGL1	Homo sapiens	Q9GZM7	Validated Y2H	32296183
Intra	BAG4	O95429	TINAGL1	Homo sapiens	Q9GZM7	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	BAG4	O95429	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	32296183
Intra	BAG4	O95429	TCL1B	Homo sapiens	O95988	Validated Y2H	32296183
Intra	BAG4	O95429	KRTAP4-12	Homo sapiens	Q9BQ66	Validated Y2H	32296183
Intra	BAG4	O95429	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	BAG4	O95429	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	BAG4	O95429	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	BAG4	O95429	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	BAG4	O95429	RAMAC	Homo sapiens	Q9BTL3	Validated Y2H	32296183
Intra	BAG4	O95429	RAMAC	Homo sapiens	Q9BTL3	Complementation	32296183
Intra	BAG4	O95429	MYOZ1	Homo sapiens	Q9NP98	Validated Y2H	32296183
Intra	BAG4	O95429	ATOSB	Homo sapiens	Q7L5A3	Validated Y2H	32296183
Intra	BAG4	O95429	q96ej4_human	Homo sapiens	Q96EJ4	Validated Y2H	32296183
Intra	BAG4	O95429	GPANK1	Homo sapiens	O95872	Validated Y2H	32296183
Intra	BAG4	O95429	SNRPC	Homo sapiens	P09234	Validated Y2H	32296183
Intra	BAG4	O95429	LASP1	Homo sapiens	Q14847-2	Validated Y2H	32296183
Intra	BAG4	O95429	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	BAG4	O95429	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	ARID5A	Homo sapiens	Q03989	Validated Y2H	32296183
Intra	BAG4	O95429	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	BAG4	O95429	DZIP3	Homo sapiens	Q86Y13	Y2H Prey Pooling	32296183
Intra	BAG4	O95429	DZIP3	Homo sapiens	Q86Y13	Validated Y2H	32296183
Intra	BAG4	O95429	DZIP3	Homo sapiens	Q86Y13	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

BAG4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82213	SODD Antibody (YA1958)	WB, IHC-F, IHC-P, ICC/IF	Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01345	BAG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BAG4	VGNC	VGNC:26408
Canis familiaris	BAG4	VGNC	VGNC:38366
Macaca mulatta	BAG4	VGNC	VGNC:70220
Mus musculus	BAG4	MGD	MGI:1914634
Felis catus	BAG4	VGNC	VGNC:78455
Rattus norvegicus	BAG4	RGD	RGD:1560875
Others	BAG4	NCBI

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