APLP2 - amyloid beta precursor like protein 2 Gene

Homo sapiens

Also known as APPH; APPL2; CDEBP; APLP-2

Gene ID: 334 | Gene type: protein coding

About APLP2

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:130,069,894-130,144,805 (from NCBI)

This gene has 26 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 347.8), lung (RPKM 236.7) and 24 other tissues.

Summary

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

APLP2 Products(30)

mRNA	Protein	Name
NM_001142276.2	NP_001135748.1	amyloid beta precursor like protein 2 isoform 2 precursor
NM_001142277.2	NP_001135749.1	amyloid beta precursor like protein 2 isoform 3
NM_001142278.2	NP_001135750.1	amyloid beta precursor like protein 2 isoform 4 precursor
NM_001243299.2	NP_001230228.1	amyloid beta precursor like protein 2 isoform 5
NM_001328682.2	NP_001315611.1	amyloid beta precursor like protein 2 isoform 6 precursor
NM_001328684.2	NP_001315613.1	amyloid beta precursor like protein 2 isoform 7 precursor
NM_001328685.2	NP_001315614.1	amyloid beta precursor like protein 2 isoform 8 precursor
NM_001328686.2	NP_001315615.1	amyloid beta precursor like protein 2 isoform 9 precursor
NM_001382526.1	NP_001369455.1	amyloid beta precursor like protein 2 isoform 10 precursor
NM_001382527.1	NP_001369456.1	amyloid beta precursor like protein 2 isoform 11 precursor
NM_001382528.1	NP_001369457.1	amyloid beta precursor like protein 2 isoform 12
NM_001382529.1	NP_001369458.1	amyloid beta precursor like protein 2 isoform 13 precursor
NM_001382530.1	NP_001369459.1	amyloid beta precursor like protein 2 isoform 14
NM_001382531.1	NP_001369460.1	amyloid beta precursor like protein 2 isoform 15
NM_001382532.1	NP_001369461.1	amyloid beta precursor like protein 2 isoform 16
NM_001382533.1	NP_001369462.1	amyloid beta precursor like protein 2 isoform 17
NM_001382534.1	NP_001369463.1	amyloid beta precursor like protein 2 isoform 18
NM_001382535.1	NP_001369464.1	amyloid beta precursor like protein 2 isoform 19
NM_001382536.1	NP_001369465.1	amyloid beta precursor like protein 2 isoform 20
NM_001382537.1	NP_001369466.1	amyloid beta precursor like protein 2 isoform 21
NM_001382538.1	NP_001369467.1	amyloid beta precursor like protein 2 isoform 22 precursor
NM_001382539.1	NP_001369468.1	amyloid beta precursor like protein 2 isoform 23
NM_001382540.1	NP_001369469.1	amyloid beta precursor like protein 2 isoform 24
NM_001382541.1	NP_001369470.1	amyloid beta precursor like protein 2 isoform 25
NM_001382542.1	NP_001369471.1	amyloid beta precursor like protein 2 isoform 26
NM_001382543.1	NP_001369472.1	amyloid beta precursor like protein 2 isoform 27
NM_001382544.1	NP_001369473.1	amyloid beta precursor like protein 2 isoform 28
NM_001382545.1	NP_001369474.1	amyloid beta precursor like protein 2 isoform 29
NM_001382546.1	NP_001369475.1	amyloid beta precursor like protein 2 isoform 30 precursor
NM_001642.3	NP_001633.1	amyloid beta precursor like protein 2 isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16193067	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8855266	GOA
enables serine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	25301953	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	7702756	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APLP2 Protein Structure

APP_N

APP_Cu_bd

Kunitz_BPTI

APP_E2

APP_amyloid

0
200
400
600
763 a.a.

Protein Preferred Names

Protein Names

amyloid beta precursor like protein 2

CDEI box-binding protein

APLP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	APLP2	Q06481	DEDD	Homo sapiens	O75618	Display Tech	20195357
Intra	APLP2	Q06481	DEDD	Homo sapiens	O75618	TAP	20195357
Intra	APLP2	Q06481	APBB3	Homo sapiens	O95704	Y2H	9461550
Intra	APLP2	Q06481	ITM2B	Homo sapiens	Q9Y287	Anti Bait CoIP	34446781
Intra	APLP2	Q06481	APP	Homo sapiens	P05067-4	Anti Tag CoIP	16193067
Intra	APLP2	Q06481	MED12	Homo sapiens	Q93074	Pull Down	21293490
Intra	APLP2	Q06481	APLP1	Homo sapiens	P51693	Anti Tag CoIP	16193067
Intra	APLP2	Q06481	APBB2	Homo sapiens	Q92870	Anti Bait CoIP	8855266
Intra	APLP2	Q06481	JUN	Homo sapiens	P05412	Display Tech	20195357
Intra	APLP2	Q06481	APLP2	Homo sapiens	Q06481	Anti Tag CoIP	16193067
Intra	APLP2	Q06481	APBB1	Homo sapiens	O00213	Y2H	9461550
Intra	APLP2	Q06481	APLP2	Homo sapiens	Q06481	Anti Bait CoIP	16193067
Intra	APLP2	Q06481	ETS1	Homo sapiens	P14921	Display Tech	20195357

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant APLP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700659	APLP-2 Protein, Human (HEK293, His)	Q06481-1 (G32-S692)	≥95%

Related Diseases

Diseases

Alias

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00827	APLP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	APLP2	VGNC	VGNC:37989
Felis catus	APLP2	VGNC	VGNC:67762
Rattus norvegicus	APLP2	RGD	RGD:2128
Mus musculus	APLP2	MGD	MGI:88047
Bos taurus	APLP2	VGNC	VGNC:26020
Macaca mulatta	APLP2	VGNC	VGNC:69984

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